Product References
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Cell death & disease
Zheng H,Guo X,Kang S,Li Z,Tian T,Li J,Wang F,Yu P,Chang S,Chang YZ
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to reveal a dual consequence of FPN1 deficiency in ECs in the development of ischemic stroke.
Sat Feb 25 00:00:00 EST 2023
Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Nature communications
Calcagni' A,Staiano L,Zampelli N,Minopoli N,Herz NJ,Di Tullio G,Huynh T,Monfregola J,Esposito A,Cirillo C,Bajic A,Zahabiyon M,Curnock R,Polishchuk E,Parkitny L,Medina DL,Pastore N,Cullen PJ,Parenti G,De Matteis MA,Grumati P,Ballabio A
13-6890 was used in Western Blotting to reveal that CLN3 functions as a link between the M6P-dependent trafficking of lysosomal enzymes and lysosomal reformation pathway, explaining the global impairment of lysosomal function in Batten disease.
Mon Jul 03 00:00:00 EDT 2023
Application of In vitro transcytosis models to brain targeted biologics.
PloS one
Deng K,Lu Y,Finnema SJ,Vangjeli K,Huang J,Huang L,Goodearl A
13-6890 was used in Simple Western - Size to evaluate human models including human cerebral microvascular endothelial cell line hCMEC/D3 and human colon epithelial cell line Caco-2 models.
Fri Aug 25 00:00:00 EDT 2023
Application of In vitro transcytosis models to brain targeted biologics.
PloS one
Deng K,Lu Y,Finnema SJ,Vangjeli K,Huang J,Huang L,Goodearl A
13-6890 was used in Simple Western - Size to evaluate human models including human cerebral microvascular endothelial cell line hCMEC/D3 and human colon epithelial cell line Caco-2 models.
Fri Aug 25 00:00:00 EDT 2023
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.
Life science alliance
Badenes M,Burbridge E,Oikonomidi I,Amin A,de Carvalho É,Kosack L,Mariano C,Domingos P,Faísca P,Adrain C
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to suggest that pharmacological intervention at the level of iTAP/Frmd8 may be beneficial to target ADAM17 activity in specific compartments during chronic inflammatory diseases or cancer, while avoiding the collateral impact on the vital functions associated with the widespread inhibition of ADAM17.
Sat Apr 01 00:00:00 EDT 2023
Usefulness of a humanized tricellular static transwell blood-brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system.
Regenerative therapy
Nakayama-Kitamura K,Shigemoto-Mogami Y,Toyoda H,Mihara I,Moriguchi H,Naraoka H,Furihata T,Ishida S,Sato K
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to provide the SOPs with the flow chart including entire procedure and how to apply each SOP.
Wed Mar 01 00:00:00 EST 2023
Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia.
International journal of nanomedicine
Yang XY,Geng L,Li R,Song JX,Jia CL,An JR,Sun MF,Xu S,Guo YJ,Zhao Y,Ji ES
13-6800 was used in Western Blotting to investigate the neuroprotective effect of Huperzine A (HuA) packaged with nanoliposomes (HuA-LIP) on neuronal damage induced by CIH.
Mon Feb 27 00:00:00 EST 2023
Mouse embryonic stem cell-derived blood-brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis.
Fluids and barriers of the CNS
Jezierski A,Huang J,Haqqani AS,Haukenfrers J,Liu Z,Baumann E,Sodja C,Charlebois C,Delaney CE,Star AT,Liu Q,Stanimirovic DB
13-6800 was used in Western Blotting to compare transport of a panel of antibodies binding species selective or cross-reactive epitopes on BBB RMT receptors in both the mBEC and human iPSC-derived BEC model, to demonstrate discrimination of species-specific BBB transport mechanisms.
Fri May 26 00:00:00 EDT 2023
CHIR99021 Maintenance of the Cell Stemness by Regulating Cellular Iron Metabolism.
Antioxidants (Basel, Switzerland)
Han Y,He Y,Jin X,Xie J,Yu P,Gao G,Chang S,Zhang J,Chang YZ
13-6890 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to reveal novel mechanisms of the maintenance of cell stemness and differentiation and provide a theoretical basis for the development of new strategies in stem cell treatment in disease.
Sat Feb 04 00:00:00 EST 2023
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Nature neuroscience
van Lengerich B,Zhan L,Xia D,Chan D,Joy D,Park JI,Tatarakis D,Calvert M,Hummel S,Lianoglou S,Pizzo ME,Prorok R,Thomsen E,Bartos LM,Beumers P,Capell A,Davis SS,de Weerd L,Dugas JC,Duque J,Earr T,Gadkar K,Giese T,Gill A,Gnörich J,Ha C,Kannuswamy M,Kim DJ,Kunte ST,Kunze LH,Lac D,Lechtenberg K,Leung AW,Liang CC,Lopez I,McQuade P,Modi A,Torres VO,Nguyen HN,Pesämaa I,Propson N,Reich M,Robles-Colmenares Y,Schlepckow K,Slemann L,Solanoy H,Suh JH,Thorne RG,Vieira C,Wind-Mark K,Xiong K,Zuchero YJY,Diaz D,Dennis MS,Huang F,Scearce-Levie K,Watts RJ,Haass C,Lewcock JW,Di Paolo G,Brendel M,Sanchez PE,Monroe KM
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to show that in an AD mouse model, ATV:TREM2 boosted brain microglial activity and glucose metabolism and that ATV:TREM2 represents a promising approach to improve microglial function and treat brain hypometabolism found in patients with AD.
Wed Mar 01 00:00:00 EST 2023
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep.
The EMBO journal
Pinto MJ,Cottin L,Dingli F,Laigle V,Ribeiro LF,Triller A,Henderson F,Loew D,Fabre V,Bessis A
13-6800 was used in Western Blotting to suggest that microglia control sleep homeostasis by releasing TNFα which acts on neuronal circuitry through dynamic control of phosphorylation.
Wed Jan 04 00:00:00 EST 2023
Effect of Hypoxia-Ischemia on the Expression of Iron-Related Proteins in Neonatal Rat Brains.
Neural plasticity
Lin Q,Hu DW,Hao XH,Zhang G,Lin L
13-6800 was used in Western Blotting to investigate the iron-related protein changes in neonatal rats after hypoxia-ischemia (HI), clarify the role of iron-related proteins in hypoxic-ischemic WMI, and potentially provide a new target for the clinical treatment of hypoxic-ischemic WMI in preterm infants.
Sat May 06 00:00:00 EDT 2023
The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.
Molecular neurobiology
Brandimarti R,Irollo E,Meucci O
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to introduce a new method to limit APP misprocessing and its cellular consequences without directly targeting secretase activity, offering a novel tool to reduce cognitive decline in pathologies such as Alzheimer's disease and HIV-associated neurocognitive disorders.
Sat Apr 01 00:00:00 EDT 2023
A druggable copper-signalling pathway that drives inflammation.
Nature
Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R
13-6800 was used in Western Blotting to highlight the central role of copper as a regulator of cell plasticity and unveils a therapeutic strategy based on metabolic reprogramming and the control of epigenetic cell states.
Mon May 01 00:00:00 EDT 2023
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson's disease.
Neural regeneration research
Hu CB,Jiang H,Yang Y,Wang GH,Ji QH,Jia ZZ,Shen LH,Luo QQ
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to establish a rat model of Parkinson's disease by intraperitoneal injection of rotenone for 28 successive days, followed by intragastric injection of NBP for 14-28 days and suggest that NBP alleviates motor disturbance by inhibition of iron deposition, oxidative stress, and ferroptosis in the substantia nigra.
Sun Jan 01 00:00:00 EST 2023
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.
eLife
Wu S,Hernandez Villegas NC,Sirkis DW,Thomas-Wright I,Wade-Martins R,Schekman R
13-6800 was used in Western Blot to propose that DNAJC5 forms a palmitoylated oligomer to accommodate and export α-syn.
Tue Jan 10 00:00:00 EST 2023
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Frontiers in cellular neuroscience
An JR,Liu JT,Gao XM,Wang QF,Sun GY,Su JN,Zhang C,Yu JX,Yang YF,Shi Y
13-6890 was used in Western Blot to explore the effect of liraglutide on the activation of different astrocyte phenotypes and neuroinflammation in the hippocampus of a T2DM model and further revealed its intervention effect on cognitive impairment in diabetes.
Mon Jun 19 00:00:00 EDT 2023
Endocytosis in the axon initial segment maintains neuronal polarity.
Nature
Eichel K,Uenaka T,Belapurkar V,Lu R,Cheng S,Pak JS,Taylor CA,Südhof TC,Malenka R,Wernig M,Özkan E,Perrais D,Shen K
13-6800 was used in Flow cytometry/Cell sorting to reveal a conserved endocytic clearance mechanism in the AIS to maintain neuronal polarity by reinforcing axonal and dendritic compartment membrane boundaries.
Thu Sep 01 00:00:00 EDT 2022
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond.
Proceedings of the National Academy of Sciences of the United States of America
Chen S,Li W,Zheng X,Yu P,Wang P,Sun Z,Xu Y,Jiao D,Ye X,Cai M,Shen M,Wang M,Zhang Q,Kong F,Wang Y,He J,Wei H,Shi F,Du J
13-6800 was used in Immunocytochemistry, Immunohistochemistry to provide a different histological method for both molecular mechanism research and accurate diagnosis of human cancer.
Tue Feb 01 00:00:00 EST 2022
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond.
Proceedings of the National Academy of Sciences of the United States of America
Chen S,Li W,Zheng X,Yu P,Wang P,Sun Z,Xu Y,Jiao D,Ye X,Cai M,Shen M,Wang M,Zhang Q,Kong F,Wang Y,He J,Wei H,Shi F,Du J
13-6800 was used in Immunocytochemistry, Immunohistochemistry to provide a different histological method for both molecular mechanism research and accurate diagnosis of human cancer.
Tue Feb 01 00:00:00 EST 2022
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Oncogene
Cicek E,Circir A,Oyken M,Akbulut Caliskan O,Dioken DN,Guntekin Ergun S,Cetin-Atalay R,Sapmaz A,Ovaa H,Sahin O,Erson-Bensan AE
13-6890 was used in Immunocytochemistry-immunoflourescence to suggest that SNX3 is a critical player in the EGFR network in TNBCs with implications for other cancers dependent on EGFR activity.
Sat Jan 01 00:00:00 EST 2022
Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons.
Frontiers in cell and developmental biology
Prael Iii FJ,Kim K,Du Y,Spitznagel BD,Sulikowski GA,Delpire E,Weaver CD
13-6800 was used in Western Blotting to evaluate the therapeutic potential of pharmacological KCC2 potentiation.
Sat Feb 11 00:00:00 EST 2023
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
Journal of cell science
Søreng K,Pankiv S,Bergsmark C,Haugsten EM,Dahl AK,de la Ballina LR,Yamamoto A,Lystad AH,Simonsen A
13-6890 was used in Immunocytochemistry to show that ALFY localizes to RAB5- and EEA1-positive early endosomes in a PtdIns(3)P-dependent manner and is highly enriched in cellular protrusions at the leading and lagging edge of migrating cells.
Tue Feb 15 00:00:00 EST 2022
Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167.
International journal of molecular sciences
Ghilarducci K,Cabana VC,Harake A,Cappadocia L,Lussier MP
13-6800 was used in Western Blotting to report that RNF167, a transmembrane endolysosomal ubiquitin ligase, can ubiquitinate Rab7.
Sat Jul 16 00:00:00 EDT 2022
Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin.
Journal of cell science
Higashi S,Makiyama T,Sakane H,Nogami S,Shirataki H
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to suggest that γ-taxilin negatively regulates the sorting of Hook1-mediated cargo proteins into recycling endosomes by interfering with the interactions between Hook1 and the cargo proteins.
Thu Dec 01 00:00:00 EST 2022
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.
Cell chemical biology
Armenta DA,Laqtom NN,Alchemy G,Dong W,Morrow D,Poltorack CD,Nathanson DA,Abu-Remalieh M,Dixon SJ
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to identify the catabolism of extracellular protein within the lysosome as a mechanism that can inhibit ferroptosis in cancer cells.
Thu Nov 17 00:00:00 EST 2022
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
iScience
Tejeda-Muñoz N,Morselli M,Moriyama Y,Sheladiya P,Pellegrini M,De Robertis EM
13-6800 was used in GST Pull Down to understand how Wnt signalling causes endocytotic mechanisms involving the reduction of focal adhesion proteins and integrin beta 1 from the cell surface.
Fri Apr 15 00:00:00 EDT 2022
Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.
Journal of cell science
Parveen S,Khamari A,Raju J,Coppolino MG,Datta S
13-6800 was used in Immunocytochemistry-immunofluorescence to highlight STX7 as a major contributor towards the invadopodia formation during cancer cell invasion.
Wed Jun 15 00:00:00 EDT 2022
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice.
Cell death & disease
Li ZD,Li H,Kang S,Cui YG,Zheng H,Wang P,Han K,Yu P,Chang YZ
13-6800 was used in Western Blotting to demonstrate that astrocytic Cp deletion has divergent effects on learning and memory function via different regulatory mechanisms induced by decreased iron contents in the brain of mice, which may present strategies for the prevention and treatment of dementia.
Mon Nov 28 00:00:00 EST 2022
Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton.
eLife
Das BK,Wang L,Fujiwara T,Zhou J,Aykin-Burns N,Krager KJ,Lan R,Mackintosh SG,Edmondson R,Jennings ML,Wang X,Feng JQ,Barrientos T,Gogoi J,Kannan A,Gao L,Xing W,Mohan S,Zhao H
13-6800 was used in Western Blotting to indicate that Tfr1-mediated iron uptake is specifically required for osteoclast function and is indispensable for bone remodeling in a gender-dependent manner.
Mon Jun 27 00:00:00 EDT 2022
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Nature communications
Spix B,Butz ES,Chen CC,Rosato AS,Tang R,Jeridi A,Kudrina V,Plesch E,Wartenberg P,Arlt E,Briukhovetska D,Ansari M,Günsel GG,Conlon TM,Wyatt A,Wetzel S,Teupser D,Holdt LM,Ectors F,Boekhoff I,Boehm U,García-Añoveros J,Saftig P,Giera M,Kobold S,Schiller HB,Zierler S,Gudermann T,Wahl-Schott C,Bracher F,Yildirim AÖ,Biel M,Grimm C
13-6800 was used in Western Blot to suggest that TRPML3 represents a key regulator of MMP-12 clearance by alveolar macrophages and may serve as therapeutic target for emphysema and chronic obstructive pulmonary disease.
Fri Jan 14 00:00:00 EST 2022
PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation.
Frontiers in cellular neuroscience
Ripamonti M,Santambrogio P,Racchetti G,Cozzi A,Di Meo I,Tiranti V,Levi S
13-6800 was used in Western Blotting to demonstrate that the impairment of CoA biosynthesis could interfere with pivotal intracellular mechanisms involved in membrane fusions and vesicular trafficking, leading to an aberrant transferrin receptor-mediated iron uptake.
Sat Jul 16 00:00:00 EDT 2022
Pantothenate and L-Carnitine Supplementation Improves Pathological Alterations in Cellular Models of KAT6A Syndrome.
Genes
Munuera-Cabeza M,Álvarez-Córdoba M,Suárez-Rivero JM,Povea-Cabello S,Villalón-García I,Talaverón-Rey M,Suárez-Carrillo A,Reche-López D,Cilleros-Holgado P,Piñero-Pérez R,Sánchez-Alcázar JA
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to suggest that pantothenate and L-carnitine can significantly improve the mutant phenotype in cellular models of KAT6A syndrome.
Tue Dec 06 00:00:00 EST 2022
Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in Thioacetamide-induced Acute Liver Injury in Mice.
Frontiers in pharmacology
Jiang H,Zhang X,Yang W,Li M,Wang G,Luo Q
13-6800 was used in Western Blotting to reveal that the iron accumulation and ferroptosis contributed to TAA-induced ALI pathogenesis.
Sat Jul 16 00:00:00 EDT 2022
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
Nature communications
Simó-Riudalbas L,Offner S,Planet E,Duc J,Abrami L,Dind S,Coudray A,Coto-Llerena M,Ercan C,Piscuoglio S,Andersen CL,Bramsen JB,Trono D
13-6800 was used in Flow cytometry/Cell sorting to determine that POU5F1B, in spite of its phylogenetic relationship with the POU5F1/OCT4 transcription factor, is a membrane-enriched protein that associates with protein kinases and known targets or interactors as well as with cytoskeleton-related molecules, and induces intracellular signaling events and the release of trans-acting factors involved in cell growth and cell adhesion.
Sat Aug 20 00:00:00 EDT 2022
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Cell research
Hu A,Zhang JZ,Wang J,Li CC,Yuan M,Deng G,Lin ZC,Qiu ZP,Liu HY,Wang XW,Wei PC,He X,Zhao X,Qiu WW,Song BL
13-6800 was used in Immunocytochemistry to reveal the unique autocatalytic mechanism of SMO cholesterylation and an unprecedented role of calcium in Hh signaling.
Tue Mar 01 00:00:00 EST 2022
Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis.
Oxidative medicine and cellular longevity
Ma PW,Wang WL,Chen JW,Yuan H,Lu PH,Gao W,Ding XR,Lun YQ,Liang R,He ZH,Yang Q,Lu LJ
13-6890 was used in Western Blotting to investigate the protective effect of the ferroptosis inhibitor ferrostatin-1 (Fer-1) on NIHL in vivo in CBA/J mice and investigate the protective effect of Fer-1 on tert-butyl hydroperoxide (TBHP)-induced hair cell damage in vitro in cochlear explants and HEI-OC1 cells.
Tue Dec 20 00:00:00 EST 2022
MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma.
Cell stress
Floros KV,Chawla AT,Johnson-Berro MO,Khatri R,Stamatouli AM,Boikos SA,Dozmorov MG,Cowart LA,Faber AC
13-6800 was used in Western Blotting to propose that MYCN orchestrates both enhanced cystine uptake and enhanced activity of the transsulfuration pathway to counteract increased reactive oxygen species (ROS) from iron-induced Fenton reactions, ultimately contributing to a ferroptosis vulnerability in MYCN-amplified neuroblastoma.
Tue Feb 01 00:00:00 EST 2022
Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway.
Life (Basel, Switzerland)
Li ZD,Geng MY,Dou SR,Wang X,Zhang ZH,Chang YZ
13-6800 was used in Western Blotting to suggest that caffeine decreases hepcidin expression via inhibiting inflammation and the activation of the IL-6/STAT3 pathway, thus presenting an attractive, potential therapeutic for the treatment of anemia of inflammation.
Sun Jul 10 00:00:00 EDT 2022
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Cell reports
Gerosa L,Mazzoleni S,Rusconi F,Longaretti A,Lewerissa E,Pelucchi S,Murru L,Giannelli SG,Broccoli V,Marcello E,Kasri NN,Battaglioli E,Passafaro M,Bassani S
13-6800 was used in Western Blotting to support a model whereby PCDH19 favors maintenance of neuronal homeostasis via negative feedback regulation of IEG expression and provide a key to interpreting PCDH19-related hyperexcitability.
Tue May 24 00:00:00 EDT 2022
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Human molecular genetics
Paul F,Ng C,Mohamad Sahari UB,Nafissi S,Nilipoor Y,Tavasoli AR,Bonnard C,Wong PM,Nabavizadeh N,Altunoğlu U,Estiar MA,Majoie CB,Lee H,Nelson SF,Gan-Or Z,Rouleau GA,Van Veldhoven PP,Massie R,Hennekam RC,Kariminejad A,Reversade B
13-6800 was used in Western Blotting to present clinical, genetic, cellular and biochemical evidence that two distinct RBSN missense variants are responsible for a novel Mendelian disorder consisting of progressive muscle weakness, facial dysmorphisms, ophthalmoplegia and intellectual disability.
Fri Oct 28 00:00:00 EDT 2022
Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner.
International journal of molecular sciences
Gu W,Fillebeen C,Pantopoulos K
13-6800 was used in Western Blotting to investigate human IRP1 for evidence of translocation to the nucleus.
Thu Sep 15 00:00:00 EDT 2022
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
iScience
Asraf H,Bogdanovic M,Gottesman N,Sekler I,Aizenman E,Hershfinkel M
13-6800 was used in Western Blot, Immunoprecipitation to demonstrate that the neuronal K+/Cl- cotransporter 2 (KCC2) interacts with the SNARE protein synaptosome-associated protein 23 (SNAP23).
Fri Feb 18 00:00:00 EST 2022
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
iScience
Asraf H,Bogdanovic M,Gottesman N,Sekler I,Aizenman E,Hershfinkel M
13-6800 was used in Western Blot, Immunoprecipitation to demonstrate that the neuronal K+/Cl- cotransporter 2 (KCC2) interacts with the SNARE protein synaptosome-associated protein 23 (SNAP23).
Fri Feb 18 00:00:00 EST 2022
VHHs as tools for therapeutic protein delivery to the central nervous system.
Fluids and barriers of the CNS
Wouters Y,Jaspers T,Rué L,Serneels L,De Strooper B,Dewilde M
13-6890 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to suggest the mouse-specific VHH as a valuable research tool in mice and the human-specific VHH as a moiety to enhance the delivery efficiency of therapeutics into the CNS in human patients.
Mon Oct 03 00:00:00 EDT 2022
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.
Cancer discovery
Hong X,Roh W,Sullivan RJ,Wong KHK,Wittner BS,Guo H,Dubash TD,Sade-Feldman M,Wesley B,Horwitz E,Boland GM,Marvin DL,Bonesteel T,Lu C,Aguet F,Burr R,Freeman SS,Parida L,Calhoun K,Jewett MK,Nieman LT,Hacohen N,Näär AM,Ting DT,Toner M,Stott SL,Getz G,Maheswaran S,Haber DA
13-6800 was used in Western Blotting to show that single CTCs from melanoma patients coordinately upregulate lipogenesis and iron homeostasis pathways.
Mon Mar 01 00:00:00 EST 2021
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity.
Cell metabolism
Zhang Z,Funcke JB,Zi Z,Zhao S,Straub LG,Zhu Y,Zhu Q,Crewe C,An YA,Chen S,Li N,Wang MY,Ghaben AL,Lee C,Gautron L,Engelking LJ,Raj P,Deng Y,Gordillo R,Kusminski CM,Scherer PE
13-6890 was used in Immunohistochemistry-immunofluorescence to highlight an important role of adipocyte iron in the maintenance of systemic metabolism through an adipocyte-enterocyte axis.
Tue Aug 03 00:00:00 EDT 2021
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Cell metabolism
Wu CT,Lidsky PV,Xiao Y,Lee IT,Cheng R,Nakayama T,Jiang S,Demeter J,Bevacqua RJ,Chang CA,Whitener RL,Stalder AK,Zhu B,Chen H,Goltsev Y,Tzankov A,Nayak JV,Nolan GP,Matter MS,Andino R,Jackson PK
13-6800 was used in Immunocytochemistry to investigate if SARS-CoV-2 can directly induce β cell killing.
Tue Aug 03 00:00:00 EDT 2021
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
The Journal of cell biology
Wouters R,Michiels C,Sannerud R,Kleizen B,Dillen K,Vermeire W,Ayala AE,Demedts D,Schekman R,Annaert W
13-6800 was used in Western Blot to conclude that dimeric subcomplexes aided by Sec24 paralog selectivity support a stepwise assembly of γ-secretase, controlling final levels in post-Golgi compartments.
Mon Sep 06 00:00:00 EDT 2021
Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides.
Pain
Huang H,Tay SH,Ng W,Ng SY,Soong TW
13-6800 was used in Western Blotting to study the effect of targeting alternative splicing of hTRPA1 for treating neurogenic problems.
Thu Jul 01 00:00:00 EDT 2021
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
PLoS pathogens
Cerny O,Godlee C,Tocci R,Cross NE,Shi H,Williamson JC,Alix E,Lehner PJ,Holden DW
13-6800 was used in Immunoprecipitation to find that SteD targets the plasma membrane protein CD97 for degradation by a similar mechanism.
Thu Jul 01 00:00:00 EDT 2021
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Frontiers in oncology
Liu WJ,Pan PY,Sun Y,Wang JB,Zhou H,Xie X,Duan ZY,Dong HY,Chen WN,Zhang LD,Wang C
13-6800 was used in Western Blot to provide a solid basis for targeting mitochondria iron metabolism in cisplatin-resistant NSCLC for therapeutic purposes.
Tue Feb 08 00:00:00 EST 2022
RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11.
Journal of cell science
Osaki F,Matsui T,Hiragi S,Homma Y,Fukuda M
13-6800 was used in Immunocytochemistry to bioengineer an artificial Rab11-specific binding domain, named RBD11.
Thu Apr 01 00:00:00 EDT 2021
Correlation Analyses of Clinical Manifestations and Variant Effects in KCNB1-Related Neurodevelopmental Disorder.
Frontiers in pediatrics
Xiong J,Liu Z,Chen S,Kessi M,Chen B,Duan H,Deng X,Yang L,Peng J,Yin F
13-6800 was used in Western Blot to investigate clinical presentations and variant effects associations in the disorder.
Sun Sep 17 00:00:00 EDT 2023
Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta.
Current developments in nutrition
Cao C,Fleming MD
13-6800 was used in Immunohistochemistry to show transferrin-dependent iron transport machinery is distinct in different placental cells.
Thu Apr 01 00:00:00 EDT 2021
The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.
The Journal of nutrition
Helman SL,Wilkins SJ,McKeating DR,Perkins AV,Whibley PE,Cuffe JSM,Simmons DG,Fuqua BK,Vulpe CD,Wallace DF,O'Callaghan JL,Pelzer ES,Anderson GJ,Frazer DM
13-6890 was used in Western Blotting to indicate that Zp is not essential for the efficient transfer of iron to the fetus in mice and is localized predominantly in the maternal decidua.
Sat Sep 04 00:00:00 EDT 2021
Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
International journal of molecular sciences
Ilic K,Lin X,Malci A,Stojanović M,Puljko B,Rožman M,Vukelić Ž,Heffer M,Montag D,Schnaar RL,Kalanj-Bognar S,Herrera-Molina R,Mlinac-Jerkovic K
13-6800 was used in Immunocytochemistry-immunoflourescence to test the hypothesis that PMCA-Neuroplastin complexes exist in specific ganglioside-containing rafts, which could affect calcium homeostasis.
Sat Dec 18 00:00:00 EST 2021
Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.
Scientific reports
Shekoohi S,Rajasekaran S,Patel D,Yang S,Liu W,Huang S,Yu X,Witt SN
13-6800 was used in Western Blotting to probe the function of α-syn in melanoma.
Thu Mar 04 00:00:00 EST 2021
The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.
Molecules (Basel, Switzerland)
Schuren ABC,Boer IGJ,Bouma EM,Van de Weijer ML,Costa AI,Hubel P,Pichlmair A,Lebbink RJ,Wiertz EJHJ
13-6800 was used in Western Blot to identify novel cellular factors associated with ER-associated protein degradation.
Fri Jan 08 00:00:00 EST 2021
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
Cancers
Rensi N,Sammarco A,Moccia V,Calore A,Torrigiani F,Prosperi D,Rizzuto MA,Bellini M,De Maria R,Bonsembiante F,Ferro S,Zanetti R,Zappulli V,Cavicchioli L
13-6890 was used in Flow cytometry/Cell sorting to suggest that the use of engineered bionanocages also offers unprecedented opportunities for selective targeted chemotherapy of solid tumors in veterinary medicine.
Fri Mar 12 00:00:00 EST 2021
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
Cancers
Rensi N,Sammarco A,Moccia V,Calore A,Torrigiani F,Prosperi D,Rizzuto MA,Bellini M,De Maria R,Bonsembiante F,Ferro S,Zanetti R,Zappulli V,Cavicchioli L
13-6890 was used in Flow cytometry/Cell sorting to suggest that the use of engineered bionanocages also offers unprecedented opportunities for selective targeted chemotherapy of solid tumors in veterinary medicine.
Fri Mar 12 00:00:00 EST 2021
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
Cancers
Rensi N,Sammarco A,Moccia V,Calore A,Torrigiani F,Prosperi D,Rizzuto MA,Bellini M,De Maria R,Bonsembiante F,Ferro S,Zanetti R,Zappulli V,Cavicchioli L
13-6890 was used in Flow cytometry/Cell sorting to suggest that the use of engineered bionanocages also offers unprecedented opportunities for selective targeted chemotherapy of solid tumors in veterinary medicine.
Fri Mar 12 00:00:00 EST 2021
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
Cancers
Rensi N,Sammarco A,Moccia V,Calore A,Torrigiani F,Prosperi D,Rizzuto MA,Bellini M,De Maria R,Bonsembiante F,Ferro S,Zanetti R,Zappulli V,Cavicchioli L
13-6890 was used in Flow cytometry/Cell sorting to suggest that the use of engineered bionanocages also offers unprecedented opportunities for selective targeted chemotherapy of solid tumors in veterinary medicine.
Fri Mar 12 00:00:00 EST 2021
Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.
JCI insight
Wang HG,Bavley CC,Li A,Jones RM,Hackett J,Bayleyen Y,Lee FS,Rajadhyaksha AM,Pitt GS
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to investigate autism-associated behaviour effects by Scn2a.
Mon Aug 09 00:00:00 EDT 2021
Mapping Receptor Antibody Endocytosis and Trafficking in Brain Endothelial Cells.
Methods in molecular biology (Clifton, N.J.)
Holst MR,Nielsen SSE,Nielsen MS
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to describe how endocytic activity and subcellular trafficking of a specific receptor in brain endothelial cells can be characterized in three steps.
Wed Jan 12 00:00:00 EST 2022
H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis.
Free radical biology & medicine
Asperti M,Bellini S,Grillo E,Gryzik M,Cantamessa L,Ronca R,Maccarinelli F,Salvi A,De Petro G,Arosio P,Mitola S,Poli M
13-6800 was used in Western Blotting to investigate mitochondrial respiration and ferritin function as biomarkers of ferroptosis sensitivity of HepG2 and HA22T/VGH, two Hepatocellular Carcinoma (HCC) cell line models.
Tue Jun 01 00:00:00 EDT 2021
Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice.
eLife
Ito J,Omiya S,Rusu MC,Ueda H,Murakawa T,Tanada Y,Abe H,Nakahara K,Asahi M,Taneike M,Nishida K,Shah AM,Otsu K
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to find that ferrostatin-1, significantly mitigated the development of pressure overload-induced dilated cardiomyopathy in wild-type mice.
Tue Feb 02 00:00:00 EST 2021
Tissue-Specific Regulation of Ferroportin in Wild-Type and Hjv-/- Mice Following Dietary Iron Manipulations.
Hepatology communications
Katsarou A,Gkouvatsos K,Fillebeen C,Pantopoulos K
13-6800 was used in Western Blotting to show that dietary iron differentially affects ferroportin expression in mouse tissues and are consistent with hepcidin-dependent and hepcidin-independent mechanisms for ferroportin regulation.
Wed Dec 01 00:00:00 EST 2021
HCV-Induced Immunometabolic Crosstalk in a Triple-Cell Co-Culture Model Capable of Simulating Systemic Iron Homeostasis.
Cells
Foka P,Dimitriadis A,Karamichali E,Kochlios E,Eliadis P,Valiakou V,Koskinas J,Mamalaki A,Georgopoulou U
13-6800 was used in Western Blotting to suggest the presence of a link between iron homeostasis and innate immunity unfolding among liver, intestine, and macrophages, which could participate in the deregulation of innate immune responses observed in early Hepatitis C virus (HCV) infection.
Mon Aug 30 00:00:00 EDT 2021
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Cell host & microbe
Alix E,Godlee C,Cerny O,Blundell S,Tocci R,Matthews S,Liu M,Pruneda JN,Swatek KN,Komander D,Sleap T,Holden DW
13-6800 was used in Western Blotting to show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembrane protein of unknown biochemical function, TMEM127, are required for SteD-dependent ubiquitination of mMHCII.
Wed Jul 08 00:00:00 EDT 2020
CD44 regulates epigenetic plasticity by mediating iron endocytosis.
Nature chemistry
Müller S,Sindikubwabo F,Cañeque T,Lafon A,Versini A,Lombard B,Loew D,Wu TD,Ginestier C,Charafe-Jauffret E,Durand A,Vallot C,Baulande S,Servant N,Rodriguez R
13-6800 was used in Western Blot to report the discovery that CD44 mediates the endocytosis of iron-bound hyaluronates in tumorigenic cell lines, primary cancer cells and tumours.
Thu Oct 01 00:00:00 EDT 2020
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Neuron
Nguyen TA,Wu K,Pandey S,Lehr AW,Li Y,Bemben MA,Badger JD,Lauzon JL,Wang T,Zaghloul KA,Thurm A,Jain M,Lu W,Roche KW
13-6800 was used in Western Blot to reveal a potential pathogenic mechanism for male bias in NLGN4X-associated ASD.
Wed Jun 03 00:00:00 EDT 2020
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
The EMBO journal
Kruse T,Gnosa SP,Nasa I,Garvanska DH,Hein JB,Nguyen H,Samsøe-Petersen J,Lopez-Mendez B,Hertz EPT,Schwarz J,Pena HS,Nikodemus D,Kveiborg M,Kettenbach AN,Nilsson J
13-6800 was used in Western Blot to provide a roadmap for the identification of phosphatase substrates and reveals unexpected mechanisms governing PP2A dephosphorylation site specificity and tumor suppressor function.
Wed Jul 01 00:00:00 EDT 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
The EMBO journal
Weinert S,Gimber N,Deuschel D,Stuhlmann T,Puchkov D,Farsi Z,Ludwig CF,Novarino G,López-Cayuqueo KI,Planells-Cases R,Jentsch TJ
13-6890 was used in Immunocytochemistry-immunoflourescence to generate Clcn3unc/unc mice in which ClC-3 is converted into a Cl- channel.
Mon May 04 00:00:00 EDT 2020
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
The EMBO journal
Moissoglu K,Stueland M,Gasparski AN,Wang T,Jenkins LM,Hastings ML,Mili S
13-6800 was used in Western Blotting to investigate the functional role of RNA localization at cellular protrusions of migrating mesenchymal cells, using as a model the RAB13 RNA, which encodes a GTPase important for vesicle-mediated membrane trafficking.
Mon Nov 02 00:00:00 EST 2020
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Developmental cell
Jia J,Claude-Taupin A,Gu Y,Choi SW,Peters R,Bissa B,Mudd MH,Allers L,Pallikkuth S,Lidke KA,Salemi M,Phinney B,Mari M,Reggiori F,Deretic V
13-6800 was used in Western Blot, Immunocytochemistry to show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage.
Mon Jan 06 00:00:00 EST 2020
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Developmental cell
Jia J,Claude-Taupin A,Gu Y,Choi SW,Peters R,Bissa B,Mudd MH,Allers L,Pallikkuth S,Lidke KA,Salemi M,Phinney B,Mari M,Reggiori F,Deretic V
13-6800 was used in Western Blot, Immunocytochemistry to show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage.
Mon Jan 06 00:00:00 EST 2020
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Autophagy
Salazar G,Cullen A,Huang J,Zhao Y,Serino A,Hilenski L,Patrushev N,Forouzandeh F,Hwang HS
13-6800 was used in Western Blot to investigate the role of the mitochondrial regulator PPARGC1A and SQSTM1/p62 in autophagy and senescence.
Mon Jun 01 00:00:00 EDT 2020
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
American journal of human genetics
Rodger C,Flex E,Allison RJ,Sanchis-Juan A,Hasenahuer MA,Cecchetti S,French CE,Edgar JR,Carpentieri G,Ciolfi A,Pantaleoni F,Bruselles A,Onesimo R,Zampino G,Marcon F,Siniscalchi E,Lees M,Krishnakumar D,McCann E,Yosifova D,Jarvis J,Kruer MC,Marks W,Campbell J,Allen LE,Gustincich S,Raymond FL,Tartaglia M,Reid E
13-6800 was used in Immunocytochemistry to characterize a distinct multisystem disorder caused by mutations affecting VPS4A and demonstrate that its normal function is required for multiple human developmental and cellular processes.
Thu Dec 03 00:00:00 EST 2020
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
American journal of human genetics
Rodger C,Flex E,Allison RJ,Sanchis-Juan A,Hasenahuer MA,Cecchetti S,French CE,Edgar JR,Carpentieri G,Ciolfi A,Pantaleoni F,Bruselles A,Onesimo R,Zampino G,Marcon F,Siniscalchi E,Lees M,Krishnakumar D,McCann E,Yosifova D,Jarvis J,Kruer MC,Marks W,Campbell J,Allen LE,Gustincich S,Raymond FL,Tartaglia M,Reid E
13-6800 was used in Immunocytochemistry to characterize a distinct multisystem disorder caused by mutations affecting VPS4A and demonstrate that its normal function is required for multiple human developmental and cellular processes.
Thu Dec 03 00:00:00 EST 2020
Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice.
Hypertension (Dallas, Tex. : 1979)
Yasumura S,Naito Y,Okuno K,Sawada H,Asakura M,Masuyama T,Ishihara M
13-6800 was used in Immunohistochemistry to suggest that TfR1 plays an important role in the development of renal fibrosis.
Sat Feb 01 00:00:00 EST 2020
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+ /NADH ratios.
British journal of pharmacology
Wu Z,Palanimuthu D,Braidy N,Salikin NH,Egan S,Huang MLH,Richardson DR
13-6890 was used in Western Blotting to synthesise 20 novel multifunctional agents based on the nicotinoyl hydrazone scaffold, which acts as a metal chelator and a lipophilic delivery vehicle, donating a NAD+ precursor to cells, to target metal dyshomeostasis, oxidative stress, β-amyloid (Aβ) aggregation, and a decrease in the NAD+ /NADH ratio.
Fri May 01 00:00:00 EDT 2020
Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed.
Blood advances
Renassia C,Louis S,Cuvellier S,Boussetta N,Deschemin JC,Borderie D,Bailly K,Poupon J,Dang PM,El-Benna J,Manceau S,Lefrère F,Vaulont S,Peyssonnaux C
13-6800 was used in Western Blotting to characterize neutrophil iron homeostasis and associated functions in patients with hereditary hemochromatosis (HH).
Tue Aug 25 00:00:00 EDT 2020
β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway.
Oxidative medicine and cellular longevity
Lv H,Zhen C,Liu J,Shang P
13-6800 was used in Western Blotting to investigate the effect of β-Phenethyl isothiocyanate (PEITC) on human osteosarcoma both in vitro and in vivo.
Mon Jan 04 00:00:00 EST 2021
Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef.
Journal of virology
Tavares LA,de Carvalho JV,Costa CS,Silveira RM,de Carvalho AN,Donadi EA,daSilva LLP
13-6800 was used in Western Blotting to study the importance of AP-1 isoforms in Nef-mediated depletion of surface HLA-A molecules in T cells.
Tue Mar 17 00:00:00 EDT 2020
Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1.
Journal of cell science
Curnock R,Cullen PJ
13-6890 was used in Western Blotting to how that in response to fluctuating extracellular copper, retromer controls the delivery of CTR1 to the cell surface.
Tue Aug 25 00:00:00 EDT 2020
Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells.
Journal of cell science
Fujii S,Kurokawa K,Inaba R,Hiramatsu N,Tago T,Nakamura Y,Nakano A,Satoh T,Satoh AK
13-6800 was used in Immunocytochemistry to indicate that fly and mammalian recycling endosomes are organelles that are equivalent to trans-Golgi networks in plants.
Wed Feb 26 00:00:00 EST 2020
PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
Molecular biology of the cell
Foltz L,Palacios-Moreno J,Mayfield M,Kinch S,Dillon J,Syrenne J,Levy T,Grimes M
13-6800 was used in Western Blotting to demonstrate that PAG1 directs SFK intracellular localization to control activity and to mediate signaling by RTKs that induce neuronal differentiation.
Tue Sep 15 00:00:00 EDT 2020
EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.
Molecular biology of the cell
Topalidou I,Cattin-Ortolá J,Hummer B,Asensio CS,Ailion M
13-6800 was used in Immunocytochemistry to determine the role of mammalian EIPR1 in insulinoma cells.
Wed Jan 01 00:00:00 EST 2020
Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder.
Alcohol (Fayetteville, N.Y.)
Kwan STC,Kezer CA,Helfrich KK,Saini N,Huebner SM,Flentke GR,Kling PJ,Smith SM
13-6890 was used in Western Blot to conclude that alcohol induces placental insufficiency and is associated with a pro-inflammatory cytokine profile exacerbated by maternal ID and mitigated by maternal IF.
Fri May 01 00:00:00 EDT 2020
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human.
Fluids and barriers of the CNS
Zhang W,Liu QY,Haqqani AS,Leclerc S,Liu Z,Fauteux F,Baumann E,Delaney CE,Ly D,Star AT,Brunette E,Sodja C,Hewitt M,Sandhu JK,Stanimirovic DB
13-6800 was used in Western Blotting to provide a molecular transcriptomics map of key receptor-mediated transcytosis (RMT) receptors in mouse and human brain microvessels and peripheral tissues, important to translational studies of biodistribution, efficacy and safety of antibodies developed against these receptors.
Wed Jul 22 00:00:00 EDT 2020
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
JCI insight
Yang L,Shivakumar P,Kinder J,Way SS,Donnelly B,Mourya R,Luo Z,Bezerra JA
13-6800 was used in Immunohistochemistry to examine the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age.
Thu Jun 04 00:00:00 EDT 2020
Heme Oxygenase-1 Supports Mitochondrial Energy Production and Electron Transport Chain Activity in Cultured Lung Epithelial Cells.
International journal of molecular sciences
Carr JF,Garcia D,Scaffa A,Peterson AL,Ghio AJ,Dennery PA
13-6800 was used in western blotting to show that HO-1 supports essential functions of mitochondria, which highlights the protective effects of HO-1 in diverse pathologies and tissue types. Our results suggest that regulation of heme may be an equally significant role of HO-1.
Tue Sep 22 00:00:00 EDT 2020
Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood-Brain Barrier in vivo and in vitro.
Frontiers in physiology
Burek M,Burmester S,Salvador E,Möller-Ehrlich K,Schneider R,Roewer N,Nagai M,Förster CY
13-6800 was used in Western Blotting to creat an in vitro co-culture model based on human kidney cells of the proximal tubule (HK-2) and brain microvascular endothelial cells (BMEC) and use it to study the cellular mechanism of kidney and brain crosstalk in renal ischemia/reperfusion injury.
Sun Nov 12 00:00:00 EST 2023
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Cell reports
Pensalfini A,Kim S,Subbanna S,Bleiwas C,Goulbourne CN,Stavrides PH,Jiang Y,Lee JH,Darji S,Pawlik M,Huo C,Peddy J,Berg MJ,Smiley JF,Basavarajappa BS,Nixon RA
13-6800 was used in Western Blot to report that Rab5 overactivation alone recapitulates diverse prodromal and degenerative features of AD.
Tue Nov 24 00:00:00 EST 2020
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis.
Science advances
Verma N,Vinik Y,Saroha A,Nair NU,Ruppin E,Mills G,Karn T,Dubey V,Khera L,Raj H,Maina F,Lev S
13-6800 was used in Western Blot to identify potent combination therapies for TNBC and unveiled ferroptosis as a promising therapeutic strategy.
Sat Aug 01 00:00:00 EDT 2020
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis.
Science advances
Verma N,Vinik Y,Saroha A,Nair NU,Ruppin E,Mills G,Karn T,Dubey V,Khera L,Raj H,Maina F,Lev S
13-6800 was used in Western Blot to identify potent combination therapies for TNBC and unveiled ferroptosis as a promising therapeutic strategy.
Sat Aug 01 00:00:00 EDT 2020
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Fluids and barriers of the CNS
Curtaz CJ,Schmitt C,Herbert SL,Feldheim J,Schlegel N,Gosselet F,Hagemann C,Roewer N,Meybohm P,Wöckel A,Burek M
13-6800 was used in Western Blotting to demonstrate that the CD34+ cell-derived human in vitro blood-brain barrier model can be used as a tool to study the molecular mechanisms underlying cerebrovascular pathologies.
Wed Apr 22 00:00:00 EDT 2020
The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.
The Journal of biological chemistry
Chen LF,Lyons MR,Liu F,Green MV,Hedrick NG,Williams AB,Narayanan A,Yasuda R,West AE
13-6800 was used in Western Blotting to show that knocking down GluN3A in rat hippocampal neurons promotes the inducible transcription of a subset of NMDAR-sensitive genes.
Fri Jun 19 00:00:00 EDT 2020
Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism.
iScience
Liang T,Qian ZM,Mu MD,Yung WH,Ke Y
13-6800 was used in Immunohistochemistry to investigate the role of iron and its accumulation in parkinson's disease and its characteristic pathologies and studied the possible use of the iron modulator hepcidin within therapeutics.
Fri Jul 24 00:00:00 EDT 2020
Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease.
Cell death & disease
Mu MD,Qian ZM,Yang SX,Rong KL,Yung WH,Ke Y
13-6800 was used in Western Blotting to identify GSK-J4, a histone demethylase inhibitor with the ability to cross blood brain barrier, as a potent iron suppressor.
Wed Oct 28 00:00:00 EDT 2020
Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice.
Pharmaceutics
Castellanos DM,Sun J,Yang J,Ou W,Zambon AC,Pardridge WM,Sumbria RK
13-6800 was used in Western Blotting to elucidate the plasma pharmacokinetics and safety of a high-affinity bivalent TfRMAb with a murine constant region following acute and chronic subcutaneous dosing in adult C57BL/6J male mice.
Tue Sep 08 00:00:00 EDT 2020
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism.
Scientific reports
Malak OA,Abderemane-Ali F,Wei Y,Coyan FC,Pontus G,Shaya D,Marionneau C,Loussouarn G
13-6890 was used in Western Blot to suggest that, in eukaryotic NaV channels, the S4-S5L of DI, DII and DIII domains allosterically modulate the activation gate and stabilize its open state.
Fri Apr 03 00:00:00 EDT 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
13-6800 was used in Western Blot to identify dietary polyunsaturated fatty acids (PUFAs) as a trigger of GPX4-restricted mucosal inflammation phenocopying aspects of human Crohn's disease (CD).
Tue Apr 14 00:00:00 EDT 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
13-6800 was used in Western Blot to identify dietary polyunsaturated fatty acids (PUFAs) as a trigger of GPX4-restricted mucosal inflammation phenocopying aspects of human Crohn's disease (CD).
Tue Apr 14 00:00:00 EDT 2020
Transferrin Receptor Is a Specific Ferroptosis Marker.
Cell reports
Feng H,Schorpp K,Jin J,Yozwiak CE,Hoffstrom BG,Decker AM,Rajbhandari P,Stokes ME,Bender HG,Csuka JM,Upadhyayula PS,Canoll P,Uchida K,Soni RK,Hadian K,Stockwell BR
13-6800 was used in Flow cytometry/Cell sorting to find that anti-TfR1 and anti-malondialdehyde adduct antibodies are effective at staining ferroptotic tumor cells in multiple cell culture and tissue contexts.
Tue Mar 10 00:00:00 EDT 2020
Transferrin Receptor Is a Specific Ferroptosis Marker.
Cell reports
Feng H,Schorpp K,Jin J,Yozwiak CE,Hoffstrom BG,Decker AM,Rajbhandari P,Stokes ME,Bender HG,Csuka JM,Upadhyayula PS,Canoll P,Uchida K,Soni RK,Hadian K,Stockwell BR
13-6800 was used in Flow cytometry/Cell sorting to find that anti-TfR1 and anti-malondialdehyde adduct antibodies are effective at staining ferroptotic tumor cells in multiple cell culture and tissue contexts.
Tue Mar 10 00:00:00 EDT 2020
Transferrin Receptor Is a Specific Ferroptosis Marker.
Cell reports
Feng H,Schorpp K,Jin J,Yozwiak CE,Hoffstrom BG,Decker AM,Rajbhandari P,Stokes ME,Bender HG,Csuka JM,Upadhyayula PS,Canoll P,Uchida K,Soni RK,Hadian K,Stockwell BR
13-6800 was used in Flow cytometry/Cell sorting to find that anti-TfR1 and anti-malondialdehyde adduct antibodies are effective at staining ferroptotic tumor cells in multiple cell culture and tissue contexts.
Tue Mar 10 00:00:00 EDT 2020
Transferrin Receptor Is a Specific Ferroptosis Marker.
Cell reports
Feng H,Schorpp K,Jin J,Yozwiak CE,Hoffstrom BG,Decker AM,Rajbhandari P,Stokes ME,Bender HG,Csuka JM,Upadhyayula PS,Canoll P,Uchida K,Soni RK,Hadian K,Stockwell BR
13-6800 was used in Flow cytometry/Cell sorting to find that anti-TfR1 and anti-malondialdehyde adduct antibodies are effective at staining ferroptotic tumor cells in multiple cell culture and tissue contexts.
Tue Mar 10 00:00:00 EDT 2020
Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy.
eLife
Eckert AF,Gao P,Wesslowski J,Wang X,Rath J,Nienhaus K,Davidson G,Nienhaus GU
13-6800 was used in Western Blotting to present a robust approach based on fluorescence correlation spectroscopy with ultra-high speed axial line scanning, yielding precise equilibrium dissociation coefficients of interactions in the Wnt signaling pathway.
Fri May 22 00:00:00 EDT 2020
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
eLife
Escamilla-Ayala AA,Sannerud R,Mondin M,Poersch K,Vermeire W,Paparelli L,Berlage C,Koenig M,Chavez-Gutierrez L,Ulbrich MH,Munck S,Mizuno H,Annaert W
13-6800 was used in Immunocytochemistry-immunoflourescence to highlight the power of super-resolution microscopy for the study of γ-secretase distribution and dynamics in the membrane.
Tue Jul 07 00:00:00 EDT 2020
Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
The Journal of clinical investigation
Schwartz AJ,Das NK,Ramakrishnan SK,Jain C,Jurkovic MT,Wu J,Nemeth E,Lakhal-Littleton S,Colacino JA,Shah YM
13-6800 was used in Western Blotting to elucidate a hetero-tissue crosstalk mechanism, whereby hepatic hepcidin regulates intestinal HIF-2α in iron deficiency, anaemia, and iron overload.
Wed Jan 02 00:00:00 EST 2019
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
The Journal of experimental medicine
Muto Y,Moroishi T,Ichihara K,Nishiyama M,Shimizu H,Eguchi H,Moriya K,Koike K,Mimori K,Mori M,Katayama Y,Nakayama KI
13-6800 was used in Western Blotting to demonstrate that the iron-sensing ubiquitin ligase FBXL5 is a previously unrecognized oncosuppressor in liver carcinogenesis in mice.
Mon Apr 01 00:00:00 EDT 2019
A causal role for TRESK loss of function in migraine mechanisms.
Brain : a journal of neurology
Pettingill P,Weir GA,Wei T,Wu Y,Flower G,Lalic T,Handel A,Duggal G,Chintawar S,Cheung J,Arunasalam K,Couper E,Haupt LM,Griffiths LR,Bassett A,Cowley SA,Cader MZ
13-6800 was used in Western Blotting to identify that the two-pore potassium channel TREK contributes to migraine pathogenesis.
Sun Dec 01 00:00:00 EST 2019
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
EMBO molecular medicine
Jeong SY,Hogarth P,Placzek A,Gregory AM,Fox R,Zhen D,Hamada J,van der Zwaag M,Lambrechts R,Jin H,Nilsen A,Cobb J,Pham T,Gray N,Ralle M,Duffy M,Schwanemann L,Rai P,Freed A,Wakeman K,Woltjer RL,Sibon OC,Hayflick SJ
13-6800 was used in Western Blotting to present a mouse model of PKAN with CoA, iron, and dopamine metabolic defects that can be specifically attributed to loss of pantothenate kinase 2 function.
Sun Dec 01 00:00:00 EST 2019
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Haematologica
Maio N,Kim KS,Holmes-Hampton G,Singh A,Rouault TA
13-6800 was used in Western Blotting to examine the time-dependent consequences of loss of ABCB7.
Sun Sep 01 00:00:00 EDT 2019
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
EMBO reports
Moreau D,Vacca F,Vossio S,Scott C,Colaco A,Paz Montoya J,Ferguson C,Damme M,Moniatte M,Parton RG,Platt FM,Gruenberg J
13-6800 was used in Immunocytochemistry-immunoflourescence to conclude that lysobisphosphatidic acid controls endosomal cholesterol mobilisation and export to cellular destinations.
Mon Jul 01 00:00:00 EDT 2019
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
EMBO reports
Jahng JWS,Alsaadi RM,Palanivel R,Song E,Hipolito VEB,Sung HK,Botelho RJ,Russell RC,Sweeney G
13-6800 was used in Western Blot to show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
Fri Oct 04 00:00:00 EDT 2019
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
EMBO reports
Jahng JWS,Alsaadi RM,Palanivel R,Song E,Hipolito VEB,Sung HK,Botelho RJ,Russell RC,Sweeney G
13-6800 was used in Western Blot to show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
Fri Oct 04 00:00:00 EDT 2019
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gokhale A,Hartwig C,Freeman AAH,Bassell JL,Zlatic SA,Sapp Savas C,Vadlamudi T,Abudulai F,Pham TT,Crocker A,Werner E,Wen Z,Repetto GM,Gogos JA,Claypool SM,Forsyth JK,Bearden CE,Glausier J,Lewis DA,Seyfried NT,Kwong JQ,Faundez V
13-6800 was used in Western Blotting to identify mitochondrial pathways as statistically prioritized ontological terms in the 22q11.2 and the Df(16)A proteomes.
Wed May 01 00:00:00 EDT 2019
The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nishino H,Saito T,Wei R,Takano T,Tsutsumi K,Taniguchi M,Ando K,Tomomura M,Fukuda M,Hisanaga SI
13-6800 was used in Western Blotting to investigate the role of LMTK1 in spine formation.
Wed Nov 27 00:00:00 EST 2019
An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.
mAbs
Chung S,Nguyen V,Lin YL,Lafrance-Vanasse J,Scales SJ,Lin K,Deng R,Williams K,Sperinde G,Li JJ,Zheng K,Sukumaran S,Tesar D,Ernst JA,Fischer S,Lazar GA,Prabhu S,Song A
13-6890 was used in Immunocytochemistry-immunoflourescence to support the utility of this assay as a cost-effective and animal-sparing screening tool for evaluation of mAb-based drug candidates during lead selection, optimization, and process development for desired pharmacokinetic properties.
Mon Jul 01 00:00:00 EDT 2019
SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor.
Journal of cell science
Hasegawa J,Jebri I,Yamamoto H,Tsujita K,Tokuda E,Shibata H,Maki M,Itoh T
13-6800 was used in Immunocytochemistry-immunoflourescence to show phosphoinositide-binding protein SH3YL1 is vesicular localized, prevents EGF trafficking from early to late endosomes, inhibits degradation of EGFR and mediates EGFR sorting into multivesicular bodies in a C-teriminal SH3 domain-dependent manner.
Thu Oct 03 00:00:00 EDT 2019
Disturbed neurotransmitter homeostasis in ether lipid deficiency.
Human molecular genetics
Dorninger F,König T,Scholze P,Berger ML,Zeitler G,Wiesinger C,Gundacker A,Pollak DD,Huck S,Just WW,Forss-Petter S,Pifl C,Berger J
13-6800 was used in Western Blotting to determine the role of plasmalogens in neurotransmission.
Sat Jun 15 00:00:00 EDT 2019
TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke.
Pflugers Archiv : European journal of physiology
Chen B,Gao Y,Wei S,Low SW,Ng G,Yu D,Tu TM,Soong TW,Nilius B,Liao P
13-6800 was used in Western Blotting to demonstrate that TRPM4 blockade could attenuate reperfusion injury in stroke recanalization.
Sun Dec 01 00:00:00 EST 2019
GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin.
Molecular biology of the cell
Ahat E,Xiang Y,Zhang X,Bekier ME,Wang Y
13-6800 was used in Western Blotting to show that disruption of the Golgi structure by GRASP depletion resulted in reduced cell adhesion and migration due to decreased integrin protein synthesis.
Fri Mar 15 00:00:00 EDT 2019
Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway.
Cancer management and research
Cui C,Cheng X,Yan L,Ding H,Guan X,Zhang W,Tian X,Hao C
Thu Oct 01 00:00:00 EDT 2020
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia.
Scientific reports
Okuno K,Naito Y,Yasumura S,Sawada H,Asakura M,Masuyama T,Ishihara M
13-6800 was used in Western Blotting to investigate whether TfR1 deletion attenuates LI formation.
Fri Sep 20 00:00:00 EDT 2019
Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion.
iScience
Komura H,Kakio S,Sasahara T,Arai Y,Takino N,Sato M,Satomura K,Ohnishi T,Nabeshima YI,Muramatsu SI,Kii I,Hoshi M
13-6800 was used in Immunocytochemistry to study the location in neurons where amylospheroids form and how they reach their targets to induce neurodegeneration.
Fri Mar 29 00:00:00 EDT 2019
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin.
Cell reports
Saaber F,Schütz D,Miess E,Abe P,Desikan S,Ashok Kumar P,Balk S,Huang K,Beaulieu JM,Schulz S,Stumm R
13-6800 was used in Western Blotting to demonstrate that phosphorylation regulates atypical chemokine receptor function without Β-arrestin involvement in chemokine sequestration and non-canonical signaling.
Tue Feb 05 00:00:00 EST 2019
Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome.
PloS one
Lagundžin D,Hu WF,Law HCH,Krieger KL,Qiao F,Clement EJ,Drincic AT,Nedić O,Naldrett MJ,Alvarez S,Woods NT
13-6800 was used in Western Blotting to illuminate the role of FANCA in GSIS and its protein interactions regulated by glucose stimulation that may explain the prevalence of Β cell-specific endocrinopathies in FA patients.
Tue Mar 03 00:00:00 EST 2020
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
PloS one
Chadchankar J,Korboukh V,Conway LC,Wobst HJ,Walker CA,Doig P,Jacobsen SJ,Brandon NJ,Moss SJ,Wang Q
13-6800 was used in Western Blotting to study the effects of USP14 inhibition in mammalian cells using small molecule inhibitors and an inactive USP14 mutant C114A.
Mon Mar 23 00:00:00 EDT 2020
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Scientific reports
Paul BT,Tesfay L,Winkler CR,Torti FM,Torti SV
13-6800 was used in Western Blotting to acknowledge that the normal functioning of mitochondria, Fe-S cluster biogenesis, iron homeostasis, mitochondrial respiration and synthesis of heme requires sideroflexin4.
Mon Dec 23 00:00:00 EST 2019
Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1.
The Journal of biological chemistry
Smith CP,Lee WK,Haley M,Poulsen SB,Thévenod F,Fenton RA
13-6800 was used in Immunohistochemistry to study the localisation of transferrin receptor 1 to the apical brush border of the proximal tubule in mouse and rat kidneys.
Fri Apr 26 00:00:00 EDT 2019
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
The Journal of biological chemistry
Poli M,Anower-E-Khuda F,Asperti M,Ruzzenenti P,Gryzik M,Denardo A,Gordts PLSM,Arosio P,Esko JD
13-6800 was used in Western Blotting to demonstrate, in both human and mouse models, the role of hepatic heparan sulfate in regulating the expression of hepcidin, and maintaining iron homeostasis.
Fri Sep 06 00:00:00 EDT 2019
Quantitative proteomics reveals reduction of endocytic machinery components in gliomas.
EBioMedicine
Buser DP,Ritz MF,Moes S,Tostado C,Frank S,Spiess M,Mariani L,Jenö P,Boulay JL,Hutter G
13-6890 was used in Western Blotting to propose that impaired endocytosis creates a selective advantage in glioma tumor progression due to prolonged receptor tyrosine kinase signaling from the cell surface.
Thu Aug 01 00:00:00 EDT 2019
Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.
Scientific reports
Land MA,Chapman HL,Davis-Reyes BD,Felsing DE,Allen JA,Moeller FG,Elferink LA,Cunningham KA,Anastasio NC
13-6890 was used in Western Blot to show a single nucleotide polymorphism of human serotonin 5-HT2C receptor causing the Cys23Ser mutation results in a distinct pharmacological and subcellular localization profile of the receptor versus the wild-type.
Wed Nov 13 00:00:00 EST 2019
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
The Journal of biological chemistry
Lomash RM,Petralia RS,Holtzclaw LA,Tsuda MC,Wang YX,Badger JD,Cameron HA,Youle RJ,Roche KW
13-6800 was used in Western Blotting to conclude that the brain-specific dynamin GTPase neurolastin exhibits stress-responsive localization to mitochondria and is required for proper mitochondrial morphology.
Fri Jul 26 00:00:00 EDT 2019
Sex-regulated gene dosage effect of PPARα on synaptic plasticity.
Life science alliance
Pierrot N,Ris L,Stancu IC,Doshina A,Ribeiro F,Tyteca D,Baugé E,Lalloyer F,Malong L,Schakman O,Leroy K,Kienlen-Campard P,Gailly P,Brion JP,Dewachter I,Staels B,Octave JN
13-6800 was used in Western Blotting to understand mechanisms driving cognitive improvements following nuclear receptor activation.
Mon Apr 01 00:00:00 EDT 2019
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
JCI insight
Shi Y,Hung ST,Rocha G,Lin S,Linares GR,Staats KA,Seah C,Wang Y,Chickering M,Lai J,Sugawara T,Sagare AP,Zlokovic BV,Ichida JK
13-6800 was used in Western Blotting to develop induced motor neuron models from C9ORF72 and sporadic amyotrophic lateral sclerosis patients to identify targets that are effective against these types of cases.
Tue Jul 16 00:00:00 EDT 2019
Extracellular small non-coding RNA contaminants in fetal bovine serum and serum-free media.
Scientific reports
Mannerström B,Paananen RO,Abu-Shahba AG,Moilanen J,Seppänen-Kaijansinkko R,Kaur S
13-6800 was used in Western Blotting to study RNA contamination in foetal bovine serum and serum-free media.
Tue Apr 02 00:00:00 EDT 2019
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors.
The Journal of biological chemistry
Parakala ML,Zhang Y,Modgil A,Chadchankar J,Vien TN,Ackley MA,Doherty JJ,Davies PA,Moss SJ
13-6800 was used in Western Blotting to examine mPRs' role in mediating the effects of NAS on the efficacy of GABAergic inhibition.
Fri Aug 09 00:00:00 EDT 2019
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell reports
Chiu AM,Wang J,Fiske MP,Hubalkova P,Barse L,Gray JA,Sanz-Clemente A
13-6800 was used in Western Blot to find that phosphorylation of GluN2B at S1480 maintains NMDARs at extrasynaptic membranes as part of a protein complex containing protein phosphatase 1 (PP1).
Tue Jul 09 00:00:00 EDT 2019
Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model.
Neuro-oncology advances
Munegowda MA,Fisher C,Molehuis D,Foltz W,Roufaiel M,Bassan J,Nitz M,Mandel A,Lilge L
13-6800 was used in Immunohistochemistry to evaluate the tolerability and efficacy of the Ruthenium-based photosensitizer TLD-1433 with apo-Transferrin in the rat glioma 2 model.
Fri Apr 15 00:00:00 EDT 2022
miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.
Scientific reports
Babu KR,Muckenthaler MU
13-6800 was used in Western Blotting to show that in hepatocellular carcinoma, transferrin receptor 1 expression is regulated by miR-148a.
Wed Feb 06 00:00:00 EST 2019
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.
Cell
Almeida-Souza L,Frank RAW,García-Nafría J,Colussi A,Gunawardana N,Johnson CM,Yu M,Howard G,Andrews B,Vallis Y,McMahon HT
13-6800 was used in Immunocytochemistry to elucidate a molecular mechanism for spatiotemporally linking the plasma membrane to a force-generating actin platform guiding endocytic vesicle maturation.
Thu Jul 12 00:00:00 EDT 2018
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
Cellular and molecular life sciences : CMLS
Mukadam AS,Breusegem SY,Seaman MNJ
13-6800 was used in Western Blotting to investigate whether genes involved in endosomal protein sorting play an important role in regulating amyloid precursor protein processing.
Sun Jul 01 00:00:00 EDT 2018
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.
EMBO reports
Søreng K,Munson MJ,Lamb CA,Bjørndal GT,Pankiv S,Carlsson SR,Tooze SA,Simonsen A
13-6890 was used in Western Blotting to show that the membrane remodelling protein SNX18, previously identified as a positive regulator of autophagy, regulates ATG9A trafficking from recycling endosomes.
Sun Apr 01 00:00:00 EDT 2018
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Neurobiology of disease
Schapansky J,Khasnavis S,DeAndrade MP,Nardozzi JD,Falkson SR,Boyd JD,Sanderson JB,Bartels T,Melrose HL,LaVoie MJ
13-6800 was used in Western Blotting to study the role of neuronal LRRK2 kinase activity in lysosome function and α-synuclein homeostasis.
Thu Mar 01 00:00:00 EST 2018
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Biochimica et biophysica acta. Molecular basis of disease
Lane DJR,Bae DH,Siafakas AR,Suryo Rahmanto Y,Al-Akra L,Jansson PJ,Casero RA,Richardson DR
13-6800 was used in Western Blotting to investigate the metabolic link between iron and polyamine metabolism.
Sat Sep 01 00:00:00 EDT 2018
Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism.
Frontiers in molecular neuroscience
Modi ME,Brooks JM,Guilmette ER,Beyna M,Graf R,Reim D,Schmeisser MJ,Boeckers TM,O'Donnell P,Buhl DL
13-6800 was used in Western Blotting to investigate the phylogenetic conservation of phenotypes resultant of Shank2 loss-of-function in a translationally relevant animal model of autism.
Thu Oct 01 00:00:00 EDT 2020
Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.
Journal of neurochemistry
Haqqani AS,Thom G,Burrell M,Delaney CE,Brunette E,Baumann E,Sodja C,Jezierski A,Webster C,Stanimirovic DB
13-6800 was used in Western Blotting to evaluate the efficiency of transcytosis in vitro and intracellular trafficking in endosomal compartments, in an in vitro blood-brain barrier model for affinity variants of OX26.
Sat Sep 01 00:00:00 EDT 2018
An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.
Neurobiology of aging
Blechingberg J,Poulsen ASA,Kjølby M,Monti G,Allen M,Ivarsen AK,Lincoln SJ,Thotakura G,Vægter CB,Ertekin-Taner N,Nykjær A,Andersen OM
13-6800 was used in Immunocytochemistry to characterise a SORL1 transcript containing a novel exon 30B.
Thu Nov 01 00:00:00 EDT 2018
Dietary Iron Fortification Normalizes Fetal Hematology, Hepcidin, and Iron Distribution in a Rat Model of Prenatal Alcohol Exposure.
Alcoholism, clinical and experimental research
Huebner SM,Helfrich KK,Saini N,Blohowiak SE,Cheng AA,Kling PJ,Smith SM
13-6890 was used in Western Blotting to study the effect of dietary iron fortification during pregnancy on alcohol's disruption of fetal homeostasis.
Fri Jun 01 00:00:00 EDT 2018
Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.
Experimental eye research
Ashok A,Karmakar S,Chandel R,Ravikumar R,Dalal S,Kong Q,Singh N
13-6800 was used in Western Blotting to determine whether the ciliary body transports iron, and if the prion protein facilitates this process as in the outer retina.
Mon Oct 01 00:00:00 EDT 2018
Sensitization of TRPV1 receptors by TNF-α orchestrates the development of vincristine-induced pain.
Oncology letters
Wang Y,Feng C,He H,He J,Wang J,Li X,Wang S,Li W,Hou J,Liu T,Fang D,Xie SQ
13-6800 was used in Western Blotting to elucidate the mechanisms underlying the pathogenesis of vincristine-induced neuropathic pain.
Sun Apr 01 00:00:00 EDT 2018
Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum.
Journal of extracellular vesicles
Kornilov R,Puhka M,Mannerström B,Hiidenmaa H,Peltoniemi H,Siljander P,Seppänen-Kaijansinkko R,Kaur S
13-6800 was used in Western Blotting to investigate different EV-depleted FBS prepared by a novel ultrafiltration-based protocol, by conventionally used overnight ultracentrifugation, or commercially available depleted FBS, and compared them with regular FBS.
Sun Nov 12 00:00:00 EST 2023
A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses.
Scientific reports
Kasprowicz R,Rand E,O'Toole PJ,Signoret N
13-6800 was used in Immunocytochemistry-immunoflourescence to develop a straightforward correlative imaging approach utilising commonly available instrumentation to sample large numbers of cell-cell interaction events.
Tue May 22 00:00:00 EDT 2018
A molecular atlas of cell types and zonation in the brain vasculature.
Nature
Vanlandewijck M,He L,Mäe MA,Andrae J,Ando K,Del Gaudio F,Nahar K,Lebouvier T,Laviña B,Gouveia L,Sun Y,Raschperger E,Räsänen M,Zarb Y,Mochizuki N,Keller A,Lendahl U,Betsholtz C
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to illustrate the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.
Thu Feb 22 00:00:00 EST 2018
Mutant voltage-gated Na+ channels can exert a dominant negative effect through coupled gating.
American journal of physiology. Heart and circulatory physiology
Clatot J,Zheng Y,Girardeau A,Liu H,Laurita KR,Marionneau C,Deschênes I
13-6890 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot, Control to demonstrate that coupled gating of voltage-gated Na+ channels can also be responsible for the dominant negative effect leading to arrhythmias.
Thu Nov 01 00:00:00 EDT 2018
Inflammation-induced iron transport and metabolism by brain microglia.
The Journal of biological chemistry
McCarthy RC,Sosa JC,Gardeck AM,Baez AS,Lee CH,Wessling-Resnick M
13-6800 was used in Western Blotting to characterised uptake of transferrin-bound iron and non-transferrin-bound iron by immortalised microglial cells.
Fri May 18 00:00:00 EDT 2018
CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.
mBio
Vanarsdall AL,Pritchard SR,Wisner TW,Liu J,Jardetzky TS,Johnson DC
13-6800 was used in Functional assay to identify CD147 as an entry mediator for pentamer-expressing human cytomegalovirus into epithelial and endothelial cells.
Tue May 08 00:00:00 EDT 2018
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
eLife
Künzel U,Grieve AG,Meng Y,Sieber B,Cowley SA,Freeman M
13-6800 was used in Western Blotting to examine the role of ADAM17 in the regulated release of multiple cytokine and growth factor signals.
Wed Jun 13 00:00:00 EDT 2018
Tuning of delta-protocadherin adhesion through combinatorial diversity.
eLife
Bisogni AJ,Ghazanfar S,Williams EO,Marsh HM,Yang JY,Lin DM
13-6800 was used in Western Blotting to study how intra- and interfamily delta-protocadherin interactions can greatly amplify the impact of this small subfamily on neuronal function.
Fri Dec 14 00:00:00 EST 2018
Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia.
Frontiers in neuroscience
Ryan F,Zarruk JG,Lößlein L,David S
13-6800 was used in Western Blotting to assess the role of ceruloplasmin in permanent middle cerebral artery occlusion, comparing wildtype and ceruloplasmin null mice.
Wed Sep 30 00:00:00 EDT 2020
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
PloS one
Kurdyukov S,Eccles CA,Desai AA,Gonzalez-Garay M,Yuan JX,Garcia JGN,Rafikova O,Rafikov R
13-6800 was used in Western Blotting to demonstrate that a moderate decrease in glucose-6-phosphate dehydrogenase activity is associated with pulmonary arterial hypertension.
Tue Feb 12 00:00:00 EST 2019
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.
Nature communications
Hirata T,Mishra SK,Nakamura S,Saito K,Motooka D,Takada Y,Kanzawa N,Murakami Y,Maeda Y,Fujita M,Yamaguchi Y,Kinoshita T
13-6800 was used in Western Blotting to identify and examine the structure of a Golgi-resident GPI-N-acetylgalactosamine transferase, and elucidate the initial step of GPI-N-acetylgalactosamine biosynthesis.
Fri Jan 26 00:00:00 EST 2018
Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1.
iScience
Shikanai M,Nishimura YV,Sakurai M,Nabeshima YI,Yuzaki M,Kawauchi T
13-6800 was used in Immunohistochemistry to examine the role of caveolin-1 in the regulation of the in vivo-specific steps of neuronal maturation.
Fri Sep 28 00:00:00 EDT 2018
Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2.
The Journal of biological chemistry
Yang Z,Follett J,Kerr MC,Clairfeuille T,Chandra M,Collins BM,Teasdale RD
13-6800 was used in Western Blotting to reveal a role for SNX27 in glutamine uptake and amino acid-stimulated mTORC1 activation via modulation of ASCT2 intracellular trafficking.
Fri May 04 00:00:00 EDT 2018
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.
eLife
Yoneyama Y,Lanzerstorfer P,Niwa H,Umehara T,Shibano T,Yokoyama S,Chida K,Weghuber J,Hakuno F,Takahashi SI
13-6800 was used in Western Blotting to establish a new role for insulin receptor substrate (IRS)-1 as an endocytic regulator of Insulin-like growth factor (IGF)-I receptor(IR) that ensures sustained IGF bioactivity.
Wed Apr 11 00:00:00 EDT 2018
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
PloS one
Moriwaki Y,Ohno Y,Ishii T,Takamura Y,Kita Y,Watabe K,Sango K,Tsuji S,Misawa H
13-6800 was used in Western Blotting to study the role of small integral membrane protein of the lysosome/late endosome in the physiological regulation of protein trafficking.
Wed Dec 19 00:00:00 EST 2018
Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.
The Journal of biological chemistry
Mygind KJ,Störiko T,Freiberg ML,Samsøe-Petersen J,Schwarz J,Andersen OM,Kveiborg M
13-6800 was used in Western Blotting to determine how intracellular trafficking regulates ADAM9 availability at the cell surface.
Fri May 25 00:00:00 EDT 2018
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Cell reports
Schaffer TB,Smith JE,Cook EK,Phan T,Margolis SS
13-6800 was used in Western Blotting to show that, mediated by ephexin5), PKCε reduces the number of dendritic spines, which are sites of eventual synapse formation on developing dendrites.
Tue Nov 27 00:00:00 EST 2018
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.
Nature communications
Folgueras AR,Freitas-Rodríguez S,Ramsay AJ,Garabaya C,Rodríguez F,Velasco G,López-Otín C
13-6800 was used in Western Blotting to demonstrate that a deficiency in the hepcidin repressor, matriptase-2, is protective against high-fat diet-induced obesity.
Tue Apr 10 00:00:00 EDT 2018
Entry Studies of New World Arenaviruses.
Methods in molecular biology (Clifton, N.J.)
Martínez MG,Forlenza MB,Candurra NA,Cordo SM
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to describe the entry of Junín virus (JUNV), and other New World mammarenavirus members, into mammalian cells.
Mon Jun 11 00:00:00 EDT 2018
Entry Studies of New World Arenaviruses.
Methods in molecular biology (Clifton, N.J.)
Martínez MG,Forlenza MB,Candurra NA,Cordo SM
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to describe the entry of Junín virus (JUNV), and other New World mammarenavirus members, into mammalian cells.
Mon Jun 11 00:00:00 EDT 2018
Entry Studies of New World Arenaviruses.
Methods in molecular biology (Clifton, N.J.)
Martínez MG,Forlenza MB,Candurra NA,Cordo SM
13-6800 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to describe the entry of Junín virus (JUNV), and other New World mammarenavirus members, into mammalian cells.
Mon Jun 11 00:00:00 EDT 2018
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Nature chemistry
Mai TT,Hamaï A,Hienzsch A,Cañeque T,Müller S,Wicinski J,Cabaud O,Leroy C,David A,Acevedo V,Ryo A,Ginestier C,Birnbaum D,Charafe-Jauffret E,Codogno P,Mehrpour M,Rodriguez R
13-6800 was used in Western Blotting to reveal the prevalence of iron homeostasis in breast CSCs, identifying iron and iron-mediated processes as potential targets against these cells.
Sun Oct 01 00:00:00 EDT 2017
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Science signaling
Nystoriak MA,Nieves-Cintrón M,Patriarchi T,Buonarati OR,Prada MP,Morotti S,Grandi E,Fernandes JD,Forbush K,Hofmann F,Sasse KC,Scott JD,Ward SM,Hell JW,Navedo MF
13-6800 was used in Proximity Ligation Assay to identify a subpopulation of the CaV1.2 channel pore-forming subunit (α1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
Tue Jan 24 00:00:00 EST 2017
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia.
The Journal of cell biology
Allison R,Edgar JR,Pearson G,Rizo T,Newton T,Günther S,Berner F,Hague J,Connell JW,Winkler J,Lippincott-Schwartz J,Beetz C,Winner B,Reid E
13-6800 was used in Western Blotting to implicate the failure of the ER-endosome contact process in axonopathy.
Mon May 01 00:00:00 EDT 2017
The role of microsporidian polar tube protein 4 (PTP4) in host cell infection.
PLoS pathogens
Han B,Polonais V,Sugi T,Yakubu R,Takvorian PM,Cali A,Maier K,Long M,Levy M,Tanowitz HB,Pan G,Delbac F,Zhou Z,Weiss LM
13-6800 was used in Western Blotting to show that PTP4 is an important protein competent of the polar tube involved in the mechanism of host cell infection utilised by Microsporidia.
Sat Apr 01 00:00:00 EDT 2017
Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wright R,Newey SE,Ilie A,Wefelmeyer W,Raimondo JV,Ginham R,Mcllhinney RAJ,Akerman CJ
136890 was used in western blot to report that activation of GABAB receptors results in a decrease in potassium-chloride cotransporter protein function
Wed May 31 00:00:00 EDT 2017
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bermingham DP,Hardaway JA,Refai O,Marks CR,Snider SL,Sturgeon SM,Spencer WC,Colbran RJ,Miller DM,Blakely RD
13-6890 was used in Western Blotting to identify genes that dictate the ability of the dopamine transporter to sustain normal levels of dopamine clearance.
Wed Sep 20 00:00:00 EDT 2017
Sphingomyelins and ceramides with VLCPUFAs are excluded from low-density raft-like domains in differentiating spermatogenic cells.
Journal of lipid research
Santiago Valtierra FX,Mateos MV,Aveldaño MI,Oresti GM
13-6800 was used in western blot to investigate the distribution of sphingomyelins and ceramides in rat spermatogenic cells
Wed Mar 01 00:00:00 EST 2017
Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum.
Journal of virology
Cianciola NL,Chung S,Manor D,Carlin CR
13-6800 was used in western blot to demonstrate that RIDalpha utilizes ORP1L to fine-tune lipid raft cholesterol during adenovirus infection
Wed Mar 15 00:00:00 EDT 2017
Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism.
Journal of virology
Day PM,Thompson CD,Lowy DR,Schiller JT
13-6800 was used in Immunocytochemistry-immunoflourescence to reveal a novel antiviral mechanism for interferon-gamma, preventing infectious entry of human papillomavirus 16.
Mon May 15 00:00:00 EDT 2017
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.
Cancer science
Horniblow RD,Bedford M,Hollingworth R,Evans S,Sutton E,Lal N,Beggs A,Iqbal TH,Tselepis C
13-6800 was used in Western Blotting to study the expression of iron regulatory protein-2 in colorectal cancer.
Thu Jun 01 00:00:00 EDT 2017
SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Structure (London, England : 1993)
Xu J,Zhang L,Ye Y,Shan Y,Wan C,Wang J,Pei D,Shu X,Liu J
13-6800 was used in Immunohistofluorescence to study the mechanism by which SNX16 regulates the recycling trafficking of E-cadherin.
Tue Aug 01 00:00:00 EDT 2017
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Experimental neurology
Huang M,Cheng G,Tan H,Qin R,Zou Y,Wang Y,Zhang Y
13-6800 was used in Western Blotting to investigate the underlying mechanisms for the neuroprotective effect of capsaicin.
Fri Sep 01 00:00:00 EDT 2017
EBV MicroRNA BART16 Suppresses Type I IFN Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Hooykaas MJG,van Gent M,Soppe JA,Kruse E,Boer IGJ,van Leenen D,Groot Koerkamp MJA,Holstege FCP,Ressing ME,Wiertz EJHJ,Lebbink RJ
13-6800 was used in Western Blotting to identify EBV-encoded miR-BART16 as a novel viral immune-evasion factor that interferes with the type I interferon signalling pathway.
Mon May 15 00:00:00 EDT 2017
Essential and selective role of SNX12 in transport of endocytic and retrograde cargo.
Journal of cell science
Priya A,Sugatha J,Parveen S,Lacas-Gervais S,Raj P,Gilleron J,Datta S
13-6800 was used in Western Blotting to examine the essential and selective role of SNX12 in the transport of endocytic and retrograde cargo.
Tue Aug 15 00:00:00 EDT 2017
A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.
Molecular and cellular biology
Bruurs LJM,Zwakenberg S,van der Net MC,Zwartkruis FJ,Bos JL
13-6800 was used in immunohistochemistry to study Cdc42 localization during enterocyte polarization
Sat Apr 01 00:00:00 EDT 2017
Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy.
Neurology. Genetics
Calhoun JD,Vanoye CG,Kok F,George AL,Kearney JA
13-6800 was used in Western Blotting to functionally characterise a KCNB1 variant associated with neurodevelopmental disorders.
Fri Dec 01 00:00:00 EST 2017
Effects of epigallocatechin‑3‑gallate on iron metabolism in spinal cord motor neurons.
Molecular medicine reports
Che F,Wang G,Yu J,Wang X,Lu Y,Fu Q,Su Q,Jiang J,Du Y
13-6800 was used in Western Blotting to reveal that EGCG leads to a decrease in oxidative stress levels, leading to motor neuron protection in the organotypic culture of a rat spinal cord; however, EGCG does not alter iron metabolism protein expression regulation.
Fri Sep 01 00:00:00 EDT 2017
Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN).
Frontiers in genetics
Ingrassia R,Memo M,Garavaglia B
136800 was used in western blot to assess a novel method of iron regulation in Neurodegeneration with Brain Iron Accumulation
Wed Sep 30 00:00:00 EDT 2020
Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
eLife
Grieve AG,Xu H,Künzel U,Bambrough P,Sieber B,Freeman M
13-6800 was used in Western Blotting to show that iRhom2 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface by this interaction in mice.
Sat Apr 22 00:00:00 EDT 2017
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.
Nature communications
Rahbek-Clemmensen T,Lycas MD,Erlendsson S,Eriksen J,Apuschkin M,Vilhardt F,Jørgensen TN,Hansen FH,Gether U
13-6800 was used in Western Blotting to show dynamic sequestering of dopamine transporters into cholesterol-dependent nanodomains in dopaminergic neurons.
Fri Sep 29 00:00:00 EDT 2017
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.
eLife
Gao J,Marosi M,Choi J,Achiro JM,Kim S,Li S,Otis K,Martin KC,Portera-Cailliau C,Tontonoz P
13-6800 was used in Western Blotting to demonstrate that the E3 ubiquitin ligase, IDOL, determines synaptic ApoER2 protein levels in response to neuronal activation and regulates dendritic spine morphogenesis and plasticity.
Mon Sep 11 00:00:00 EDT 2017
Novel ecto-tagged integrins reveal their trafficking in live cells.
Nature communications
Huet-Calderwood C,Rivera-Molina F,Iwamoto DV,Kromann EB,Toomre D,Calderwood DA
13-6800 was used in Immunocytochemistry-immunoflourescence to develop Β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to facilitate dye attachment.
Mon Sep 18 00:00:00 EDT 2017
Analysis of Ras/ERK Compartmentalization by Subcellular Fractionation.
Methods in molecular biology (Clifton, N.J.)
Agudo-Ibañez L,Crespo P,Casar B
13-6890 was used in Western Blotting to propose methods for analyzing the subcellular compartmentalization of the members of the Ras/ERK cascade which constitutes an important factor to be taken into account when studying specific biological responses evoked by Ras/ERK signals.
Fri Jan 12 00:00:00 EST 2018
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
PLoS genetics
Dietrich P,Johnson IM,Alli S,Dragatsis I
13-6800 was used in Western Blotting to show that elimination of Htt expression in the adult mouse results in behavioral deficits, progressive neuropathological changes including bilateral thalamic calcification, and altered brain iron homeostasis.
Sat Jul 01 00:00:00 EDT 2017
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery.
The Journal of biological chemistry
Dauner K,Eid W,Raghupathy R,Presley JF,Zha X
13-6800 was used in Immunocytochemistry to investigate whether endocytic recycling requires active mechanistic target of rapamycin.
Fri Apr 07 00:00:00 EDT 2017
Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
eLife
Abrami L,Dallavilla T,Sandoz PA,Demir M,Kunz B,Savoglidis G,Hatzimanikatis V,van der Goot FG
13-6800 was used in Immunoprecipitation to show that human ZDHHC6 is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade.
Tue Aug 15 00:00:00 EDT 2017
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Scientific reports
Raggi C,Gammella E,Correnti M,Buratti P,Forti E,Andersen JB,Alpini G,Glaser S,Alvaro D,Invernizzi P,Cairo G,Recalcati S
13-6800 was used in Western Blotting to identify different expression of iron proteins indicating increased iron content, oxidative stress and higher expression of cancer stem cell markers in Cholangiocarcinoma-SPH.
Fri Dec 15 00:00:00 EST 2017
A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl- co-transporter KCC2 in hippocampal neurons.
The Journal of biological chemistry
Pressey JC,Mahadevan V,Khademullah CS,Dargaei Z,Chevrier J,Ye W,Huang M,Chauhan AK,Meas SJ,Uvarov P,Airaksinen MS,Woodin MA
13-6800 was used in Western Blotting to determine the role of KCC2-protein interactions in regulating total and surface membrane KCC2 expression.
Fri Apr 14 00:00:00 EDT 2017
TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.
PloS one
Oguchi ME,Noguchi K,Fukuda M
13-6800 was used in Immunocytochemistry-immunoflourescence to indicate that TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.
Fri Sep 08 00:00:00 EDT 2017
Na+/H+ Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.
The Journal of biological chemistry
Beydoun R,Hamood MA,Gomez Zubieta DM,Kondapalli KC
13-6800 was used in Western Blotting to identify NHE9 as a novel regulator of iron entry into the brain across the blood-brain barrier.
Fri Mar 10 00:00:00 EST 2017
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Oncotarget
Rychtarcikova Z,Lettlova S,Tomkova V,Korenkova V,Langerova L,Simonova E,Zjablovskaja P,Alberich-Jorda M,Neuzil J,Truksa J
136800 was used in western blot to find the specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response
Tue Jan 24 00:00:00 EST 2017
Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.
Frontiers in physiology
Deschemin JC,Mathieu JRR,Zumerle S,Peyssonnaux C,Vaulont S
13-6800 was used in Western Blotting to show that intraperitoneal LPS injection is not associated with pulmonary hepcidin induction, despite high levels of inflammatory cytokines.
Wed Sep 30 00:00:00 EDT 2020
Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria.
Scientific reports
Marks ES,Bonnemaison ML,Brusnahan SK,Zhang W,Fan W,Garrison JC,Boesen EI
13-6800 was used in Western Blotting to investigate the effect of renal iron accumulation on renal injury in systemic lupus erythematosus in mice.
Mon Oct 09 00:00:00 EDT 2017
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
PloS one
Arber C,Angelova PR,Wiethoff S,Tsuchiya Y,Mazzacuva F,Preza E,Bhatia KP,Mills K,Gout I,Abramov AY,Hardy J,Duce JA,Houlden H,Wray S
13-6800 was used in Immunocytochemistry to suggest that mitochondrial deficiency is a feature of PANK2-neurodegenration and is explained by altered NADH/FADH substrate supply to oxidative phosphorylation.
Mon Oct 23 00:00:00 EDT 2017
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
PloS one
Arber C,Angelova PR,Wiethoff S,Tsuchiya Y,Mazzacuva F,Preza E,Bhatia KP,Mills K,Gout I,Abramov AY,Hardy J,Duce JA,Houlden H,Wray S
13-6800 was used in Immunocytochemistry to suggest that mitochondrial deficiency is a feature of PANK2-neurodegenration and is explained by altered NADH/FADH substrate supply to oxidative phosphorylation.
Mon Oct 23 00:00:00 EDT 2017
Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.
Methods in molecular biology (Clifton, N.J.)
Hivroz C,Larghi P,Jouve M,Ardouin L
13-6800 was used in Western Blotting to describe herein a protocol, which combines a separation of membranes on flotation gradient with an affinity purification of Strep-tagged fusion transmembrane proteins with Strep-Tactin® resin, allowing the purification of membranes containing the Strep-tagged molecule of interest.
Thu Feb 01 00:00:00 EST 2018
A phosphoinositide conversion mechanism for exit from endosomes.
Nature
Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V
13-6800 was used in flow cytometry and immunocytochemistry to study the conversion of phosphatidylinositol 3-phosphate to phosphatidylinositol 4-phosphate at endosomes en route to the plasma membrane
Thu Jan 21 00:00:00 EST 2016
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
136890 was used in western blot to elucidate the role of TfR1 in adaptive immunity
Fri Jan 01 00:00:00 EST 2016
Lrp4 in astrocytes modulates glutamatergic transmission.
Nature neuroscience
Sun XD,Li L,Liu F,Huang ZH,Bean JC,Jiao HF,Barik A,Kim SM,Wu H,Shen C,Tian Y,Lin TW,Bates R,Sathyamurthy A,Chen YJ,Yin DM,Xiong L,Lin HP,Hu JX,Li BM,Gao TM,Xiong WC,Mei L
13-6890 was used in western blot to determine modulation of glutamatergic transmission by Lrp4 in astrocytes
Mon Aug 01 00:00:00 EDT 2016
Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.
Cancer immunology research
Jhaveri DT,Kim MS,Thompson ED,Huang L,Sharma R,Klein AP,Zheng L,Le DT,Laheru DA,Pandey A,Jaffee EM,Anders RA
136890 was used in immunohistochemistry - paraffin section to use SILAC immunoprecipitation to identify antibody targets expressed by vaccinated cancer patients
Tue Mar 01 00:00:00 EST 2016
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.
Free radical biology & medicine
Baksi S,Tripathi AK,Singh N
13-6800 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to characterize modulation of retinal iron homeostasis by facilitating the update of transferrin-bound iron by alpha-synuclein which may be a visual manife
Mon Aug 01 00:00:00 EDT 2016
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
The Journal of cell biology
Horton ER,Humphries JD,Stutchbury B,Jacquemet G,Ballestrem C,Barry ST,Humphries MJ
13-6890 was used in western blot to determine how modulation of FAK and Src adhesion signalling occurs without the need for adhesion complex composition
Mon Feb 01 00:00:00 EST 2016
A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.
Osteoarthritis and cartilage
Gandolfi B,Alamri S,Darby WG,Adhikari B,Lattimer JC,Malik R,Wade CM,Lyons LA,Cheng J,Bateman JF,McIntyre P,Lamandé SR,Haase B
13-6800 was used in western blot to study osteochondrodysplasia in Scottish fold cats by an underlying dominant TRPV4 variant
Mon Aug 01 00:00:00 EDT 2016
African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes.
PLoS pathogens
Hernáez B,Guerra M,Salas ML,Andrés G
136890 was used in immunocytochemistry to study the entry and uncoating of African swine fever virus
Fri Apr 01 00:00:00 EDT 2016
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Neurobiology of disease
Natunen T,Takalo M,Kemppainen S,Leskelä S,Marttinen M,Kurkinen KMA,Pursiheimo JP,Sarajärvi T,Viswanathan J,Gabbouj S,Solje E,Tahvanainen E,Pirttimäki T,Kurki M,Paananen J,Rauramaa T,Miettinen P,Mäkinen P,Leinonen V,Soininen H,Airenne K,Tanzi RE,Tanila H,Haapasalo A,Hiltunen M
13-6800 was used in western blot to compare the relationship between BACE1 and ubiquilin-1 in human Alzheimer's disease, APdE9 transgenic mouse brain and cell-based models
Fri Jan 01 00:00:00 EST 2016
Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity.
Traffic (Copenhagen, Denmark)
Zhao Y,Feresin RG,Falcon-Perez JM,Salazar G
13-6800 was used in immunocytochemistry and western blot to ascertain the role of heterodimerization in zinc transporter sorting in the endolysosomal pathway
Tue Mar 01 00:00:00 EST 2016
Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yang Z,Hong LK,Follett J,Wabitsch M,Hamilton NA,Collins BM,Bugarcic A,Teasdale RD
13-6800 was used in Immunocytochemistry to identify a role for retromer in the glucose transporter 4 storage vesicle formation and adipogenesis.
Tue Mar 01 00:00:00 EST 2016
Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yang Z,Hong LK,Follett J,Wabitsch M,Hamilton NA,Collins BM,Bugarcic A,Teasdale RD
13-6800 was used in Immunocytochemistry to identify a role for retromer in the glucose transporter 4 storage vesicle formation and adipogenesis.
Tue Mar 01 00:00:00 EST 2016
Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.
Experimental neurology
Guo C,Hao LJ,Yang ZH,Chai R,Zhang S,Gu Y,Gao HL,Zhong ML,Wang T,Li JY,Wang ZY
13-6800 was used in western blot to assess prevention of dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice by deferoxamine-mediated up-regulation of HIF-1alpha
Wed Jun 01 00:00:00 EDT 2016
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Journal of cell science
Kurkinen KM,Marttinen M,Turner L,Natunen T,Mäkinen P,Haapalinna F,Sarajärvi T,Gabbouj S,Kurki M,Paananen J,Koivisto AM,Rauramaa T,Leinonen V,Tanila H,Soininen H,Lucas FR,Haapasalo A,Hiltunen M
13-6800 was used in immunocytochemistry and western blot to research the modulation of beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1 by SEPT8
Wed Jun 01 00:00:00 EDT 2016
Atg9A trafficking through the recycling endosomes is required for autophagosome formation.
Journal of cell science
Imai K,Hao F,Fujita N,Tsuji Y,Oe Y,Araki Y,Hamasaki M,Noda T,Yoshimori T
13-6800 was used in Western Blotting to show that the trafficking of autophagy-related protein 9A through the recycling endosomes is an essential step for autophagosome formation.
Sat Oct 15 00:00:00 EDT 2016
The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling.
Journal of cell science
Hendrick J,Franz-Wachtel M,Moeller Y,Schmid S,Macek B,Olayioye MA
13-6800 was used in Western Blotting to propose a new function for Scribble in Rho regulation that entails positioning of DLC3 GAP activity at cell junctions in polarized epithelial cells.
Sat Oct 01 00:00:00 EDT 2016
Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders.
The Journal of nutrition
Huebner SM,Blohowiak SE,Kling PJ,Smith SM
13-6890 was used in western blot to analyze alteration of fetal iron distribution and elevation of hepatic hepcidin in a rat model of fetal alcohol spectrum disorders caused by prenatal alcohol exposure
Wed Jun 01 00:00:00 EDT 2016
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Molecular and cellular neurosciences
Hersom M,Helms HC,Pretzer N,Goldeman C,Jensen AI,Severin G,Nielsen MS,Holm R,Brodin B
136800 was used in immunocytochemistry to examine transferrin receptor expression and the role of transendothelial transferrin transport in cultured bovine brain endothelial cell monolayers
Sat Oct 01 00:00:00 EDT 2016
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
Metabolic brain disease
Stroh MA,Winter MK,Swerdlow RH,McCarson KE,Zhu H
13-6800 was used in western blot to learn about potentiation of behavioral abnormalities, disturbing of iron pathways, and exacerbation of harmaline-induced tremor in mice due to loss of NCB5OR in the cerebellum
Mon Aug 01 00:00:00 EDT 2016
OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.
Molecular biology of the cell
Billcliff PG,Noakes CJ,Mehta ZB,Yan G,Mak L,Woscholski R,Lowe M
13-6800 was used in immunocytochemistry to promote biogenesis of membrane-trafficking intermediates by engagement of OCRL1 with F-BAR protein pacsin 2
Fri Jan 01 00:00:00 EST 2016
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane.
Molecular biology of the cell
Tanaka Y,Ono N,Shima T,Tanaka G,Katoh Y,Nakayama K,Takatsu H,Shin HW
136800 was used in immunocytochemistry and western blot to demonstrate that ATP9A has an important role in recycling from endosomes to the plasma membrane
Thu Dec 01 00:00:00 EST 2016
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane.
Molecular biology of the cell
Tanaka Y,Ono N,Shima T,Tanaka G,Katoh Y,Nakayama K,Takatsu H,Shin HW
136800 was used in immunocytochemistry and western blot to demonstrate that ATP9A has an important role in recycling from endosomes to the plasma membrane
Thu Dec 01 00:00:00 EST 2016
Proteomic analysis of native cerebellar iFGF14 complexes.
Channels (Austin, Tex.)
Bosch MK,Nerbonne JM,Townsend RR,Miyazaki H,Nukina N,Ornitz DM,Marionneau C
13-6890 was used in western blot to study native cerebellar iFGF14 complexes by proteomic analysis
Sun Jul 03 00:00:00 EDT 2016
Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.
Biochemical and biophysical research communications
Ito F,Nishiyama T,Shi L,Mori M,Hirayama T,Nagasawa H,Yasui H,Toyokuni S
13-6800 was used in western blot to study the varying extra-and intracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis
Fri Aug 05 00:00:00 EDT 2016
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Nature communications
Fusté NP,Fernández-Hernández R,Cemeli T,Mirantes C,Pedraza N,Rafel M,Torres-Rosell J,Colomina N,Ferrezuelo F,Dolcet X,Garí E
13-6800 was used in immunocytochemistry and western blot to determine regulation of metastasis and cell invasion through the phosphorylation of paxillin due to cytoplasmic cyclin D1
Mon May 16 00:00:00 EDT 2016
Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy.
Scientific reports
Hu Z,Wang JW,Yu D,Soon JL,de Kleijn DP,Foo R,Liao P,Colecraft HM,Soong TW
136800 was used in western blot to propose that neonatal splice variant of CaV1.2 channels contribute to heart disease
Wed Oct 12 00:00:00 EDT 2016
Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
The Journal of biological chemistry
Nelson JK,Cook EC,Loregger A,Hoeksema MA,Scheij S,Kovacevic I,Hordijk PL,Ovaa H,Zelcer N
13-6800 was used in western blot to examine the role of deubiquitylating enzymes in cholesterol metabolism
Fri Feb 26 00:00:00 EST 2016
Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
Scientific reports
Jiang B,Liu G,Zheng J,Chen M,Maimaitiming Z,Chen M,Liu S,Jiang R,Fuqua BK,Dunaief JL,Vulpe CD,Anderson GJ,Wang H,Chen H
136890 was used in western blot to examine the role of multicopper ferroxidases in the kidney
Mon Dec 19 00:00:00 EST 2016
Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens.
Optics express
Tafteh R,Abraham L,Seo D,Lu HY,Gold MR,Chou KC
136800 was used in immunocytochemistry to image endosomal transferrin receptors in B-lymphocytes.
Mon Oct 03 00:00:00 EDT 2016
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
Nature communications
Egea-Jimenez AL,Gallardo R,Garcia-Pino A,Ivarsson Y,Wawrzyniak AM,Kashyap R,Loris R,Schymkowitz J,Rousseau F,Zimmermann P
13-6800 was used in Immunohistochemistry to show the importance of the syntenin-PIP2 interaction for plasma membrane targeting of Frizzled 7 and c-jun phosphorylation via the PDZ2 domain.
Fri Jul 08 00:00:00 EDT 2016
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Frontiers in neuroscience
Gasperini L,Meneghetti E,Legname G,Benetti F
13-6800 was used in western blot investigate the effect of prion protein absence on copper and iron metabolism during development and adulthood
Wed Sep 30 00:00:00 EDT 2020
Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6.
eLife
Perrody E,Abrami L,Feldman M,Kunz B,Urbé S,van der Goot FG
13-6800 was used in Western Blotting to show that Wnt signaling coreceptor LRP6 folding is promoted by lysine ubiquitination, retaining it in the ER while avoiding degradation.
Tue Oct 18 00:00:00 EDT 2016
Iron, microbiota and colorectal cancer.
Wiener medizinische Wochenschrift (1946)
Ng O
136800 was used in immunohistochemistry to discuss the consequences of iron supplementation in patients with colorectal cancer
Sat Oct 01 00:00:00 EDT 2016
Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors.
Biochimica et biophysica acta
Sierra-Valdez FJ,Ruiz-Suárez JC,Delint-Ramirez I
136890 was used in western blot to determine the in vivo effects of pentobarbital on brain plasma membranes and lipid rafts
Tue Nov 01 00:00:00 EDT 2016
Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
The EMBO journal
Lee S,Uchida Y,Wang J,Matsudaira T,Nakagawa T,Kishimoto T,Mukai K,Inaba T,Kobayashi T,Molday RS,Taguchi T,Arai H
13-6800 was used in immunocytochemistry to study recycling endosome transport requires EHD1 recruitment of phosphatidylserine translocase
Wed Mar 04 00:00:00 EST 2015
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
The EMBO journal
Ruas M,Davis LC,Chen CC,Morgan AJ,Chuang KT,Walseth TF,Grimm C,Garnham C,Powell T,Platt N,Platt FM,Biel M,Wahl-Schott C,Parrington J,Galione A
13-6800 was used in immunocytochemistry to study TPC-deficient cells by expression of Ca2+-permeable two-pore channels and rescue of NAADP signaling
Thu Jul 02 00:00:00 EDT 2015
Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.
Autophagy
Shi Y,Tan SH,Ng S,Zhou J,Yang ND,Koo GB,McMahon KA,Parton RG,Hill MM,Del Pozo MA,Kim YS,Shen HM
13-6800 was used in western blot to characterize the modulation of lysosomal function and autophagy due to CAV1/caveolin-1 in human breast cancer cells after cell stress response
Tue Feb 23 00:00:00 EST 2016
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Chen AC,Donovan A,Ned-Sykes R,Andrews NC
13-6890 was used in western blot to assess how intestinal homeostasis is regulated by a noncanonical role of transferrin receptor 1
Tue Sep 15 00:00:00 EDT 2015
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Science signaling
Chung J,Bauer DE,Ghamari A,Nizzi CP,Deck KM,Kingsley PD,Yien YY,Huston NC,Chen C,Schultz IJ,Dalton AJ,Wittig JG,Palis J,Orkin SH,Lodish HF,Eisenstein RS,Cantor AB,Paw BH
13-6800 was used in western blot to find a developmental role for LAT3 in red blood cells and report that mTORC1 acts as a homeostatic sensor
Tue Apr 14 00:00:00 EDT 2015
Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.
Cellular and molecular life sciences : CMLS
Shi ZH,Shi FF,Wang YQ,Sheftel AD,Nie G,Zhao YS,You LH,Gou YJ,Duan XL,Zhao BL,Xu HM,Li CY,Chang YZ
13-6800 was used in western blot to characterize inhibition of neuronal tumor cell proliferation by mitochondrial ferritin
Sun Mar 01 00:00:00 EST 2015
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways.
eLife
Zheng N,Jeyifous O,Munro C,Montgomery JM,Green WN
13-6800 was used in immunocytochemistry to learn how AMPA receptor trafficking is regulated by synaptic activity through different recycling pathways
Wed May 13 00:00:00 EDT 2015
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
The Journal of cell biology
Bruurs LJ,Donker L,Zwakenberg S,Zwartkruis FJ,Begthel H,Knisely AS,Posthuma G,van de Graaf SF,Paulusma CC,Bos JL
13-6800 was used in immunohistochemistry to examine the role of Cdc42 in enterocyte polarization
Mon Sep 28 00:00:00 EDT 2015
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.
The Journal of cell biology
Chen AC,Kim S,Shepardson N,Patel S,Hong S,Selkoe DJ
13-6800 was used in immunocytochemistry and western blot to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase
Mon Dec 21 00:00:00 EST 2015
LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.
European journal of medicinal chemistry
Alghamdi RH,O'Reilly P,Lu C,Gomes J,Lagace TA,Basak A
13-6800 was used in western blot to discuss the use of PCSK9 as a non-statin cholesterol reducing agent.
Fri Mar 06 00:00:00 EST 2015
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
Neurobiology of disease
Gilad D,Shorer S,Ketzef M,Friedman A,Sekler I,Aizenman E,Hershfinkel M
13-6800 was used in Western Blotting to show that mZnR/GPR39-dependent upregulation of KCC2 activity provides homeostatic adaptation to an excitotoxic stimulus by increasing inhibition.
Tue Sep 01 00:00:00 EDT 2015
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ferreira JS,Schmidt J,Rio P,Águas R,Rooyakkers A,Li KW,Smit AB,Craig AM,Carvalho AL
13-6800 was used in western blot to assess the role of the GluN2B subunit during development and in synaptic plasticity
Wed Jun 03 00:00:00 EDT 2015
Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
Journal of lipid research
Burhans MS,Flowers MT,Harrington KR,Bond LM,Guo CA,Anderson RM,Ntambi JM
13-6890 was used in western blot to investigate the mechanism by which hepatic MUFA production influences adipose tissue stores using transgenic mice
Sun Feb 01 00:00:00 EST 2015
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.
Journal of virology
de Wilde AH,Wannee KF,Scholte FE,Goeman JJ,Ten Dijke P,Snijder EJ,Kikkert M,van Hemert MJ
13-6890 was used in western blot to identify proviral and antiviral host factors in SARS viral replication
Sat Aug 01 00:00:00 EDT 2015
Novel Role of TRPML2 in the Regulation of the Innate Immune Response.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Hua Y,Vergarajauregui S,Diab HI,Puertollano R
13-6800 was used in Immunocytochemistry-immunoflourescence to examine differences in the regulation and distribution of the members of the TRPML family, and identify a novel role for TRPML2 in the innate immune response.
Sun Nov 15 00:00:00 EST 2015
Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor.
Journal of cell science
Jang D,Kwon H,Jeong K,Lee J,Pak Y
13-6800 was used in immunocytochemistry and western blot to investigate flotillin-1-mediated regulation of insulin-like growth factor-1 signaling.
Mon Jun 01 00:00:00 EDT 2015
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
The Journal of biological chemistry
Chen J,Enns CA
13-6800 was used in Western Blotting to examine the role of CD81 in regulating hepcidin expression differently from the BMP and ERK1/2 signalling pathways.
Fri Mar 20 00:00:00 EDT 2015
Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
Scientific reports
David JP,Stas JI,Schmitt N,Bocksteins E
13-6800 was used in immunocytochemistry to characterize Kv2.1/Kv6.4/KCNE5 channel complexes
Wed Aug 05 00:00:00 EDT 2015
Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation.
The Journal of biological chemistry
Dayer C,Stamenkovic I
13-6800 was used in western blot to study the recruitment of MMP-9 to cell surface and its effect on fibroblast differentiation
Fri May 29 00:00:00 EDT 2015
Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.
PloS one
Chen J,Tibroni N,Sauter D,Galaski J,Miura T,Alter G,Mueller B,Haller C,Walker BD,Kirchhoff F,Brumme ZL,Ueno T,Fackler OT
13-6890 was used in western blot to study the behavior of the HIV-1 Vpu alleles in the plasma of elite controller patients
Mon Feb 22 00:00:00 EST 2016
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Molecular neurodegeneration
Sun LH,Yan ML,Hu XL,Peng LW,Che H,Bao YN,Guo F,Liu T,Chen X,Zhang R,Ban T,Wang N,Liu HL,Hou X,Ai J
13-6800 was used in western blot to assess the role of microRNA-9 in regulating Nav1.1/Nav1.2 trafficking under chronic brain hypoperfusion
Tue Aug 11 00:00:00 EDT 2015
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Nature communications
Robertson J,Jacquemet G,Byron A,Jones MC,Warwood S,Selley JN,Knight D,Humphries JD,Humphries MJ
13-6890 was used in western blot to study phosphorylation events at sites of adhesion
Fri Feb 13 00:00:00 EST 2015
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
Redox biology
Mori M,Ito F,Shi L,Wang Y,Ishida C,Hattori Y,Niwa M,Hirayama T,Nagasawa H,Iwase A,Kikkawa F,Toyokuni S
13-6800 was used in immunohistochemistry - paraffin section and western blot to investigate the role of eutopic/ectopic endometrial stromal cells in ovarian endometriosis
Tue Dec 01 00:00:00 EST 2015
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.
Nature medicine
Perdomini M,Belbellaa B,Monassier L,Reutenauer L,Messaddeq N,Cartier N,Crystal RG,Aubourg P,Puccio H
13-6800 was used in western blot to assess the use of gene therapy in treating Friedreich's ataxia cardiomyopathy in a mouse model.
Thu May 01 00:00:00 EDT 2014
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers.
Nature cell biology
Lakshminarayan R,Wunder C,Becken U,Howes MT,Benzing C,Arumugam S,Sales S,Ariotti N,Chambon V,Lamaze C,Loew D,Shevchenko A,Gaus K,Parton RG,Johannes L
13-6890 was used in western blot to show that that Gal3 functionally integrates carbohydrate specificity on cargo proteins.
Sun Jun 01 00:00:00 EDT 2014
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
Nature cell biology
Nijenhuis W,Vallardi G,Teixeira A,Kops GJ,Saurin AT
13-6890 was used in western blot to investigate the regulation of SAC primes kinetochore phosphatases
Mon Dec 01 00:00:00 EST 2014
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.
The Journal of experimental medicine
Bien-Ly N,Yu YJ,Bumbaca D,Elstrott J,Boswell CA,Zhang Y,Luk W,Lu Y,Dennis MS,Weimer RM,Chung I,Watts RJ
13-6800 was used in western blot to report that high-affinity anti-TfR alters TfR trafficking across the blood brain barrier.
Mon Feb 10 00:00:00 EST 2014
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
Current biology : CB
McGough IJ,Steinberg F,Jia D,Barbuti PA,McMillan KJ,Heesom KJ,Whone AL,Caldwell MA,Billadeau DD,Rosen MK,Cullen PJ
13-6890 was used in western blot to study the effect of retromer mutations on endosome-to-TGN transport.
Mon Jul 21 00:00:00 EDT 2014
Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Wang N,Su P,Zhang Y,Lu J,Xing B,Kang K,Li W,Wang Y
13-6800 was used in western blot to study the effect of protein kinase D1-dependent phosphorylation of dopamine D1 receptor on cocaine-induced behavioral responses
Tue Apr 01 00:00:00 EDT 2014
Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.
Journal of molecular biology
Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT
13-6800 was used in immunocytochemistry and western blot to study sorting nexin (SNX) family members interactions with beta integrins
Tue Sep 09 00:00:00 EDT 2014
Stable cell surface expression of GPI-anchored proteins, but not intracellular transport, depends on their fatty acid structure.
Traffic (Copenhagen, Denmark)
Jaensch N,Corrêa IR,Watanabe R
Mon Dec 01 00:00:00 EST 2014
DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles.
Traffic (Copenhagen, Denmark)
Ingle GS,Scales SJ
13-6890 was used in immunocytochemistry to investigate the subcellular trafficking and recycle of CD22
Sat Mar 01 00:00:00 EST 2014
Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.
Journal of immunology (Baltimore, Md. : 1950)
Luteijn RD,Hoelen H,Kruse E,van Leeuwen WF,Grootens J,Horst D,Koorengevel M,Drijfhout JW,Kremmer E,Früh K,Neefjes JJ,Killian A,Lebbink RJ,Ressing ME,Wiertz EJ
13-6800 was used in immunoprecipitation and western blot to demonstrate that CPXV012 inhibits peptide transport by inhibiting ATP binding to the transporter associated with antigen processing
Fri Aug 15 00:00:00 EDT 2014
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.
Neuroscience bulletin
Zhang Y,Wang N,Su P,Lu J,Wang Y
13-6800 was used in western blot to study cocaine-induced behaviors in transgenic mice over-expressing S421A-D1R in the forebrain
Mon Dec 01 00:00:00 EST 2014
Regulation of Rac1 translocation and activation by membrane domains and their boundaries.
Journal of cell science
Moissoglu K,Kiessling V,Wan C,Hoffman BD,Norambuena A,Tamm LK,Schwartz MA
13-6800 was used in western blot to use a fluorescence resonance energy transfer assay to study Rac1 membrane targeting in living cells.
Sun Jun 01 00:00:00 EDT 2014
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
Journal of cell science
McGough IJ,Steinberg F,Gallon M,Yatsu A,Ohbayashi N,Heesom KJ,Fukuda M,Cullen PJ
13-6890 was used in western blot to determine the interactome of human VPS35.
Sat Nov 15 00:00:00 EST 2014
The lipid raft-bound alkaline phosphatase activity increases and the level of transcripts remains unaffected in liver of merosin-deficient LAMA2dy mouse.
Chemico-biological interactions
Montenegro MF,Moral-Naranjo MT,Campoy FJ,Muñoz-Delgado E,Vidal CJ
13-6800 was used in western blot to study the mechanisms underlying the increased hepatic lipid raft alkaline phosphatase activity observed in a dystrophic mouse model.
Thu Jun 05 00:00:00 EDT 2014
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Molecular and cellular biology
Schneppenheim J,Hüttl S,Mentrup T,Lüllmann-Rauch R,Rothaug M,Engelke M,Dittmann K,Dressel R,Araki M,Araki K,Wienands J,Fluhrer R,Saftig P,Schröder B
13-6800 was used in western blot to test if pharmacological modulation of SPPL2a can deplete B cells.
Tue Apr 01 00:00:00 EDT 2014
Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.
Experimental dermatology
Baumann T,Bergmann S,Schmidt-Rose T,Max H,Martin A,Enthaler B,Terstegen L,Schweiger D,Kalbacher H,Wenck H,Jedlitschky G,Jovanovic Z
13-6800 was used in immunocytochemistry to identify the substrates for ABCC11 and gamma-glutamyl transferase 1 in the apocrine sweat gland
Tue Apr 01 00:00:00 EDT 2014
Impaired renal function and development in Belgrade rats.
American journal of physiology. Renal physiology
Veuthey T,Hoffmann D,Vaidya VS,Wessling-Resnick M
13-6800 was used in western blot to describe the renal physiology of Belgrade rats.
Sat Feb 01 00:00:00 EST 2014
Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.
Molecular pharmacology
Aida K,Hayashi H,Inamura K,Mizuno T,Sugiyama Y
13-6800 was used in western blot to test if ubiquitination regulates the internalization and degradation of bile salt export pump and multidrug resistance-associated protein 2.
Sat Mar 01 00:00:00 EST 2014
Iron increases APP translation and amyloid-beta production in the retina.
Experimental eye research
Guo LY,Alekseev O,Li Y,Song Y,Dunaief JL
13-6800 was used in immunohistochemistry and western blot to examine the importance of iron in relation to amyloid-beta production within the retina
Mon Dec 01 00:00:00 EST 2014
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Molecular biology of the cell
Gallo LI,Liao Y,Ruiz WG,Clayton DR,Li M,Liu YJ,Jiang Y,Fukuda M,Apodaca G,Yin XM
13-6800 was used in Immunocytochemistry to show that TBC1D9B is a Rab11a GTPase-activating proteins that regulates basolateral-to-apical transcytosis in polarised MDCK cells.
Sat Nov 15 00:00:00 EST 2014
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Journal of biochemistry
Satoh D,Hirose T,Harita Y,Daimon C,Harada T,Kurihara H,Yamashita A,Ohno S
13-6800 was used in western blot to study the turnover of intact cell-surface slit diaphragm components.
Fri Aug 01 00:00:00 EDT 2014
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Methods in enzymology
Matsui T,Fukuda M
13-6800 was used in immunocytochemistry and western blot to elucidate the mechanism of TfR degradation.
Thu Jul 31 00:00:00 EDT 2014
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Methods in enzymology
Matsui T,Fukuda M
13-6800 was used in immunocytochemistry and western blot to elucidate the mechanism of TfR degradation.
Thu Jul 31 00:00:00 EDT 2014
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Methods in enzymology
Matsui T,Fukuda M
13-6800 was used in immunocytochemistry and western blot to elucidate the mechanism of TfR degradation.
Thu Jul 31 00:00:00 EDT 2014
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
PloS one
de Carvalho JV,de Castro RO,da Silva EZ,Silveira PP,da Silva-Januário ME,Arruda E,Jamur MC,Oliver C,Aguiar RS,daSilva LL
13-6800 was used in immunocytochemistry to test if Nef modifies the composition of exosomes released by T lymphocytes
Tue Aug 04 00:00:00 EDT 2015
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.
The Journal of biological chemistry
Poirier S,Samami S,Mamarbachi M,Demers A,Chang TY,Vance DE,Hatch GM,Mayer G
Fri Jul 04 00:00:00 EDT 2014
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
The Journal of biological chemistry
DeBosch BJ,Chen Z,Saben JL,Finck BN,Moley KH
13-6890 was used in immunocytochemistry to study the role of glucose transporter 8 in de novo lipogenesis and macrosteatosis
Fri Apr 18 00:00:00 EDT 2014
Phagolysosomal Trafficking Assay.
Bio-protocol
Mehra A
13-6800 was used in Immunocytochemistry-immunoflourescence to develop a protocol for the infection of macrophages with mycobacterial species followed by indirect-immunofluorescence microscopy to visualise host vacuolar markers.
Sat Jul 05 00:00:00 EDT 2014
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
The Journal of biological chemistry
Moroishi T,Yamauchi T,Nishiyama M,Nakayama KI
13-6800 was used in western blot to study the role of HERC2 in FBXL5 degradation and iron metabolism
Fri Jun 06 00:00:00 EDT 2014
A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
The Journal of biological chemistry
Landry MC,Champagne C,Boulanger MC,Jetté A,Fuchs M,Dziengelewski C,Lavoie JN
13-6890 was used in western blot to unravel the functional relation between mitochondria-shaping proteins and the small GTPase Rab11a
Fri Jan 24 00:00:00 EST 2014
Arf4 is required for Mammalian development but dispensable for ciliary assembly.
PLoS genetics
Follit JA,San Agustin JT,Jonassen JA,Huang T,Rivera-Perez JA,Tremblay KD,Pazour GJ
13-6800 was used in immunocytochemistry to elucidate the role of Arf4 in ciliary protein trafficking.
Sat Feb 01 00:00:00 EST 2014
A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.
Nature cell biology
Steinberg F,Gallon M,Winfield M,Thomas EC,Bell AJ,Heesom KJ,Tavaré JM,Cullen PJ
13-6890 was used in western blot to report a unbiased global view of SNX27-mediated sorting.
Wed May 01 00:00:00 EDT 2013
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Neuron
Das U,Scott DA,Ganguly A,Koo EH,Tang Y,Roy S
13-6800 was used in western blot to investigate the convergence of APP and BACE-.
Wed Aug 07 00:00:00 EDT 2013
Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Larson CL,Beare PA,Howe D,Heinzen RA
13-6800 was used in Immunocytochemistry-immunoflourescence to reveal the importance of clathrin-coated vesicle trafficking in Coxiella burnetii infection and a role for Coxiella vacuolar protein A in subverting transport mechanisms.
Tue Dec 03 00:00:00 EST 2013
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xu W,Tse YC,Dobie FA,Baudry M,Craig AM,Wong TP,Wang YT
13-6890 was used in immunocytochemistry and western blot to examine the biotinylation of vesicular transporters as a tool for the study of presynaptic function.
Wed Mar 27 00:00:00 EDT 2013
Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gabriel LR,Wu S,Kearney P,Bellvé KD,Standley C,Fogarty KE,Melikian HE
13-6800 was used in western blot to test if constitutive and PKC-stimulated DAT internalization are dynamin-dependent in adult dopaminergic neurons.
Wed Nov 06 00:00:00 EST 2013
The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Duman JG,Tzeng CP,Tu YK,Munjal T,Schwechter B,Ho TS,Tolias KF
13-6800 was used in immunocytochemistry to determine the role of BAI1 in synaptogenesis.
Wed Apr 17 00:00:00 EDT 2013
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Martineau M,Shi T,Puyal J,Knolhoff AM,Dulong J,Gasnier B,Klingauf J,Sweedler JV,Jahn R,Mothet JP
13-6800 was used in western blot to elucidate the release of gliotransmitters.
Wed Feb 20 00:00:00 EST 2013
Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes.
Journal of lipid research
Morita SY,Tsuda T,Horikami M,Teraoka R,Kitagawa S,Terada T
13-6800 was used in Western Blotting to investigate the relationship between the function of ABCB4 and lipid rafts.
Wed May 01 00:00:00 EDT 2013
Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis.
Molecular cancer research : MCR
Ahn J,Truesdell P,Meens J,Kadish C,Yang X,Boag AH,Craig AW
13-6800 was used in western blot to determine the role of Fer protein-tyrosine kinase in non-small cell lung cancer tumor progression.
Thu Aug 01 00:00:00 EDT 2013
Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.
The American journal of pathology
Huang ML,Sivagurunathan S,Ting S,Jansson PJ,Austin CJ,Kelly M,Semsarian C,Zhang D,Richardson DR
13-6890 was used in western blot to study the pathogenesis of cardiomyopathy in Friedreich ataxia
Sun Sep 01 00:00:00 EDT 2013
Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells.
Experimental neurology
Garrido-Gil P,Rodriguez-Pallares J,Dominguez-Meijide A,Guerra MJ,Labandeira-Garcia JL
13-6800 was used in immunocytochemistry and western blot to test if angiotensin affects iron homeostasis.
Sun Dec 01 00:00:00 EST 2013
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.
Journal of immunology (Baltimore, Md. : 1950)
Snodgrass RG,Huang S,Choi IW,Rutledge JC,Hwang DH
13-6890 was used in Western Blotting to provide evidence that palmitic acid directly activates TLR2 by inducing heterodimerization with TLR1 in an NADPH oxidase-dependent manner.
Tue Oct 15 00:00:00 EDT 2013
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.
Carcinogenesis
Sak MM,Szymanska M,Bertelsen V,Hasmann M,Madshus IH,Stang E
13-6800 was used in western blot to investigate factors that regulate ErbB2-ErbB3 heterodimerization.
Sun Sep 01 00:00:00 EDT 2013
Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cells.
Pflugers Archiv : European journal of physiology
Matsuoka H,Harada K,Nakamura J,Inoue M
13-6800 was used in western blot to investigate how the expression and localization of TASK channels are regulated in rat adrenal medullary cells and PC2 cells.
Mon Jul 01 00:00:00 EDT 2013
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.
Molecular pharmacology
Lui GY,Obeidy P,Ford SJ,Tselepis C,Sharp DM,Jansson PJ,Kalinowski DS,Kovacevic Z,Lovejoy DB,Richardson DR
13-6800 was used in western blot to examine the in vitro and in vivo activity of deferasirox against cells from human solid tumors.
Tue Jan 01 00:00:00 EST 2013
Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps.
Molecular biology of the cell
Holloway ZG,Velayos-Baeza A,Howell GJ,Levecque C,Ponnambalam S,Sztul E,Monaco AP
13-6800 was used in immunocytochemistry to elucidate mechanisms that regulate ATP7A trafficking
Sat Jun 01 00:00:00 EDT 2013
Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.
Biochemistry
Viswanathan J,Haapasalo A,Kurkinen KM,Natunen T,Mäkinen P,Bertram L,Soininen H,Tanzi RE,Hiltunen M
13-6800 was used in western blot to study the ability of a variant of ubiquilin- to increase gamma-secretase-mediated cleavage of APP at the epsilon site.
Tue Jun 04 00:00:00 EDT 2013
Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex.
Veterinary journal (London, England : 1997)
Poncelet L,Springinsfeld M,Ando K,Héraud C,Kabova A,Brion JP
13-6800 was used in immunohistochemistry to investigate the expression of the transferrin receptor 1, proliferating cell nuclear antigen, p27, and calbindin in feline panleukopenia virus negative kittens.
Sat Jun 01 00:00:00 EDT 2013
Immunocytochemical and biochemical detection of the urokinase-type plasminogen activator receptor (uPAR) in the rat tooth germ and in lipid rafts of PMA-stimulated dental epithelial cells.
Histochemistry and cell biology
von Germar A,Barth K,Schwab W
13-6800 was used in western blot to determine the occurrence and distribution pattern of uPAR in the rat molar tooth germ.
Sun Dec 01 00:00:00 EST 2013
Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources.
Protein engineering, design & selection : PEDS
Tillotson BJ,de Larrinoa IF,Skinner CA,Klavas DM,Shusta EV
13-6800 was used in western blot to use cell lysates and yeast surface display to optimize antibodies to membrane proteins.
Fri Feb 01 00:00:00 EST 2013
A novel actin cytoskeleton-dependent noncaveolar microdomain composed of homo-oligomeric caveolin-2 for activation of insulin signaling.
Biochimica et biophysica acta
Kwon H,Lee J,Jeong K,Jang D,Pak Y
13-6800 was used in immunocytochemistry to investigate the role of caveolin-2 on insulin signaling.
Tue Oct 01 00:00:00 EDT 2013
Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome.
Circulation. Cardiovascular genetics
Boczek NJ,Best JM,Tester DJ,Giudicessi JR,Middha S,Evans JM,Kamp TJ,Ackerman MJ
13-6800 was used in western blot to discuss genes that are involved in Long QT syndrome.
Sat Jun 01 00:00:00 EDT 2013
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
The Journal of biological chemistry
Dettmer U,Newman AJ,Luth ES,Bartels T,Selkoe D
13-6800 was used in western blot to study the existance of alpha- and beta-synuclein predomonantly as oligomers in normal neuronal and non-neuronal cells
Fri Mar 01 00:00:00 EST 2013
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.
Biochimica et biophysica acta
Lane DJ,Chikhani S,Richardson V,Richardson DR
13-6800 was used in western blot to determine the role of ascorbate in transferrin iron uptake.
Sat Jun 01 00:00:00 EDT 2013
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.
PloS one
Kota KP,Eaton B,Lane D,Ulrich M,Ulrich R,Peyser BD,Robinson CG,Jaissle JG,Pegoraro G,Bavari S,Panchal RG
13-6890 was used in western blot to develop an automated high-content imaging assays to quantitate the internalization of Y. pestis and study the activation of NF-kappaB signaling
Fri Jul 19 00:00:00 EDT 2013
Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.
PloS one
Byrne SL,Buckett PD,Kim J,Luo F,Sanford J,Chen J,Enns C,Wessling-Resnick M
13-6800 was used in western blot to report that ferristatin II degrades transferrin receptor-1 through a nystatin-sensitive lipid raft pathway.
Thu Mar 27 00:00:00 EDT 2014
Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.
PloS one
Bol GM,Raman V,van der Groep P,Vermeulen JF,Patel AH,van der Wall E,van Diest PJ
13-6800 was used in immunohistochemistry - paraffin section to examine the relationship between DDX3 and the hypoxic responsive proteins in human breast cancer.
Mon Dec 23 00:00:00 EST 2013
A role for cargo in Arf-dependent adaptor recruitment.
The Journal of biological chemistry
Caster AH,Sztul E,Kahn RA
13-6800 was used in immunocytochemistry to elucidate signals that initiates carrier biogenesis in cells.
Fri May 24 00:00:00 EDT 2013
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Blanc L,Ciciotte SL,Gwynn B,Hildick-Smith GJ,Pierce EL,Soltis KA,Cooney JD,Paw BH,Peters LL
Tue Jul 24 00:00:00 EDT 2012
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Blanc L,Ciciotte SL,Gwynn B,Hildick-Smith GJ,Pierce EL,Soltis KA,Cooney JD,Paw BH,Peters LL
Tue Jul 24 00:00:00 EDT 2012
Cullin-3 regulates late endosome maturation.
Proceedings of the National Academy of Sciences of the United States of America
Huotari J,Meyer-Schaller N,Hubner M,Stauffer S,Katheder N,Horvath P,Mancini R,Helenius A,Peter M
Tue Jan 17 00:00:00 EST 2012
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Cellular and molecular life sciences : CMLS
Prox J,Willenbrock M,Weber S,Lehmann T,Schmidt-Arras D,Schwanbeck R,Saftig P,Schwake M
13-6800 was used in western blot to investigate mechanisms that regulate of ADAM10.
Sat Sep 01 00:00:00 EDT 2012
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gleichman AJ,Spruce LA,Dalmau J,Seeholzer SH,Lynch DR
13-6800 was used in western blot to elucidate the antigenic region of the NMDA receptor.
Wed Aug 08 00:00:00 EDT 2012
GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Journal of virology
Chen Z,Kolokoltsov AA,Wang J,Adhikary S,Lorinczi M,Elferink LA,Davey RA
13-6800 was used in western blot to test if GRB2 contributes to controlling infection by retroviruses by affecting receptor function.
Wed Feb 01 00:00:00 EST 2012
Arenavirus infection induces discrete cytosolic structures for RNA replication.
Journal of virology
Baird NL,York J,Nunberg JH
13-6800 was used in western blot to identify and study cytosolic structures involved in arenavirus replication and transcription.
Mon Oct 01 00:00:00 EDT 2012
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Journal of virology
Magadán JG,Bonifacino JS
Sun Jan 01 00:00:00 EST 2012
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Journal of virology
Magadán JG,Bonifacino JS
Sun Jan 01 00:00:00 EST 2012
α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.
The American journal of surgical pathology
Raess PW,Paessler ME,Bagg A,Weiss MJ,Choi JK
13-6800 was used in immunohistochemistry (paraffin) to report that AHSP is better than CD71 and CD235a for detecting normal and neoplastic nucleated erythroid precursors.
Mon Oct 01 00:00:00 EDT 2012
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
The American journal of pathology
Weeks A,Okolowsky N,Golbourn B,Ivanchuk S,Smith C,Rutka JT
13-6800 was used in Western Blotting to reveal that ECT2 has a novel role in mesenchymal-amoeboid transition in human astrocytoma cells.
Wed Aug 01 00:00:00 EDT 2012
Activation of P2X7R and downstream effects in bleomycin treated lung epithelial cells.
The international journal of biochemistry & cell biology
Bläsche R,Ebeling G,Perike S,Weinhold K,Kasper M,Barth K
13-6800 was used in western blot to report that the treatment of lung epithelial cells with BLM resulted in elevated intracellular Ca(2+) levels and stimulates PKC-β1.
Thu Mar 01 00:00:00 EST 2012
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.
Journal of cell science
Balaji K,Mooser C,Janson CM,Bliss JM,Hojjat H,Colicelli J
13-6800 was used in western blot to elucidate factors that regulate epidermal growth factor receptor recycling.
Sat Dec 01 00:00:00 EST 2012
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
Molecular and cellular biology
Huang YS,Chiang NY,Hu CH,Hsiao CC,Cheng KF,Tsai WP,Yona S,Stacey M,Gordon S,Chang GW,Lin HH
Sun Apr 01 00:00:00 EDT 2012
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
Molecular and cellular biology
Huang YS,Chiang NY,Hu CH,Hsiao CC,Cheng KF,Tsai WP,Yona S,Stacey M,Gordon S,Chang GW,Lin HH
Sun Apr 01 00:00:00 EDT 2012
Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells.
Journal of natural products
Liu WK,Ling YH,Cheung FW,Che CT
13-6800 was used in immunocytochemistry and western blot to investigate the mechanisms by which stellettin A () inhibits the growth of B6F0 murine melanoma cells.
Fri Apr 27 00:00:00 EDT 2012
Nitric oxide induces segregation of decay accelerating factor (DAF or CD55) from the membrane lipid-rafts and its internalization in human endometrial cells.
Cell biology international
Banadakoppa M,Goluszko P,Liebenthal D,Yallampalli C
13-6800 was used in western blot to assess the role of nitric oxide to E. coli infection.
Mon Oct 01 00:00:00 EDT 2012
Interaction of influenza A virus matrix protein with RACK1 is required for virus release.
Cellular microbiology
Demirov D,Gabriel G,Schneider C,Hohenberg H,Ludwig S
13-6800 was used in Western Blotting to reveal the role of the viral matrix proteins in the release of influenza A virus particles via the RACK1-mediated pathway.
Tue May 01 00:00:00 EDT 2012
Differential expression of potassium channels in placentas from normal and pathological pregnancies: targeting of the K(ir) 2.1 channel to lipid rafts.
The Journal of membrane biology
Riquelme G,de Gregorio N,Vallejos C,Berrios M,Morales B
13-6800 was used in western blot to determine the localization of potassium channels in placental tissue.
Thu Mar 01 00:00:00 EST 2012
Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.
PloS one
Patrushev N,Seidel-Rogol B,Salazar G
13-6800 was used in western blot to explore the role of zinc in vascular dysfunction.
Mon Aug 20 00:00:00 EDT 2012
Anti-melanogenic property of geoditin A in murine B16 melanoma cells.
Marine drugs
Cheung FWK,Guo J,Ling YH,Che CT,Liu WK
13-6800 was used in western blot to investigate the anti-melanogenic properties of geoditin A.
Wed Feb 01 00:00:00 EST 2012
Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.
The Journal of biological chemistry
Hoffmann F,Müller W,Schütz D,Penfold ME,Wong YH,Schulz S,Stumm R
13-6800 was used in ELISA to test if the distinct C-terminal domains of CXCR4 and CXCR7 differently regulate receptor trafficking and stability.
Fri Aug 17 00:00:00 EDT 2012
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
BMC immunology
Hitomi Y,Adachi T,Tsuchiya N,Honda Z,Tokunaga K,Tsubata T
13-6800 was used in immunocytochemistry to study the polymorphism of CD72 associated with susceptibility to human systemic lupus erythematosus.
Wed Dec 26 00:00:00 EST 2012
Mutations in TRPV4 cause an inherited arthropathy of hands and feet.
Nature genetics
Lamandé SR,Yuan Y,Gresshoff IL,Rowley L,Belluoccio D,Kaluarachchi K,Little CB,Botzenhart E,Zerres K,Amor DJ,Cole WG,Savarirayan R,McIntyre P,Bateman JF
13-6800 was used in immunoprecipitation to investigate the relationship between TRPV4 mutation and FDAB.
Sun Oct 02 00:00:00 EDT 2011
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Cell metabolism
Moroishi T,Nishiyama M,Takeda Y,Iwai K,Nakayama KI
13-6800 was used in Western Blotting to uncover a major role for FBXL5 in ensuring an appropriate supply of iron to cells.
Wed Sep 07 00:00:00 EDT 2011
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions.
The EMBO journal
Zilly FE,Halemani ND,Walrafen D,Spitta L,Schreiber A,Jahn R,Lang T
13-6800 was used in Immunocytochemistry to examine the role of Ca(2+) in membrane protein organisation.
Wed Apr 06 00:00:00 EDT 2011
A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.
Developmental cell
Bass MD,Williamson RC,Nunan RD,Humphries JD,Byron A,Morgan MR,Martin P,Humphries MJ
13-6800 was used in western blot to report a role for a syndecan-4-regulated integrin endocytic pathway in wound repair.
Tue Oct 18 00:00:00 EDT 2011
The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB.
PLoS pathogens
Schneider CL,Hudson AW
13-6800 was used in flow cytometry and western blot to report that the human herpesvirus-7 U21 gene product interferes with natural killer cell recognition
Tue Nov 01 00:00:00 EDT 2011
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Feldmann A,Amphornrat J,Schönherr M,Winterstein C,Möbius W,Ruhwedel T,Danglot L,Nave KA,Galli T,Bruns D,Trotter J,Krämer-Albers EM
13-6800 was used in immunocytochemistry to study the role of VAMP3/cellubrevin and VAMP7/TI-VAMP in myelin membrane trafficking.
Wed Apr 13 00:00:00 EDT 2011
Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target.
Thyroid : official journal of the American Thyroid Association
Magro G,Cataldo I,Amico P,Torrisi A,Vecchio GM,Parenti R,Asioli S,Recupero D,D'Agata V,Mucignat MT,Perris R
13-6800 was used in immunohistochemistry - paraffin section and western blot to test if TfR1/CD71 is differentially expressed among benign and malignant thyroid tissues.
Tue Mar 01 00:00:00 EST 2011
Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target.
Thyroid : official journal of the American Thyroid Association
Magro G,Cataldo I,Amico P,Torrisi A,Vecchio GM,Parenti R,Asioli S,Recupero D,D'Agata V,Mucignat MT,Perris R
13-6800 was used in immunohistochemistry - paraffin section and western blot to test if TfR1/CD71 is differentially expressed among benign and malignant thyroid tissues.
Tue Mar 01 00:00:00 EST 2011
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Selvais C,D'Auria L,Tyteca D,Perrot G,Lemoine P,Troeberg L,Dedieu S,Noël A,Nagase H,Henriet P,Courtoy PJ,Marbaix E,Emonard H
13-6800 was used in western blot to elucidate the mechanisms by which cholesterol regulates LRP-1 levels and function at the plasma membrane.
Mon Aug 01 00:00:00 EDT 2011
Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts.
The international journal of biochemistry & cell biology
Linge A,Meleady P,Henry M,Clynes M,Kasper M,Barth K
13-6800 was used in western blot to elucidate the caveolin-1-mediated senescence in bleomycin treatment of A549 cells
Sat Jan 01 00:00:00 EST 2011
The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins.
Molecular pharmaceutics
Bachran D,Schneider S,Bachran C,Weng A,Melzig MF,Fuchs H
13-6800 was used in western blot to elucidate the mechanism of Saponinum album-induced cytotoxicity.
Mon Dec 05 00:00:00 EST 2011
Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.
American journal of physiology. Cell physiology
Best JM,Foell JD,Buss CR,Delisle BP,Balijepalli RC,January CT,Kamp TJ
13-6800 was used in western blot to test if Rab11b affects plasmalemmal expression of Ca(v)1.2.
Sun May 01 00:00:00 EDT 2011
Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin.
American journal of physiology. Cell physiology
Xinhan L,Matsushita M,Numaza M,Taguchi A,Mitsui K,Kanazawa H
13-6800 was used in western blot to study the role of NHE6 in endocytosis.
Thu Dec 01 00:00:00 EST 2011
Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
Human molecular genetics
Bijlmakers MJ,Kanneganti SK,Barker JN,Trembath RC,Capon F
13-6800 was used in western blot to test if RNF114 modulates RIG-I/MDA5 signaling.
Mon Aug 15 00:00:00 EDT 2011
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Molecular and cellular biology
Sarajärvi T,Tuusa JT,Haapasalo A,Lackman JJ,Sormunen R,Helisalmi S,Roehr JT,Parrado AR,Mäkinen P,Bertram L,Soininen H,Tanzi RE,Petäjä-Repo UE,Hiltunen M
13-6800 was used in immunocytochemistry to investigate how the deltaOR-Cys27 variant affects amyloid precursor protein processing and trafficking.
Wed Jun 01 00:00:00 EDT 2011
Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase.
Molecular and cellular biology
Mendes AI,Matos P,Moniz S,Luz S,Amaral MD,Farinha CM,Jordan P
13-6800 was used in western blot to investigate how WNK4 regulates CFTR.
Sat Oct 01 00:00:00 EDT 2011
Transient expression of iron transport proteins in the capillary of the developing rat brain.
Cellular and molecular neurobiology
Yang WM,Jung KJ,Lee MO,Lee YS,Lee YH,Nakagawa S,Niwa M,Cho SS,Kim DW
13-6800 was used in immunohistochemistry - frozen section and western blot to examine the expression of iron transport proteins in the developing rat brain
Sat Jan 01 00:00:00 EST 2011
Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast.
Molecular pharmacology
Errasti-Murugarren E,Díaz P,Godoy V,Riquelme G,Pastor-Anglada M
Tue Nov 01 00:00:00 EDT 2011
Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release.
FEBS letters
Gil C,Falqués A,Sarró E,Cubi R,Blasi J,Aguilera J,Itarte E
13-6800 was used in western blot to investigate the function of protein kinase CK2 in lipid rafts.
Fri Jan 21 00:00:00 EST 2011
MICAL-like1 mediates epidermal growth factor receptor endocytosis.
Molecular biology of the cell
Abou-Zeid N,Pandjaitan R,Sengmanivong L,David V,Le Pavec G,Salamero J,Zahraoui A
Thu Sep 01 00:00:00 EDT 2011
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas.
Placenta
Mandò C,Tabano S,Colapietro P,Pileri P,Colleoni F,Avagliano L,Doi P,Bulfamante G,Miozzo M,Cetin I
13-6800 was used in immunohistochemistry - paraffin section to examine Transferrin Receptor 1 expression in IUGR and control placentas
Sat Jan 01 00:00:00 EST 2011
Transferrin receptor expression in canine lymphoma.
Veterinary pathology
Priest H,McDonough S,Erb H,Daddona J,Stokol T
13-6800 was used in immunohistochemistry - paraffin section and western blot to determine transferrin receptor 1 expression in canine B-cell and T-cell lymphoma
Tue Mar 01 00:00:00 EST 2011
Automated analysis of neuronal morphology, synapse number and synaptic recruitment.
Journal of neuroscience methods
Schmitz SK,Hjorth JJ,Joemai RM,Wijntjes R,Eijgenraam S,de Bruijn P,Georgiou C,de Jong AP,van Ooyen A,Verhage M,Cornelisse LN,Toonen RF,Veldkamp WJ
13-6800 was used in immunocytochemistry to develop a method to automatically assess dendrite morphology, synapse size, number, and other neuronal characteristics.
Tue Feb 15 00:00:00 EST 2011
Acetaldehyde/alcohol dehydrogenase-2 (EhADH2) and clathrin are involved in internalization of human transferrin by Entamoeba histolytica.
Microbiology (Reading, England)
Reyes-López M,Bermúdez-Cruz RM,Avila EE,de la Garza M
13-6800 was used in immunoprecipitation and western blot to investigate how Entamoeba histolytica scavenges iron
Sat Jan 01 00:00:00 EST 2011
Lipid rafts and cytoskeletal proteins in placental microvilli membranes from preeclamptic and IUGR pregnancies.
The Journal of membrane biology
Riquelme G,Vallejos C,de Gregorio N,Morales B,Godoy V,Berrios M,Bastías N,Rodríguez C
13-6800 was used in western blot to examine the raft and cytoskeletal proteins from intrauterine growth restriction and preeclampsia.
Wed Jun 01 00:00:00 EDT 2011
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
The Journal of biological chemistry
Takatsu H,Baba K,Shima T,Umino H,Kato U,Umeda M,Nakayama K,Shin HW
13-6800 was used in western blot to study the subcellular localization of human P4-ATPases and their interactions with CDC50 proteins.
Fri Nov 04 00:00:00 EDT 2011
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
The Journal of biological chemistry
Chiang NY,Hsiao CC,Huang YS,Chen HY,Hsieh IJ,Chang GW,Lin HH
13-6800 was used in western blot to elucidate the cellular functions of GPR56 receptor and how they contribute to bilateral frontoparietal polymicrogyria.
Fri Apr 22 00:00:00 EDT 2011
Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.
The Journal of biological chemistry
Yu Y,Richardson DR
13-6800 was used in western blot to identify signaling pathways affected by iron depletion induced by desferrioxamine or di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone.
Fri Apr 29 00:00:00 EDT 2011
Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency.
Experimental biology and medicine (Maywood, N.J.)
Mostad EJ,Prohaska JR
13-6800 was used in western blot to test if dietary copper-deficient rodents have lower levels of glycosylphosphatidylinositol-anchored ceruloplasmin and if this correlates with higher tissue iron retention.
Tue Mar 01 00:00:00 EST 2011
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PloS one
Breuer S,Schievink SI,Schulte A,Blankenfeldt W,Fackler OT,Geyer M
13-6800 was used in flow cytometry to study Nef inhibitors as a means to control HIV infection.
Mon Oct 17 00:00:00 EDT 2011
Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal.
Blood
Skorokhod OA,Caione L,Marrocco T,Migliardi G,Barrera V,Arese P,Piacibello W,Schwarzer E
13-6800 was used in western blot to identify 4-hydroxynonenal as a hemozoin-generated inhibitory molecule and describe molecular targets of 4-hydroxynonena in erythroid progenitors
Thu Nov 18 00:00:00 EST 2010
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.
Blood
Barrès C,Blanc L,Bette-Bobillo P,André S,Mamoun R,Gabius HJ,Vidal M
13-6800 was used in western blot to examine the role of galectin-5 in the exosomal sorting pathway during rat reticulocyte maturation
Thu Jan 21 00:00:00 EST 2010
Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.
Proceedings of the National Academy of Sciences of the United States of America
Nitta T,Kuznetsov Y,McPherson A,Fan H
13-6800 was used in immunocytochemistry to report that gPr80gag facilitates the release of Moloney murine leukemia virus
Tue Jan 19 00:00:00 EST 2010
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
The Journal of cell biology
Ludwig A,Otto GP,Riento K,Hams E,Fallon PG,Nichols BJ
13-6800 was used in western blot to investigate the role of flotillin 1 in neutrophil chemotaxis.
Mon Nov 15 00:00:00 EST 2010
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Khirug S,Ahmad F,Puskarjov M,Afzalov R,Kaila K,Blaesse P
13-6800 was used in western blot to assess the role of KCC2 in neonatal seizure episodes induced by kainate injection
Wed Sep 08 00:00:00 EDT 2010
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Newell-Litwa K,Chintala S,Jenkins S,Pare JF,McGaha L,Smith Y,Faundez V
13-6800 was used in western blot to examine AP-3-dependent synaptic vesicle biogenesis
Wed Jan 20 00:00:00 EST 2010
Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
Archives of toxicology
Mizukami S,Ichimura R,Kemmochi S,Taniai E,Shimamoto K,Ohishi T,Takahashi M,Mitsumori K,Shibutani M
13-6800 was used in immunohistochemistry - paraffin section to determine the role of metal-related molecules in hepatocarcinogenesis
Thu Apr 01 00:00:00 EDT 2010
Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein.
Journal of neurochemistry
Kerr ML,Gasperini R,Gibbs ME,Hou X,Shepherd CE,Strickland DK,Foa L,Lawen A,Small DH
13-6800 was used in immunoprecipitation to report that RAP binds to and inhibits Abeta.
Mon Mar 01 00:00:00 EST 2010
CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens.
American journal of clinical pathology
Marsee DK,Pinkus GS,Yu H
13-6800 was used in immunohistochemistry - paraffin section to define the immunohistochemical profile of CD71
Wed Sep 01 00:00:00 EDT 2010
Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles.
Proteomics
Steuble M,Gerrits B,Ludwig A,Mateos JM,Diep TM,Tagaya M,Stephan A,Schätzle P,Kunz B,Streit P,Sonderegger P
Mon Nov 01 00:00:00 EDT 2010
Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
Chemico-biological interactions
Mizukami S,Ichimura R,Kemmochi S,Wang L,Taniai E,Mitsumori K,Shibutani M
13-6800 was used in immunohistochemistry - paraffin section to study liver tumor promotion mechanisms of copper- and iron-overloading
Fri May 14 00:00:00 EDT 2010
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity.
Cellular microbiology
Rolando M,Stefani C,Flatau G,Auberger P,Mettouchi A,Mhlanga M,Rapp U,Galmiche A,Lemichez E
13-6800 was used in western blot to study how Bacillus anthracis lethal toxin promotes caspase-3 activation and the formation of thick actin cables in human endothelial cells
Thu Jul 01 00:00:00 EDT 2010
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.
Molecular biology of the cell
Yamamoto H,Koga H,Katoh Y,Takahashi S,Nakayama K,Shin HW
13-6800 was used in immunocytochemistry to show that Rab14 binds in a GTP-dependent manner to RUFY1/Rabip4
Sun Aug 01 00:00:00 EDT 2010
A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes.
The Journal of membrane biology
Fukura N,Ohgaki R,Matsushita M,Nakamura N,Mitsui K,Kanazawa H
13-6800 was used in immunocytochemistry to identify the intramolecular region involved in the specific localization of NHE6 and NHE7
Thu Apr 01 00:00:00 EDT 2010
Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources.
Protein engineering, design & selection : PEDS
Cho YK,Shusta EV
13-6800 was used in flow cytometry to perform high-throughput antibody screening using detergent-solubilized and biotinylated whole-cell lysates as the antigen source
Thu Jul 01 00:00:00 EDT 2010
Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity.
Lipids
McIntosh AL,Storey SM,Atshaves BP
13-6800 was used in western blot to investigate the efflux of sphingomyelin from lipid droplets
Tue Jun 01 00:00:00 EDT 2010
Cloning and tissue expression of the equine transferrin receptor.
Veterinary clinical pathology
Webb TL,Burnett RC,Avery AC,Olver CS
13-6800 was used in immunohistochemistry - paraffin section to test if equine TfR expression correlates with a regenerative response in anemic horses
Wed Dec 01 00:00:00 EST 2010
T1alpha/podoplanin shows raft-associated distribution in mouse lung alveolar epithelial E10 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Barth K,Bläsche R,Kasper M
13-6800 was used in Western Blotting to study the characteristics of raft domains in the microplicae/microvillar protrusions of alveolar epithelial type I cells, which contain T1alpha.
Thu Feb 25 00:00:00 EST 2010
Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).
Biochimica et biophysica acta
Kato T,Hayashi H,Sugiyama Y
13-6800 was used in western blot to search for compounds to treat intrahepatic cholestasis
Wed Sep 01 00:00:00 EDT 2010
ZF21 protein regulates cell adhesion and motility.
The Journal of biological chemistry
Nagano M,Hoshino D,Sakamoto T,Kawasaki N,Koshikawa N,Seiki M
13-6800 was used in western blot to identify ZF21 as a regulator of focal adhesion and cell movement
Fri Jul 02 00:00:00 EDT 2010
Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.
Marine drugs
Cheung FW,Li C,Che CT,Liu BP,Wang L,Liu WK
13-6800 was used in western blot to study Geoditin A-induced apoptosis
Tue Jan 19 00:00:00 EST 2010
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Nature
Ishikawa H,Ma Z,Barber GN
13-6800 was used in ELISA to report that STING is needed for the induction of IFN by non-CpG intracellular DNA pathogens.
Thu Oct 08 00:00:00 EDT 2009
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.
Developmental cell
Wu L,Derynck R
13-6800 was used in western blot to investigate TGF-beta signaling in glucose-induced cell hypertrophy of fibroblasts and epithelial cells
Wed Jul 01 00:00:00 EDT 2009
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Science signaling
Humphries JD,Byron A,Bass MD,Craig SE,Pinney JW,Knight D,Humphries MJ
13-6800 was used in western blot to report a method to isolate complexes associated with integrin adhesion receptors
Tue Sep 08 00:00:00 EDT 2009
Differential effects of EGFR ligands on endocytic sorting of the receptor.
Traffic (Copenhagen, Denmark)
Roepstorff K,Grandal MV,Henriksen L,Knudsen SL,Lerdrup M,Grøvdal L,Willumsen BM,van Deurs B
13-6800 was used in western blot to investigate the effect of EGFR ligands on receptor internalization and endocytic sorting
Sat Aug 01 00:00:00 EDT 2009
Exosomal sorting of the cytoplasmic domain of bovine leukemia virus TM Env protein.
Cell biology international
De Gassart A,Trentin B,Martin M,Hocquellet A,Bette-Bobillo P,Mamoun R,Vidal M
13-6800 was used in western blot to elucidate the molecular basis of protein sorting into exosomes
Thu Jan 01 00:00:00 EST 2009
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
Journal of neuroscience research
Feldmann A,Winterstein C,White R,Trotter J,Krämer-Albers EM
13-6800 was used in western blot to characterize oligodendroglial SNAREs and their trafficking pathways
Mon Jun 01 00:00:00 EDT 2009
Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors.
Toxicology letters
Youn P,Kim S,Ahn JH,Kim Y,Park JD,Ryu DY
13-6800 was used in western blot to examine iron metabolism in liver tumors
Tue Feb 10 00:00:00 EST 2009
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Infection and immunity
Rhee KJ,Wu S,Wu X,Huso DL,Karim B,Franco AA,Rabizadeh S,Golub JE,Mathews LE,Shin J,Sartor RB,Golenbock D,Hamad AR,Gan CM,Housseau F,Sears CL
13-6800 was used in western blot to develop and characterize a murine model to study enterotoxigenic Bacteroides fragilis infection
Wed Apr 01 00:00:00 EDT 2009
Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice.
In vitro cellular & developmental biology. Animal
Duan W,Zhang R,Guo Y,Jiang Y,Huang Y,Jiang H,Li C
13-6800 was used in western blot to study aging and the loss of antioxidant tolerance capacity
Tue Nov 17 00:00:00 EST 2009
Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells.
PloS one
Skinner AM,O'Neill SL,Kurre P
13-6800 was used in immunocytochemistry to test if existing microvesicle pathways transfer RNA genomes horizontally between cells
Mon Jul 13 00:00:00 EDT 2009
SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.
PloS one
Salazar G,Falcon-Perez JM,Harrison R,Faundez V
13-6800 was used in western blot to investigate oligomerization of solute carrier family 30 member 3/zinc transporter 3
Fri Jun 12 00:00:00 EDT 2009
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
The Journal of biological chemistry
Sarajärvi T,Haapasalo A,Viswanathan J,Mäkinen P,Laitinen M,Soininen H,Hiltunen M
13-6800 was used in immunocytochemistry to examine the effects of seladin-1 down-regulation on the beta-secretase function and beta-amyloid precursor protein processing
Fri Dec 04 00:00:00 EST 2009
An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma.
Cancer research
Kongkham PN,Northcott PA,Ra YS,Nakahara Y,Mainprize TG,Croul SE,Smith CA,Taylor MD,Rutka JT
13-6800 was used in western blot to identify tumor suppressor genes involved in medulloblastoma pathogenesis
Mon Dec 01 00:00:00 EST 2008
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Cell death and differentiation
Lespagnol A,Duflaut D,Beekman C,Blanc L,Fiucci G,Marine JC,Vidal M,Amson R,Telerman A
13-6800 was used in flow cytometry, immunocytochemistry, and western blot to elucidate the physiological function of TSAP6
Sat Nov 01 00:00:00 EDT 2008
Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover.
Oncogene
Koch A,Scherr M,Breyer B,Mancini A,Kardinal C,Battmer K,Eder M,Tamura T
13-6800 was used in western blot to elucidate how nerve growth factor signaling affects chronic myelogenous leukemia cell lines
Thu Aug 07 00:00:00 EDT 2008
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Neurobiology of disease
Parisiadou L,Bethani I,Michaki V,Krousti K,Rapti G,Efthimiopoulos S
13-6800 was used in western blot to investigate the consequences of Homer proteins interacting with the amyloid precursor protein
Sun Jun 01 00:00:00 EDT 2008
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kolodziej A,Schulz S,Guyon A,Wu DF,Pfeiffer M,Odemis V,Höllt V,Stumm R
13-6800 was used in western blot to elucidate the regulation and function of CXCR4 in the rat postnatal dentate gyrus
Wed Apr 23 00:00:00 EDT 2008
Dynamics of somatostatin type 2A receptor cargoes in living hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lelouvier B,Tamagno G,Kaindl AM,Roland A,Lelievre V,Le Verche V,Loudes C,Gressens P,Faivre-Baumann A,Lenkei Z,Dournaud P
13-6800 was used in immunocytochemistry to investigate the functions of somatostatin type 2A receptor in neurons
Wed Apr 23 00:00:00 EDT 2008
New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1.
Journal of virology
Flanagan ML,Oldenburg J,Reignier T,Holt N,Hamilton GA,Martin VK,Cannon PM
13-6800 was used in western blot to investigate the use of TfR1 by the glycoproteins from a panel of New World clade B arenaviruses
Tue Jan 01 00:00:00 EST 2008
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
Journal of virology
Rauch S,Pulkkinen K,Saksela K,Fackler OT
13-6800 was used in western blot to identify which guanine nucleotide exchange factors mediate the functional interaction of HIV-1 Nef with p21-activate kinase 2 activity
Sat Mar 01 00:00:00 EST 2008
Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yan HH,Mruk DD,Lee WM,Cheng CY
Sun Jun 01 00:00:00 EDT 2008
Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells.
The international journal of biochemistry & cell biology
Barth K,Weinhold K,Guenther A,Linge A,Gereke M,Kasper M
13-6800 was used in western blot to investigate the expression, localization, and interactions of the P2X(4)R
Thu Oct 02 00:00:00 EDT 2008
Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?
Laboratory investigation; a journal of technical methods and pathology
Bergmann OM,Mathahs MM,Broadhurst KA,Weydert JA,Wilkinson N,Howe JR,Han O,Schmidt WN,Brown KE
13-6800 was used in western blot to compare the expression of genes involved in the regulation of iron metabolism in cirrhotic and control human livers
Mon Dec 01 00:00:00 EST 2008
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
Journal of immunology (Baltimore, Md. : 1950)
Witte V,Laffert B,Gintschel P,Krautkrämer E,Blume K,Fackler OT,Baur AS
13-6800 was used in western blot to elucidate Nef-mediated signaling
Mon Dec 15 00:00:00 EST 2008
Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
Carcinogenesis
Takahashi M,Shibutani M,Woo GH,Inoue K,Fujimoto H,Igarashi K,Kanno J,Hirose M,Nishikawa A
13-6800 was used in immunohistochemistry - paraffin section to identify factors that are altered during rat hepatocarcinogenesis
Sat Nov 01 00:00:00 EDT 2008
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
Neuroscience
Roberts LM,Black DS,Raman C,Woodford K,Zhou M,Haggerty JE,Yan AT,Cwirla SE,Grindstaff KK
13-6800 was used in western blot to study the luminal/abluminal localization of a number of blood-brain barrier transporters expressed by endothelial cells
Wed Aug 13 00:00:00 EDT 2008
Receptor use by the Whitewater Arroyo virus glycoprotein.
Virology
Reignier T,Oldenburg J,Flanagan ML,Hamilton GA,Martin VK,Cannon PM
13-6800 was used in western blot to determine if Whitewater Arroyo virus glycoprotein uses hTfR1 for entry, and compare its tropism to glycoproteins from non-pathogenic New World clade B arenaviruses
Wed Feb 20 00:00:00 EST 2008
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
Biochemical and biophysical research communications
Kamemura K,Ito A,Shimazu T,Matsuyama A,Maeda S,Yao TP,Horinouchi S,Khochbin S,Yoshida M
13-6800 was used in western blot to examine the effect of histone deacetylase 6 reduction on lung cancer cells
Fri Sep 12 00:00:00 EDT 2008
Human RME-8 is involved in membrane trafficking through early endosomes.
Cell structure and function
Fujibayashi A,Taguchi T,Misaki R,Ohtani M,Dohmae N,Takio K,Yamada M,Gu J,Yamakami M,Fukuda M,Waguri S,Uchiyama Y,Yoshimori T,Sekiguchi K
13-6800 was used in immunocytochemistry to study the biochemical properties and functions of human RME-8 (hRME-8) in endocytic pathways
Wed Jun 04 00:00:00 EDT 2008
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.
The Journal of biological chemistry
Zhang L,Lee JE,Wilusz J,Wilusz CJ
13-6800 was used in western blot to elucidate how Type I myotonic dystrophy results in increased tumor necrosis factor
Fri Aug 15 00:00:00 EDT 2008
Cholesterol substitution increases the structural heterogeneity of caveolae.
The Journal of biological chemistry
Jansen M,Pietiaïnen VM,Pölönen H,Rasilainen L,Koivusalo M,Ruotsalainen U,Jokitalo E,Ikonen E
13-6800 was used in western blot to explore the importance of sterol specificity for the structure and function of caveolae
Fri May 23 00:00:00 EDT 2008
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
The Journal of biological chemistry
Lineberry N,Su L,Soares L,Fathman CG
13-6800 was used in western blot to screen for proteins that bound the protease-associated domain of GRAIL
Fri Oct 17 00:00:00 EDT 2008
Cell-surface biotinylation to study endocytosis and recycling of occludin.
Methods in molecular biology (Clifton, N.J.)
Nishimura N,Sasaki T
13-6800 was used in western blot to explore the intracellular transport of occludin in fibroblastic and epithelial cells
Thu May 15 00:00:00 EDT 2008
TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
The Journal of biological chemistry
van de Graaf SF,Rescher U,Hoenderop JG,Verkaart S,Bindels RJ,Gerke V
13-6800 was used in western blot to find that the epithelial Ca(2+) channel TRPV5 is constitutively internalized in a dynamin- and clathrin-dependent manner and constitutively recycles back to the surface
Fri Feb 15 00:00:00 EST 2008
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
The Journal of biological chemistry
Grimsey N,Han GS,O'Hara L,Rochford JJ,Carman GM,Siniossoglou S
13-6800 was used in western blot to study distinct and non-redundant functions of lipin 1 and 2
Fri Oct 24 00:00:00 EDT 2008
Cytoskeletal involvement in the cellular trafficking of plasmid/PEI derivative complexes.
Journal of controlled release : official journal of the Controlled Release Society
Grosse S,Aron Y,Thévenot G,Monsigny M,Fajac I
13-6800 was used in immunocytochemistry to examine major cytoskeletal elements involved in cellular trafficking of complexes made with PEI derivatives
Tue Sep 11 00:00:00 EDT 2007
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
The Journal of investigative dermatology
Gaggioli C,Robert G,Bertolotto C,Bailet O,Abbe P,Spadafora A,Bahadoran P,Ortonne JP,Baron V,Ballotti R,Tartare-Deckert S
13-6800 was used in western blot to investigate the link between the ERK/MAP kinase pathway and fibronectin in melanoma
Thu Feb 01 00:00:00 EST 2007
Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex.
Journal of neurochemistry
Li X,Serwanski DR,Miralles CP,Bahr BA,De Blas AL
13-6800 was used in western blot to study GABA(A)Rs association with lipid rafts isolated from rat forebrain synaptosomes.
Wed Aug 01 00:00:00 EDT 2007
Rab11-FIP2 regulates differentiable steps in transcytosis.
American journal of physiology. Cell physiology
Ducharme NA,Williams JA,Oztan A,Apodaca G,Lapierre LA,Goldenring JR
13-6800 was used in immunocytochemistry to describe a point mutant in Rab11 family interacting protein 2 that alters the function of Rab11a-containing trafficking systems
Sat Sep 01 00:00:00 EDT 2007
Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha.
Neurobiology of aging
Parisiadou L,Efthimiopoulos S
13-6800 was used in western blot to study the effect of mDab1 on amyloid precursor protein processing
Thu Mar 01 00:00:00 EST 2007
Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes.
Endocrinology
Balbis A,Parmar A,Wang Y,Baquiran G,Posner BI
13-6800 was used in western blot to study the effect of physiological doses of epidermal growth factor on the compartmentalization and activation of its receptor.
Fri Jun 01 00:00:00 EDT 2007
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
Journal of cellular biochemistry
Abache T,Le Naour F,Planchon S,Harper F,Boucheix C,Rubinstein E
13-6800 was used in immunocytochemistry and western blot to demonstrate that treatment of K562 cells with the phorbol ester TPA induces the down-modulation of various surface antigens
Mon Oct 15 00:00:00 EDT 2007
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
Journal of cellular biochemistry
Abache T,Le Naour F,Planchon S,Harper F,Boucheix C,Rubinstein E
13-6800 was used in immunocytochemistry and western blot to demonstrate that treatment of K562 cells with the phorbol ester TPA induces the down-modulation of various surface antigens
Mon Oct 15 00:00:00 EDT 2007
Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro.
The Journal of pharmacology and experimental therapeutics
Storch CH,Ehehalt R,Haefeli WE,Weiss J
13-6800 was used in western blot to elucidate the compartmentalization of breast cancer resistance protein ABCG2 in the plasma membrane and the influence of membrane cholesterol on its efflux activity
Mon Oct 01 00:00:00 EDT 2007
Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking.
Experimental cell research
Lakkaraju AK,Luyet PP,Parone P,Falguières T,Strub K
13-6800 was used in immunocytochemistry and western blot to investigate the cellular function of signal recognition particle
Thu Feb 15 00:00:00 EST 2007
Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts.
FEBS letters
Gil C,Cubí R,Aguilera J
13-6800 was used in western blot to identify a role for lipid rafts in the modulation of the shedding of the neurotrophin receptor p75
Tue May 01 00:00:00 EDT 2007
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells.
Molecular biology of the cell
Oztan A,Silvis M,Weisz OA,Bradbury NA,Hsu SC,Goldenring JR,Yeaman C,Apodaca G
13-6800 was used in immunocytochemistry and western blot to assess if the exocyst complex is a multipurpose regulator of endocytic traffic directed toward both poles of polarized epithelial cells
Mon Oct 01 00:00:00 EDT 2007
Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.
Molecular biology of the cell
Ma H,Pederson T
Sun Jul 01 00:00:00 EDT 2007
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
Molecular biology of the cell
Johnson MB,Chen J,Murchison N,Green FA,Enns CA
Thu Mar 01 00:00:00 EST 2007
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
Molecular biology of the cell
Johnson MB,Chen J,Murchison N,Green FA,Enns CA
Thu Mar 01 00:00:00 EST 2007
Pael receptor is involved in dopamine metabolism in the nigrostriatal system.
Neuroscience research
Imai Y,Inoue H,Kataoka A,Hua-Qin W,Masuda M,Ikeda T,Tsukita K,Soda M,Kodama T,Fuwa T,Honda Y,Kaneko S,Matsumoto S,Wakamatsu K,Ito S,Miura M,Aosaki T,Itohara S,Takahashi R
13-6800 was used in western blot to analyze the role of Pael receptor expression in regulating dopamine levels in dopaminergic neurons
Sat Dec 01 00:00:00 EST 2007
Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells.
Histochemistry and cell biology
Schwab W,Harada H,Goetz W,Nowicki M,Witt M,Kasper M,Barth K
13-6800 was used in western blot to test if the extracellular matrix metalloproteinase inducer takes part in the induction of proteolytic enzymes in the rat tooth germ
Sat Sep 01 00:00:00 EDT 2007
Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains.
PloS one
Ignoul S,Simaels J,Hermans D,Annaert W,Eggermont J
13-6800 was used in immunocytochemistry and western blot to discuss functions regulated by human ClC-6
Wed May 30 00:00:00 EDT 2007
The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin.
The Journal of biological chemistry
Zhao Z,Li X,Hao J,Winston JH,Weinman SA
13-6800 was used in western blot to identify the pathways and regulation of ClC-3 trafficking to intracellular sites
Fri Sep 28 00:00:00 EDT 2007
Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells.
Archives of histology and cytology
Hida T,Ikeda H,Kametaka S,Akazawa C,Kohsaka S,Ebisu S,Uchiyama Y,Waguri S
13-6800 was used in western blot to explore the roles of GGA2 in lysosomal enzyme transport
Sat Dec 01 00:00:00 EST 2007
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
The Journal of biological chemistry
Chen J,Enns CA
Fri Mar 02 00:00:00 EST 2007
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
The Journal of biological chemistry
Chen J,Enns CA
Fri Mar 02 00:00:00 EST 2007
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
The Journal of biological chemistry
Chen J,Enns CA
Fri Mar 02 00:00:00 EST 2007
The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein.
Biochimica et biophysica acta
Fu D,van Dam EM,Brymora A,Duggin IG,Robinson PJ,Roufogalis BD
13-6800 was used in immunocytochemistry to determine the effects of Rab5 and RalA on the intracellular trafficking of p-glycoprotein
Sun Jul 01 00:00:00 EDT 2007
Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.
Blood
Ng PP,Helguera G,Daniels TR,Lomas SZ,Rodriguez JA,Schiller G,Bonavida B,Morrison SL,Penichet ML
13-6800 was used in immunocytochemistry and western blot to elucidate the mechanism of cell death induced by anti-transferrin receptor antibodies
Sun Oct 15 00:00:00 EDT 2006
The HIV lipidome: a raft with an unusual composition.
Proceedings of the National Academy of Sciences of the United States of America
Brügger B,Glass B,Haberkant P,Leibrecht I,Wieland FT,Kräusslich HG
Tue Feb 21 00:00:00 EST 2006
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Journal of cell science
Lerdrup M,Hommelgaard AM,Grandal M,van Deurs B
13-6800 was used in western blot to investigate ErbB2 internalization
Sun Jan 01 00:00:00 EST 2006
Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.
International immunology
Barel MT,Pizzato N,Le Bouteiller P,Wiertz EJ,Lenfant F
13-6800 was used in flow cytometry to identify the residues responsible for the resistance or sensitivity of MHC class I molecules to US2- and US11-mediated down-regulation
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Molecular and cellular biology
Matallanas D,Sanz-Moreno V,Arozarena I,Calvo F,Agudo-Ibáñez L,Santos E,Berciano MT,Crespo P
Sun Jan 01 00:00:00 EST 2006
Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.
DNA repair
Shackelford RE,Fu Y,Manuszak RP,Brooks TC,Sequeira AP,Wang S,Lowery-Nordberg M,Chen A
13-6800 was used in western blot to test if iron chelators reduce ataxia-telangiectasia cell chromosomal breaks
Wed Nov 08 00:00:00 EST 2006
Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.
Molecular immunology
Barel MT,Hassink GC,van Voorden S,Wiertz EJ
13-6800 was used in western blot to report that US2 and US11 from human cytomegalovirus target unassembled heavy chains for degradation
Wed Mar 01 00:00:00 EST 2006
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
Virology
Fackler OT,Moris A,Tibroni N,Giese SI,Glass B,Schwartz O,Kräusslich HG
13-6800 was used in Western Blot to characterise HIV-1 Nef mutants in the context of viral infection.
Tue Aug 01 00:00:00 EDT 2006
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
American journal of physiology. Regulatory, integrative and comparative physiology
Reversi A,Rimoldi V,Brambillasca S,Chini B
13-6800 was used in western blot to test if modulation of total cell cholesterol influences oxytocin receptors localization and signaling
Sun Oct 01 00:00:00 EDT 2006
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.
Nature
Zeng X,Tamai K,Doble B,Li S,Huang H,Habas R,Okamura H,Woodgett J,He X
13-6800 was used in western blot to identify GSK3 as a kinase that phosphorylates LRP6
Thu Dec 08 00:00:00 EST 2005
Microanatomy of axon/glial signaling during Wallerian degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Guertin AD,Zhang DP,Mak KS,Alberta JA,Kim HA
Wed Mar 30 00:00:00 EST 2005
Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus.
Journal of virology
Berryman S,Clark S,Monaghan P,Jackson T
13-6800 was used in immunocytochemistry to report that foot-and-mouth disease virus infection proceeds via clathrin-dependent endocytosis
Fri Jul 01 00:00:00 EDT 2005
Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects.
Journal of cell science
Doyotte A,Russell MR,Hopkins CR,Woodman PG
13-6800 was used in immunocytochemistry to investigate the sorting of cargo receptors
Fri Jul 15 00:00:00 EDT 2005
Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells.
Journal of cell science
Salazar G,Craige B,Love R,Kalman D,Faundez V
13-6800 was used in western blot to propose that the coupling of zinc transporter 3 and Vglut1 transport mechanisms regulates neurotransmitter content in secretory vesicles
Sun May 01 00:00:00 EDT 2005
Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.
Journal of neuroscience research
Fassa A,Mehta P,Efthimiopoulos S
Sat Oct 15 00:00:00 EDT 2005
Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.
Journal of neuroscience research
Fassa A,Mehta P,Efthimiopoulos S
Sat Oct 15 00:00:00 EDT 2005
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.
Molecular biology of the cell
Theos AC,Tenza D,Martina JA,Hurbain I,Peden AA,Sviderskaya EV,Stewart A,Robinson MS,Bennett DC,Cutler DF,Bonifacino JS,Marks MS,Raposo G
13-6800 was used in immunocytochemistry to report that AP-3 and AP-1 function independently in sorting tyrosinase from endosomes to the melanosome
Tue Nov 01 00:00:00 EST 2005
Two mink parvoviruses use different cellular receptors for entry into CRFK cells.
Virology
Park GS,Best SM,Bloom ME
13-6800 was used in immunocytochemistry to report that the transferrin receptor is a receptor for mink enteritis virus, but not Aleutian mink disease parvovirus
Thu Sep 15 00:00:00 EDT 2005
Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells.
Journal of radiation research
Chen Z,Nomura J,Suzuki T,Suzuki N
13-6800 was used in flow cytometry and western blot to propose that transferrin receptor expression is involved in the regulation of ultraviolet light-resistance
Thu Dec 01 00:00:00 EST 2005
CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.
Methods in enzymology
Monzo P,Mari M,Kaddai V,Gonzalez T,Le Marchand-Brustel Y,Cormont M
13-6800 was used in western blot elucidate the interactions among Rab4a, Rabip4, and CD2AP
Tue Apr 25 00:00:00 EDT 2006
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
The Journal of biological chemistry
Snyder EM,Colledge M,Crozier RA,Chen WS,Scott JD,Bear MF
Fri Apr 29 00:00:00 EDT 2005
Endocytosis resumes during late mitosis and is required for cytokinesis.
The Journal of biological chemistry
Schweitzer JK,Burke EE,Goodson HV,D'Souza-Schorey C
Fri Dec 16 00:00:00 EST 2005
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
The Journal of biological chemistry
Fotinopoulou A,Tsachaki M,Vlavaki M,Poulopoulos A,Rostagno A,Frangione B,Ghiso J,Efthimiopoulos S
Fri Sep 02 00:00:00 EDT 2005
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
The Journal of biological chemistry
Fotinopoulou A,Tsachaki M,Vlavaki M,Poulopoulos A,Rostagno A,Frangione B,Ghiso J,Efthimiopoulos S
Fri Sep 02 00:00:00 EDT 2005
The DnaJ-domain protein RME-8 functions in endosomal trafficking.
The Journal of biological chemistry
Girard M,Poupon V,Blondeau F,McPherson PS
Fri Dec 02 00:00:00 EST 2005
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
The Journal of biological chemistry
Alberghini A,Recalcati S,Tacchini L,Santambrogio P,Campanella A,Cairo G
Fri Aug 26 00:00:00 EDT 2005
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
The Journal of biological chemistry
Alberghini A,Recalcati S,Tacchini L,Santambrogio P,Campanella A,Cairo G
Fri Aug 26 00:00:00 EDT 2005
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
The Journal of biological chemistry
Pike LJ,Han X,Gross RW
Fri Jul 22 00:00:00 EDT 2005
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes.
The Journal of clinical investigation
Chuang JZ,Vega C,Jun W,Sung CH
13-6800 was used in immunocytochemistry to identify and study class III rhodopsin mutations
Thu Jul 01 00:00:00 EDT 2004
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
The Journal of experimental medicine
Eleme K,Taner SB,Onfelt B,Collinson LM,McCann FE,Chalupny NJ,Cosman D,Hopkins C,Magee AI,Davis DM
13-6800 was used in immunocytochemistry and western blot to study the modification of major histocompatibility complex class I-related chain A and UL16-binding proteins 1, 2, and 3
Mon Apr 05 00:00:00 EDT 2004
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
The Journal of experimental medicine
Eleme K,Taner SB,Onfelt B,Collinson LM,McCann FE,Chalupny NJ,Cosman D,Hopkins C,Magee AI,Davis DM
13-6800 was used in immunocytochemistry and western blot to study the modification of major histocompatibility complex class I-related chain A and UL16-binding proteins 1, 2, and 3
Mon Apr 05 00:00:00 EDT 2004
Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Gonçalves C,Mennesson E,Fuchs R,Gorvel JP,Midoux P,Pichon C
13-6800 was used in Flow Cytometry to investigate the internalisation and trafficking of polyplexes in HepG2 cells.
Sun Aug 01 00:00:00 EDT 2004
Recombinant Escherichia coli as a gene delivery vector into airway epithelial cells.
Journal of controlled release : official journal of the Controlled Release Society
Fajac I,Grosse S,Collombet JM,Thevenot G,Goussard S,Danel C,Grillot-Courvalin C
13-6800 was used in immunocytochemistry to discuss methods to transfer genes into airway epithelial cells
Fri Jun 18 00:00:00 EDT 2004
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
The Journal of cell biology
Arighi CN,Hartnell LM,Aguilar RC,Haft CR,Bonifacino JS
13-6800 was used in immunocytochemistry to elucidate the mechanisms that regulate the retrieval of the cation-independent mannose 6-phosphate receptor
Thu Apr 01 00:00:00 EST 2004
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.
Journal of virology
Krautkrämer E,Giese SI,Gasteier JE,Muranyi W,Fackler OT
13-6800 was used in Western Blot to determine how and in which subcellular compartment Nef triggers signalling.
Thu Apr 01 00:00:00 EST 2004
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.
Journal of immunology (Baltimore, Md. : 1950)
Batista A,Millán J,Mittelbrunn M,Sánchez-Madrid F,Alonso MA
13-6800 was used in western blot to study the localization of the transferrin receptor during the formation of the immunological synapse.
Tue Jun 01 00:00:00 EDT 2004
Cellular senescence induced loss of stem cell proportion in the skin in vitro.
Journal of dermatological science
Youn SW,Kim DS,Cho HJ,Jeon SE,Bae IH,Yoon HJ,Park KC
13-6800 was used in immunohistochemistry - paraffin section and western blot to study K19 in aged keratinocytes
Sun Aug 01 00:00:00 EDT 2004
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
American journal of physiology. Cell physiology
Badizadegan K,Wheeler HE,Fujinaga Y,Lencer WI
Mon Nov 01 00:00:00 EST 2004
Multiple regions contribute to membrane targeting of Rab GTPases.
Journal of cell science
Ali BR,Wasmeier C,Lamoreux L,Strom M,Seabra MC
13-6800 was used in immunocytochemistry to study the contribution of membrane targeting of Rab GTPases in multiple regions
Wed Dec 15 00:00:00 EST 2004
The GDP-bound form of Arf6 is located at the plasma membrane.
Journal of cell science
Macia E,Luton F,Partisani M,Cherfils J,Chardin P,Franco M
Sat May 01 00:00:00 EDT 2004
Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.
Journal of cellular biochemistry
Laham N,Rotem-Yehudar R,Shechter C,Coligan JE,Ehrlich R
13-6800 was used in immunoprecipitation and western blot to study the regulation and function of soluble beta2microglobulin-HFE monochain and transferrin receptor
Thu Apr 15 00:00:00 EDT 2004
Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.
Journal of cellular biochemistry
Laham N,Rotem-Yehudar R,Shechter C,Coligan JE,Ehrlich R
13-6800 was used in immunoprecipitation and western blot to study the regulation and function of soluble beta2microglobulin-HFE monochain and transferrin receptor
Thu Apr 15 00:00:00 EDT 2004
Adaptive changes of duodenal iron transport proteins in celiac disease.
Physiological genomics
Barisani D,Parafioriti A,Bardella MT,Zoller H,Conte D,Armiraglio E,Trovato C,Koch RO,Weiss G
Wed May 19 00:00:00 EDT 2004
Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes.
The journal of gene medicine
Grosse S,Aron Y,Honoré I,Thévenot G,Danel C,Roche AC,Monsigny M,Fajac I
13-6800 was used in immunocytochemistry to investigate the contribution of the lactose residue on the gene transfer efficiency of lactosylated polyethylenimine
Mon Mar 01 00:00:00 EST 2004
Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity.
Experimental cell research
Burgueño J,Canela EI,Mallol J,Lluis C,Franco R,Ciruela F
13-6800 was used in western blot to characterize the molecular and functional interaction between metabotropic glutamate receptor type 1alpha and caveolin-1 or caveolin-2beta
Fri Oct 15 00:00:00 EDT 2004
Regulation of a COPII component by cytosolic O-glycosylation during mitosis.
FEBS letters
Dudognon P,Maeder-Garavaglia C,Carpentier JL,Paccaud JP
13-6800 was used in western blot to elucidate how endoplasmic reticulum-to-Golgi transport is blocked during mitosis
Fri Mar 12 00:00:00 EST 2004
The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.
Molecular biology of the cell
Salazar G,Love R,Werner E,Doucette MM,Cheng S,Levey A,Faundez V
13-6800 was used in western blot to examine the composition of AP-2 dependent and AP-3 dependent synaptic vesicles.
Sun Feb 01 00:00:00 EST 2004
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.
Molecular biology of the cell
Williams R,Schlüter T,Roberts MS,Knauth P,Bohnensack R,Cutler DF
13-6800 was used in immunocytochemistry to report how the overexpression of SNX17 influences the endocytic trafficking of P-selectin
Thu Jul 01 00:00:00 EDT 2004
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
Molecular biology of the cell
Coumailleau F,Das V,Alcover A,Raposo G,Vandormael-Pournin S,Le Bras S,Baldacci P,Dautry-Varsat A,Babinet C,Cohen-Tannoudji M
13-6800 was used in immunocytochemistry and immunohistochemistry - frozen section to investigate the role of Rififylin in the endocytic recycling compartment
Fri Oct 01 00:00:00 EDT 2004
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.
Molecular biology of the cell
Luton F,Klein S,Chauvin JP,Le Bivic A,Bourgoin S,Franco M,Chardin P
13-6800 was used in western blot to determine the role of exchange factor for ARF6 during the development of epithelial cell polarity.
Mon Mar 01 00:00:00 EST 2004
BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.
Molecular biology of the cell
Shin HW,Morinaga N,Noda M,Nakayama K
13-6800 was used in immunocytochemistry to propose that BIG2 regulates the structural integrity of the recycling endosome through activating class I ADP-ribosylation factors
Wed Dec 01 00:00:00 EST 2004
The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton.
Molecular biology of the cell
Styers ML,Salazar G,Love R,Peden AA,Kowalczyk AP,Faundez V
13-6800 was used in immunocytochemistry to characterize the association between intermediate filament proteins and AP-3
Wed Dec 01 00:00:00 EST 2004
Charge-based separation of detergent-resistant membranes of mouse splenic B cells.
Biochemical and biophysical research communications
Katsumata O,Kimura T,Nagatsuka Y,Hirabayashi Y,Sugiya H,Furuyama S,Yanagishita M,Hara-Yokoyama M
13-6800 was used in western blot to use free-flow electrophoresis for the charge-based separation of detergent-resistant membranes
Fri Jul 02 00:00:00 EDT 2004
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain.
The Journal of biological chemistry
Stoorvogel W,Kerstens S,Fritzsche I,den Hartigh JC,Oud R,van der Heyden MA,Voortman J,van Bergen en Henegouwen PM
13-6800 was used in immunocytochemistry to investigate the transfer of endocytosed EGFR from endosomes to lysosomes.
Fri Mar 19 00:00:00 EST 2004
AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.
The Journal of biological chemistry
Salazar G,Love R,Styers ML,Werner E,Peden A,Rodriguez S,Gearing M,Wainer BH,Faundez V
13-6800 was used in western blot to identify a synaptic vesicle protein in which trafficking to synaptic vesicles is regulated by AP-3
Fri Jun 11 00:00:00 EDT 2004
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
The Journal of biological chemistry
Kikkert M,Doolman R,Dai M,Avner R,Hassink G,van Voorden S,Thanedar S,Roitelman J,Chau V,Wiertz E
13-6800 was used in immunoprecipitation to describe the structure and function of the putative human orthologue of yeast Hrd1p/Der3p.
Fri Jan 30 00:00:00 EST 2004
RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.
The Journal of biological chemistry
Denti S,Sirri A,Cheli A,Rogge L,Innamorati G,Putignano S,Fabbri M,Pardi R,Bianchi E
13-6800 was used in Western Blotting to suggest that RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways.
Fri Mar 26 00:00:00 EST 2004
Lipid raft-associated protein sorting in exosomes.
Blood
de Gassart A,Geminard C,Fevrier B,Raposo G,Vidal M
13-6800 was used in western blot to study specific sorting of proteins in exosomal membranes.
Mon Dec 15 00:00:00 EST 2003
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hering H,Lin CC,Sheng M
13-6800 was used in western blot to examine lipid rafts in the dendrites of cultured hippocampal neurons.
Tue Apr 15 00:00:00 EDT 2003
Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.
European journal of immunology
Barel MT,Pizzato N,van Leeuwen D,Bouteiller PL,Wiertz EJ,Lenfant F
13-6800 was used in immunoprecipitation to determine which domains of class I heavy chains bind to US11.
Sun Jun 01 00:00:00 EDT 2003
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.
Journal of neurochemistry
Burgueño J,Enrich C,Canela EI,Mallol J,Lluis C,Franco R,Ciruela F
13-6800 was used in western blot to report a molecular and functional association of mGlu1alpha receptor with caveolins.
Fri Aug 01 00:00:00 EDT 2003
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Journal of immunology (Baltimore, Md. : 1950)
Barel MT,Ressing M,Pizzato N,van Leeuwen D,Le Bouteiller P,Lenfant F,Wiertz EJ
Mon Dec 15 00:00:00 EST 2003
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Journal of immunology (Baltimore, Md. : 1950)
Barel MT,Ressing M,Pizzato N,van Leeuwen D,Le Bouteiller P,Lenfant F,Wiertz EJ
Mon Dec 15 00:00:00 EST 2003
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Journal of immunology (Baltimore, Md. : 1950)
Barel MT,Ressing M,Pizzato N,van Leeuwen D,Le Bouteiller P,Lenfant F,Wiertz EJ
Mon Dec 15 00:00:00 EST 2003
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Journal of immunology (Baltimore, Md. : 1950)
Barel MT,Ressing M,Pizzato N,van Leeuwen D,Le Bouteiller P,Lenfant F,Wiertz EJ
Mon Dec 15 00:00:00 EST 2003
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
Journal of immunology (Baltimore, Md. : 1950)
Sanjuán MA,Pradet-Balade B,Jones DR,Martínez-A C,Stone JC,Garcia-Sanz JA,Mérida I
13-6800 was used in western blot to examine the in vivo the regulation of DGK alpha.
Sat Mar 15 00:00:00 EST 2003
Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.
Carcinogenesis
Le NT,Richardson DR
13-6890 was used in western blot to characterize the effects of iron chelators on cell cycle arrest.
Sun Jun 01 00:00:00 EDT 2003
The role of c-Src in platelet-derived growth factor alpha receptor internalization.
Experimental cell research
Avrov K,Kazlauskas A
13-6800 was used in western blot to determine the role of Src family kinases in ligand-stimulated internalization of the platelet-derived growth factor alpha receptor
Wed Dec 10 00:00:00 EST 2003
Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.
Biochemical and biophysical research communications
Yamamoto Y,Nishimura N,Morimoto S,Kitamura H,Manabe S,Kanayama HO,Kagawa S,Sasaki T
13-6800 was used in western blot to examine the roles of Rab3B and Rab13 in regulating the cell-surface transport of apical p75 neurotrophin receptor, basolateral low-density lipoprotein receptor, and Claudin-1.
Fri Aug 22 00:00:00 EDT 2003
Association of human transferrin receptor with GABARAP.
FEBS letters
Green F,O'Hare T,Blackwell A,Enns CA
Wed May 08 00:00:00 EDT 2002
Association of human transferrin receptor with GABARAP.
FEBS letters
Green F,O'Hare T,Blackwell A,Enns CA
Wed May 08 00:00:00 EDT 2002
A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.
Analytical biochemistry
Vettermann C,Jäck HM,Mielenz D
13-6800 was used in western blot to describe methods for the assignment of immunoreactive spots in two-dimensional protein patterns.
Sun Sep 15 00:00:00 EDT 2002
Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.
The Journal of biological chemistry
Strick DJ,Francescutti DM,Zhao Y,Elferink LA
13-6800 was used in western blot to test if Rab15 interfere with Rab5 function directly or indirectly.
Fri Sep 06 00:00:00 EDT 2002
Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.
Blood
Fonseca AM,Porto G,Uchida K,Arosa FA
13-6800 was used in flow cytometry to determine a role of red blood cells in T-cell proliferation.
Tue May 15 00:00:00 EDT 2001
Afipia felis induces uptake by macrophages directly into a nonendocytic compartment.
Proceedings of the National Academy of Sciences of the United States of America
Luhrmann A,Streker K,Schüttfort A,Daniels JJ,Haas A
13-6800 was used in immunocytochemistry to determine the localization of Afipia felis in infected macrophages.
Tue Jun 19 00:00:00 EDT 2001
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.
Journal of virology
Parker JS,Murphy WJ,Wang D,O'Brien SJ,Parrish CR
Sun Apr 01 00:00:00 EST 2001
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.
Journal of virology
Parker JS,Murphy WJ,Wang D,O'Brien SJ,Parrish CR
Sun Apr 01 00:00:00 EST 2001
Antigen loading of MHC class I molecules in the endocytic tract.
Traffic (Copenhagen, Denmark)
Kleijmeer MJ,Escola JM,UytdeHaag FG,Jakobson E,Griffith JM,Osterhaus AD,Stoorvogel W,Melief CJ,Rabouille C,Geuze HJ
13-6800 was used in western blot to elucidate major histocompatibility complex class I trafficking.
Thu Feb 01 00:00:00 EST 2001
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
The European journal of neuroscience
Traiffort E,Moya KL,Faure H,Hässig R,Ruat M
13-6800 was used in western blot to study sonic hedgehog expression in developing and adult hamster brains
Sat Sep 01 00:00:00 EDT 2001
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
Molecular biology of the cell
Fraile-Ramos A,Kledal TN,Pelchen-Matthews A,Bowers K,Schwartz TW,Marsh M
13-6800 was used in immunocytochemistry to determine the cellular distribution and trafficking of a human cytomegalovirus chemokine receptor.
Fri Jun 01 00:00:00 EDT 2001
Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.
The Journal of biological chemistry
Abrami L,Fivaz M,Kobayashi T,Kinoshita T,Parton RG,van der Goot FG
Fri Aug 17 00:00:00 EDT 2001
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.
Cancer research
Hagihara N,Walbridge S,Olson AW,Oldfield EH,Youle RJ
13-6800 was used in western blot to study the use of Tf-CRM107 for brain tumor therapy.
Sat Jan 15 00:00:00 EST 2000
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
The Journal of cell biology
Sönnichsen B,De Renzis S,Nielsen E,Rietdorf J,Zerial M
13-6800 was used in immunocytochemistry to describe the membrane organization of the recycling pathway.
Mon May 15 00:00:00 EDT 2000
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.
Human molecular genetics
Hewett J,Gonzalez-Agosti C,Slater D,Ziefer P,Li S,Bergeron D,Jacoby DJ,Ozelius LJ,Ramesh V,Breakefield XO
13-6800 was used in immunocytochemistry to identify cellular changes induced byTOR1A mutations.
Mon May 22 00:00:00 EDT 2000
Brefeldin A-dependent membrane tubule formation reconstituted in vitro is driven by a cell cycle-regulated microtubule motor.
Molecular biology of the cell
Robertson AM,Allan VJ
13-6800 was used in immunocytochemistry to study brefeldin A-induced membrane tubule formation.
Wed Mar 01 00:00:00 EST 2000
High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
The Journal of biological chemistry
Uittenbogaard A,Shaul PW,Yuhanna IS,Blair A,Smart EJ
Fri Apr 14 00:00:00 EDT 2000
High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
The Journal of biological chemistry
Uittenbogaard A,Shaul PW,Yuhanna IS,Blair A,Smart EJ
Fri Apr 14 00:00:00 EDT 2000
High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
The Journal of biological chemistry
Uittenbogaard A,Shaul PW,Yuhanna IS,Blair A,Smart EJ
Fri Apr 14 00:00:00 EDT 2000
Rab15 differentially regulates early endocytic trafficking.
The Journal of biological chemistry
Zuk PA,Elferink LA
13-6800 was used in immunoprecipitation and western blot to elucidate the role of Rab15 in endocytosis.
Fri Sep 01 00:00:00 EDT 2000
Development, characterization, and use of monoclonal antibodies made to antigens expressed on the surface of fetal nucleated red blood cells.
Clinical chemistry
Alvarez FV,Olander J,Crimmins D,Prieto B,Paz A,Alonso R,Porter S,Hess J,Crist RD,Landt Y,Ladenson JH
Wed Sep 01 00:00:00 EDT 1999
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
The Journal of cell biology
Wang X,Kibschull M,Laue MM,Lichte B,Petrasch-Parwez E,Kilimann MW
13-6800 was used in immunocytochemistry to identify and characterize aczonin.
Mon Oct 04 00:00:00 EDT 1999
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
The Journal of cell biology
Wang X,Kibschull M,Laue MM,Lichte B,Petrasch-Parwez E,Kilimann MW
13-6800 was used in immunocytochemistry to identify and characterize aczonin.
Mon Oct 04 00:00:00 EDT 1999
Membrane trafficking regulates the activity of the human dopamine transporter.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Melikian HE,Buckley KM
13-6800 was used in western blot to study the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter.
Wed Sep 15 00:00:00 EDT 1999
Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle.
The Journal of biological chemistry
Gaschet J,Hsu VW
13-6800 was used in western blot to elucidate the regulation of the endocytic pathways by ARF6.
Fri Jul 09 00:00:00 EDT 1999
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
The Journal of biological chemistry
Attieh ZK,Mukhopadhyay CK,Seshadri V,Tripoulas NA,Fox PL
13-6800 was used in blocking assay to determine the mechanism by which ceruloplasmin stimulates cellular iron uptake.
Fri Jan 08 00:00:00 EST 1999
Separation and partial characterization of three distinct intracellular GLUT4 compartments in rat adipocytes. Subcellular fractionation without homogenization.
The Journal of biological chemistry
Lee W,Ryu J,Souto RP,Pilch PF,Jung CY
13-6800 was used in western blot to determine the subcellular localization of GLUT4.
Fri Dec 31 00:00:00 EST 1999
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
The Journal of biological chemistry
Zuk PA,Elferink LA
Fri Aug 06 00:00:00 EDT 1999
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
The Journal of biological chemistry
Zuk PA,Elferink LA
Fri Aug 06 00:00:00 EDT 1999
KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation.
The EMBO journal
Santama N,Krijnse-Locker J,Griffiths G,Noda Y,Hirokawa N,Dotti CG
13-6800 was used in immunocytochemistry to report that KIF2beta is a motor protein involved in peripheral translocation of lysosomes.
Thu Oct 15 00:00:00 EDT 1998
The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kamiguchi H,Long KE,Pendergast M,Schaefer AW,Rapoport I,Kirchhausen T,Lemmon V
13-6800 was used in immunocytochemistry to study L1 endocytosis.
Wed Jul 15 00:00:00 EDT 1998
Transferrin and transferrin receptor in human hypophysis and pituitary adenomas.
The American journal of pathology
Tampanaru-Sarmesiu A,Stefaneanu L,Thapar K,Kontogeorgos G,Sumi T,Kovacs K
13-6800 was used in immunohistochemistry - paraffin section to determine the the localization of transferrin and its receptor in human nontumorous autopsy pituitaries and surgically removed pituitary adenomas.
Sun Feb 01 00:00:00 EST 1998
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
The Journal of biological chemistry
Gross CN,Irrinki A,Feder JN,Enns CA
13-6800 was used in western blot to investigate the role of HFE in iron regulation.
Fri Aug 21 00:00:00 EDT 1998
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN.
The Journal of cell biology
Le Borgne R,Hoflack B
13-6800 was used in western blot to determine the effect of mannose 6-phosphate receptors on AP-1 localization.
Mon Apr 21 00:00:00 EDT 1997
