Proteintech

UCP1 Polyclonal Antibody

UCP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

UCP1 Antibody (23673-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brown adipose tissue slide using (Product # 23673-1-AP) (UCP1 antibody) at dilution of 1:4,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

23673-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 58 publications 58 publications

Immunohistochemistry (IHC)

View 21 publications 21 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UCP1 Fusion Protein Ag20388 (1-307 aa encoded by BC098168)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGGLTASDV HPTLGVQLFS AGIAACLADV ITFPLDTAKV RLQVQGECPT SSVIRYKGVL GTITAVVKTE GRMKLYSGLP AGLQRQISSA SLRIGLYDTV QEFLTAGKET APSLGSKILA GLTTGGVAVF IGQPTEVVKV RLQAQSHLHG IKPRYTGTYN AYRIIATTEG LTGLWKGTTP NLMRSVIINC TELVTYDLMK EAFVKNNILA DDVPCHLVSA LIAGFCATAM SSPVDVVKTR FINSPPGQYK SVPNCAMKVF TNEGPTAFFK GLVPSFLRLG SWNVIMFVCF EQLKRELSKS RQTMDCAT (1-307 aa encoded by BC098168)

Target Information

Mitochondrial uncoupling proteins are members of the family of mitochondrial anion carrier proteins. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Wang Q,Dong Z,Liu X,Song X,Song Q,Shang Q,Jiang Y,Guo C,Zhang L

Sun Dec 01 00:00:00 EST 2013

Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue.

International journal of obesity (2005)

Gong FY,Zhang SJ,Deng JY,Zhu HJ,Pan H,Li NS,Shi YF

Tue Sep 01 00:00:00 EDT 2009

Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue.

International journal of obesity (2005)

Gong FY,Zhang SJ,Deng JY,Zhu HJ,Pan H,Li NS,Shi YF

Tue Sep 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: HGNC:12517; Mitochondrial brown fat uncoupling protein 1; Solute carrier family 25 member 7; Thermogenin; UCP 1; uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial

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Gene Aliases: AI385626; SLC25A7; UCP; UCP1; Ucpa; Uncp

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UniProt ID: (Human) P25874, (Rat) P04633, (Mouse) P12242

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Entrez Gene ID: (Human) 7350, (Rat) 24860, (Mouse) 22227

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Function(s)

structural constituent of ribosome oxidative phosphorylation uncoupler activity protein binding transporter secondary carrier transporter

Process(es)

regulation of transcription from RNA polymerase II promoter translation mitochondrial transport proton transport brown fat cell differentiation generation of precursor metabolites and energy cellular response to hormone stimulus positive regulation of multicellular organismal metabolic process response to steroid hormone transport transmembrane transport

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UCP1 Polyclonal Antibody

UCP1 Antibody (23673-1-AP) in IHC (P)

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23673-1-AP

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Immunocytochemistry (ICC/IF)

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