Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
68166-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B7E7
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: IPATALLPTM TPDGLAVTPT PVPVVGSQMT RQARRLYVGN IPFGITEEAM MDFFNAQMRL GGLTQAPGNP VLAVQINQDK NFAFLEFRSV DETTQAMAFD GIIFQGQSLK IRRPHDYQPL PGMSENPSVY VPGVVSTVVP DSAHKLFIGG LPNYLNDDQV KELLTSFGPL KAFNLVKDSA TGLSKGYAFC EYVDINVTDQ AIAGLNGMQL GDKKLLVQRA SVGAKNATLS TINQTPVTLQ VPGLMSSQVQ MGGHPTEVLC LMNMVLPEEL LDDEEYEEIV EDVRDECSKY GLVKSIEIPR PVDGVEVPGC GKIFVEFTSV FDCQKAMQGL TGRKFANRVV VTKYCDPDSY HRRDFW
Target Information
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: hU2AF(65); hU2AF65; Splicing factor U2AF 65 kDa subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa; U2 small nuclear RNA auxiliary factor 2; U2 snRNP auxiliary factor large subunit
Gene Aliases: 65kDa; U2AF2; U2AF65
UniProt ID: (Human) P26368, (Mouse) P26369
Entrez Gene ID: (Human) 11338, (Rat) 308335, (Mouse) 22185
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
mRNA processing
RNA export from nucleus
mRNA export from nucleus
mRNA 3'-end processing
positive regulation of RNA splicing
negative regulation of mRNA splicing, via spliceosome
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
RNA splicing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support