Product References
The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Molecular oncology
Wambecke A,Ahmad M,Morice PM,Lambert B,Weiswald LB,Vernon M,Vigneron N,Abeilard E,Brotin E,Figeac M,Gauduchon P,Poulain L,Denoyelle C,Meryet-Figuiere M
Published figure using UBC13 monoclonal antibody (Product # 37-1100) in Western Blot
Wed Dec 01 00:00:00 EST 2021
The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.
Molecular oncology
Wambecke A,Ahmad M,Morice PM,Lambert B,Weiswald LB,Vernon M,Vigneron N,Abeilard E,Brotin E,Figeac M,Gauduchon P,Poulain L,Denoyelle C,Meryet-Figuiere M
Published figure using UBC13 monoclonal antibody (Product # 37-1100) in Western Blot
Wed Dec 01 00:00:00 EST 2021
Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome.
Journal of immunology (Baltimore, Md. : 1950)
Ni J,Guan C,Liu H,Huang X,Yue J,Xiang H,Jiang Z,Tao Y,Cao W,Liu J,Wang Z,Wang Y,Wu X
37-1100 was used in Western Blotting to shed light on mechanisms of NLRP3 inflammasome activation and identifies that targeting Ubc13 could be an effective therapeutic strategy for treating aberrant NLRP3 inflammasome activation-induced pathogenesis.
Sat May 15 00:00:00 EDT 2021
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.
Nature communications
Wu X,Wang B
37-1100 was used in Western Blot to implicate Abraxas/BRCA1-A complex as a critical regulator that restrains BIR for protection of genome stability.
Fri Jul 16 00:00:00 EDT 2021
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.
Nature communications
Wu X,Wang B
37-1100 was used in Western Blot to implicate Abraxas/BRCA1-A complex as a critical regulator that restrains BIR for protection of genome stability.
Fri Jul 16 00:00:00 EDT 2021
Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation.
Cell reports
Lenoir JJ,Parisien JP,Horvath CM
37-1100 was used in Immunoprecipitation to establish a unifying mechanism for LGP2-mediated negative regulation that can modulate a variety of K63-Ub signaling pathways.
Tue Dec 28 00:00:00 EST 2021
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
The EMBO journal
Gan N,Guan H,Huang Y,Yu T,Fu J,Nakayasu ES,Puvar K,Das C,Wang D,Ouyang S,Luo ZQ
37-1100 was used in Western Blotting to establish a deubiquitination mechanism catalyzed by a deamidase, which, together with MavC, imposes temporal regulation of the activity of UBE2N during L. pneumophila infection.
Mon Feb 17 00:00:00 EST 2020
Advanced Cataloging of Lysine-63 Polyubiquitin Networks by Genomic, Interactome, and Sensor-Based Proteomic Analyses.
The Plant cell
Romero-Barrios N,Monachello D,Dolde U,Wong A,San Clemente H,Cayrel A,Johnson A,Lurin C,Vert G
37-1100 was used in Western Blotting to strongly increase our understanding of K63 polyubiquitination networks and functions in plants.
Wed Jan 01 00:00:00 EST 2020
Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nature communications
Puvar K,Iyer S,Fu J,Kenny S,Negrón Terón KI,Luo ZQ,Brzovic PS,Klevit RE,Das C
37-1100 was used in Western Blotting to demonstrate that Ubiquitin exhibits weak binding to MavC alone, but shows an increase in affinity when tethered to Ube2N in a disulfide-linked substrate that mimics the charged E2~Ub conjugate.
Tue May 12 00:00:00 EDT 2020
Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nature communications
Puvar K,Iyer S,Fu J,Kenny S,Negrón Terón KI,Luo ZQ,Brzovic PS,Klevit RE,Das C
37-1100 was used in Western Blotting to demonstrate that Ubiquitin exhibits weak binding to MavC alone, but shows an increase in affinity when tethered to Ube2N in a disulfide-linked substrate that mimics the charged E2~Ub conjugate.
Tue May 12 00:00:00 EDT 2020
Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N.
Nature microbiology
Gan N,Nakayasu ES,Hollenbeck PJ,Luo ZQ
37-1100 was used in Western Blotting to identify a mechanism by which Legionella pneumophila modifies a key ubiquitination enzyme by ubiquitin transglutamination in order to modulate host immunity.
Tue Jan 01 00:00:00 EST 2019
ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.
Molecular cell
Haahr P,Borgermann N,Guo X,Typas D,Achuthankutty D,Hoffmann S,Shearer R,Sixma TK,Mailand N
37-1100 was used in Western Blotting to study the role of zinc finger protein UFM1 specific peptidase domain protein on genome stability.
Thu Apr 05 00:00:00 EDT 2018
Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Zhang H,Li HS,Hillmer EJ,Zhao Y,Chrisikos TT,Hu H,Wu X,Thompson EJ,Clise-Dwyer K,Millerchip KA,Wei Y,Puebla-Osorio N,Kaushik S,Santos MA,Wang B,Garcia-Manero G,Wang J,Sun SC,Watowich SS
37-1100 was used in Western Blotting to elucidate a crucial role for STAT3 anti-inflammatory activity in the preservation of haematopoietic stem and progenitor cells and lineage-balanced haematopoiesis.
Tue Mar 06 00:00:00 EST 2018
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.
The Journal of biological chemistry
Pasupala N,Morrow ME,Que LT,Malynn BA,Ma A,Wolberger C
37-1100 was used in Western Blotting to elucidate a novel role for OTUB1-E2 interactions in modulating E2 protein ubiquitination.
Fri Nov 23 00:00:00 EST 2018
Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.
Molecular cell
Vujanovic M,Krietsch J,Raso MC,Terraneo N,Zellweger R,Schmid JA,Taglialatela A,Huang JW,Holland CL,Zwicky K,Herrador R,Jacobs H,Cortez D,Ciccia A,Penengo L,Lopes M
37-1100 was used in Western Blotting to show that damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains.
Thu Sep 07 00:00:00 EDT 2017
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
PLoS pathogens
Shibata Y,Tokunaga F,Goto E,Komatsu G,Gohda J,Saeki Y,Tanaka K,Takahashi H,Sawasaki T,Inoue S,Oshiumi H,Seya T,Nakano H,Tanaka Y,Iwai K,Inoue JI
371100 was used in western blot to discover that Tax recruits linear (Met1-linked) ubiquitin chain assembly complex to the IkB kinase complex
Sun Jan 01 00:00:00 EST 2017
A High-Throughput Screening Strategy for Development of RNF8-Ubc13 Protein-Protein Interaction Inhibitors.
SLAS discovery : advancing life sciences R & D
Weber E,Rothenaigner I,Brandner S,Hadian K,Schorpp K
371100 was used in western blot to find inhibitors of the RNF8-Ubc13 interaction
Wed Mar 01 00:00:00 EST 2017
Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.
PLoS pathogens
Pujari R,Hunte R,Thomas R,van der Weyden L,Rauch D,Ratner L,Nyborg JK,Ramos JC,Takai Y,Shembade N
37-1100 was used in Western Blotting to demonstrate that membrane associated Cell adhesion molecule1 recruits Ubc13 to Tax, causing K63-linked polyubiquitination of Tax, and IKK complex activation in the membrane lipid raft.
Sun Mar 01 00:00:00 EST 2015
Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
ACS chemical biology
Hodge CD,Edwards RA,Markin CJ,McDonald D,Pulvino M,Huen MS,Zhao J,Spyracopoulos L,Hendzel MJ,Glover JN
37-1100 was used in Western Blotting to elucidate the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damage and NF-κB signalling in human cells.
Fri Jul 17 00:00:00 EDT 2015
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
The Journal of experimental medicine
Fan Y,Mao R,Yu Y,Liu S,Shi Z,Cheng J,Zhang H,An L,Zhao Y,Xu X,Chen Z,Kogiso M,Zhang D,Zhang H,Zhang P,Jung JU,Li X,Xu G,Yang J
37-1100 was used in western blot to report a role for USP21 in the negative regulation of antiviral response through deubiquitinating RIG-I
Mon Feb 10 00:00:00 EST 2014
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Journal of cell science
Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W
Published figure using UBC13 monoclonal antibody (Product # 37-1100) in Western Blot
Fri Aug 15 00:00:00 EDT 2014
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.
Cell death & disease
Cheng J,Fan YH,Xu X,Zhang H,Dou J,Tang Y,Zhong X,Rojas Y,Yu Y,Zhao Y,Vasudevan SA,Zhang H,Nuchtern JG,Kim ES,Chen X,Lu F,Yang J
Published figure using UBC13 monoclonal antibody (Product # 37-1100) in Western Blot
Thu Feb 20 00:00:00 EST 2014
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.
Nature communications
Zhang H,Hu H,Greeley N,Jin J,Matthews AJ,Ohashi E,Caetano MS,Li HS,Wu X,Mandal PK,McMurray JS,Moghaddam SJ,Sun SC,Watowich SS
37-1100 was used in western blot to elucidate the mechanism by which STAT3 controls NF-kapaB signaling in innate immune cells.
Mon Dec 15 00:00:00 EST 2014
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Nature structural & molecular biology
Wiener R,DiBello AT,Lombardi PM,Guzzo CM,Zhang X,Matunis MJ,Wolberger C
37-1100 was used in western blot to assess the deubiquitinating activity of OTUB1 regulated by E2 ubiquitin-conjugating enzymes
Sun Sep 01 00:00:00 EDT 2013
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
Blood
Pulvino M,Liang Y,Oleksyn D,DeRan M,Van Pelt E,Shapiro J,Sanz I,Chen L,Zhao J
37-1100 was used in western blot to identify and characterize compounds that inhibit NF-κB activation in diffuse large B-cell lymphoma cells.
Thu Aug 23 00:00:00 EDT 2012
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Molecular cell
Ciccia A,Nimonkar AV,Hu Y,Hajdu I,Achar YJ,Izhar L,Petit SA,Adamson B,Yoon JC,Kowalczykowski SC,Livingston DM,Haracska L,Elledge SJ
37-1100 was used in western blot to study the role of ZRANB3 translocase during replication.
Fri Aug 10 00:00:00 EDT 2012
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Science (New York, N.Y.)
Cotta-Ramusino C,McDonald ER,Hurov K,Sowa ME,Harper JW,Elledge SJ
Published figure using UBC13 monoclonal antibody (Product # 37-1100) in Western Blot
Fri Jun 10 00:00:00 EDT 2011
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell
Stewart GS,Panier S,Townsend K,Al-Hakim AK,Kolas NK,Miller ES,Nakada S,Ylanko J,Olivarius S,Mendez M,Oldreive C,Wildenhain J,Tagliaferro A,Pelletier L,Taubenheim N,Durandy A,Byrd PJ,Stankovic T,Taylor AM,Durocher D
37-1100 was used in immunoprecipitation and western blot to show that RNF168 is mutated in individuals with RIDDLE syndrome
Fri Feb 06 00:00:00 EST 2009
Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
Proceedings of the National Academy of Sciences of the United States of America
Wu X,Yamamoto M,Akira S,Sun SC
Tue Dec 08 00:00:00 EST 2009
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
Molecular and cellular biology
Huen MS,Huang J,Yuan J,Yamamoto M,Akira S,Ashley C,Xiao W,Chen J
Wed Oct 01 00:00:00 EDT 2008
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
Molecular and cellular biology
Huen MS,Huang J,Yuan J,Yamamoto M,Akira S,Ashley C,Xiao W,Chen J
Wed Oct 01 00:00:00 EDT 2008
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
The Journal of biological chemistry
Sakasai R,Tibbetts R
37-1100 was used in western blot to investigate the potential role of the proteasome in checkpoint activation and ATM/ATR signaling in response to UV light-induced DNA damage
Fri May 16 00:00:00 EDT 2008
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Journal of virology
Shembade N,Harhaj NS,Yamamoto M,Akira S,Harhaj EW
37-1100 was used in immunoprecipitation and western blot to study the requirement of ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation by human T-cell leukemia virus 1 tax oncoprotein
Sat Dec 01 00:00:00 EST 2007
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Journal of immunology (Baltimore, Md. : 1950)
Yamamoto M,Sato S,Saitoh T,Sakurai H,Uematsu S,Kawai T,Ishii KJ,Takeuchi O,Akira S
37-1100 was used in western blot to determine the function of Ubc13 in T cell receptor-mediated signaling and responses
Fri Dec 01 00:00:00 EST 2006
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.
The EMBO journal
Habelhah H,Takahashi S,Cho SG,Kadoya T,Watanabe T,Ronai Z
Wed Jan 28 00:00:00 EST 2004
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.
Proceedings of the National Academy of Sciences of the United States of America
Ea CK,Sun L,Inoue J,Chen ZJ
Tue Oct 26 00:00:00 EDT 2004