Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 3
TrxR1 Antibody (PA5-116094) in IHC (P)
Immunohistochemistry analysis of TrxR1 in mouse colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116094) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-116094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TXNRD1(Accession Q16881), corresponding to amino acid residues Y302-D323.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900728
Product Specific Information
Antibody detects endogenous levels of total TXNRD1.
Target Information
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; KM-102-derived reductase-like factor; MGC9145; NADPH-dependent thioredoxin reductase; oxidoreductase; Peroxidase TXNRD1; selenoprotein oxidoreductase; testis tissue sperm-binding protein Li 46a; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR alpha
Gene Aliases: GRIM-12; GRIM12; KDRF; TR; TR1; TRXR1; TXNR; TXNRD1
UniProt ID: (Human) Q16881, (Mouse) Q9JMH6
Entrez Gene ID: (Human) 7296, (Rat) 58819, (Mouse) 50493
thioredoxin-disulfide reductase activity
protein binding
electron carrier activity
protein disulfide oxidoreductase activity
flavin adenine dinucleotide binding
methylselenol reductase activity
methylseleninic acid reductase activity
mercury (II) reductase activity
NAD(P)H oxidase activity
selenate reductase activity
protein homodimerization activity
mercury ion binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
reductase
response to reactive oxygen species
mesoderm formation
selenium compound metabolic process
signal transduction
cell proliferation
nucleobase-containing small molecule interconversion
cell redox homeostasis
oxidation-reduction process
cellular oxidant detoxification
placenta development
glutathione metabolic process
response to oxidative stress
gastrulation
response to selenium ion
positive regulation of cell death
selenocysteine metabolic process
methylmercury metabolic process
response to drug
benzene-containing compound metabolic process
hydrogen peroxide catabolic process
response to axon injury
detoxification of mercury ion
protein tetramerization
response to hyperoxia
halogen metabolic process
NADPH oxidation
cellular response to copper ion
cellular response to hyperoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support