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Invitrogen
Tyrosine Hydroxylase Recombinant Superclonal Antibody (9HCLC)
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
Tyrosine Hydroxylase Antibody (710982) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized PC-3 cells for detection of TH using Anti-TH Recombinant Rabbit Polyclonal Antibody (Product # 710982, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of TH protein... View More
Product Details
710982
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
9HCLC
Immunogen
Protein corresponding to Human TH (aa 64-269)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2609672
Product Specific Information
This antibody is predicted to react with Monkey and Pig.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase
Gene Aliases: DYT14; DYT5b; TH; TYH
UniProt ID: (Human) P07101
Entrez Gene ID: (Human) 7054
response to hypoxia
synaptic transmission, dopaminergic
response to amphetamine
heart morphogenesis
dopamine biosynthetic process from tyrosine
fatty acid metabolic process
sphingolipid metabolic process
heart development
visual perception
sensory perception of sound
learning
memory
mating behavior
locomotory behavior
regulation of heart contraction
response to water deprivation
response to light stimulus
response to herbicide
response to salt stress
anatomical structure morphogenesis
organ morphogenesis
response to zinc ion
multicellular organism aging
response to activity
aminergic neurotransmitter loading into synaptic vesicle
glycoside metabolic process
phthalate metabolic process
cerebral cortex development
response to nutrient levels
response to estradiol
response to lipopolysaccharide
isoquinoline alkaloid metabolic process
social behavior
cellular response to drug
response to isolation stress
response to immobilization stress
neurotransmitter biosynthetic process
terpene metabolic process
dopamine biosynthetic process
epinephrine biosynthetic process
norepinephrine biosynthetic process
catecholamine biosynthetic process
eye photoreceptor cell development
circadian sleep/wake cycle
eating behavior
response to peptide hormone
pigmentation
response to ethanol
response to ether
response to pyrethroid
embryonic camera-type eye morphogenesis
response to corticosterone
response to electrical stimulus
phytoalexin metabolic process
oxidation-reduction process
cellular response to manganese ion
cellular response to nicotine
cellular response to glucose stimulus
cellular response to growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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