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Product Details
PA5-86697
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 530-575 of Human Thrombomodulin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803457
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Thrombomodulin (TM) is also known as Fetomodulin (FM), endothelial anticoagulant protein, or glycoprotein P112. Thrombomodulin contains six repeated domains homologous with epidermal growth factor (EGF) and an amino terminal domain homologous to lectin-like protein. Through its accelerated activation of protein C, synthesis of TM is one of several mechanisms important in maintaining thrombo-resistance and thus reducing clot formation on the surface of the endothelial cells. Immunohistochemical staining of formalin-fixed tissue for TM has been used for the study of a variety of vascular tumors, meningiomas and choriocarcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BDCA-3; CD141; CD141 antigen; DC141; Fetomodulin; sCD141; snoRNA MBII-339; soluble CD141; thrombomdulin; Thrombomodulin; TM
Gene Aliases: AHUS6; AI385582; BDCA3; CD141; THBD; THPH12; THRM; TM
UniProt ID: (Human) P07204, (Mouse) P15306
Entrez Gene ID: (Human) 7056, (Mouse) 21824, (Rat) 83580
signal transduction
female pregnancy
blood coagulation
response to X-ray
negative regulation of platelet activation
negative regulation of blood coagulation
response to lipopolysaccharide
leukocyte migration
response to cAMP
negative regulation of fibrinolysis
hemostasis
embryo development
negative regulation of coagulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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