Proteintech

UGCG Polyclonal Antibody

View all (22) UGCG antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (10)

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

UGCG Antibody (12869-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma using 12869-1-AP (UGCG antibody) at dilution of 1:100 (under 40x lens).

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UGCG Antibody in Western Blot (WB)

UGCG Antibody in Western Blot (WB)

UGCG Antibody in Western Blot (WB)

UGCG Antibody in Western Blot (WB)

UGCG Antibody in Immunoprecipitation (IP)

Product Image Gallery

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lymphoma using 12869-1-AP (UGCG antibody) at dilution of 1:100 (under 40x lens).

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12869-1-AP (UGCG Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12869-1-AP (UGCG Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 12869-1-AP ( UGCG Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UGCG Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 12869-1-AP ( UGCG Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UGCG Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 12869-1-AP (UGCG antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

UGCG Antibody in Western Blot (WB) — U-251 cells were subjected to SDS PAGE followed by western blot with 12869-1-AP (UGCG Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

UGCG Antibody in Western Blot (WB) — A375 cells were subjected to SDS PAGE followed by western blot with 12869-1-AP (UGCG antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

UGCG Antibody in Western Blot (WB) — C6 cells were subjected to SDS PAGE followed by western blot with 12869-1-AP (UGCG Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

UGCG Antibody in Immunoprecipitation (IP) — IP result of anti-UGCG (IP:12869-1-AP, 4ug; Detection:12869-1-AP 1:500) with A375 cells lysate 3200ug.

Product Details

12869-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

-

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

-

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UGCG Fusion Protein Ag3530 (31-312 aa encoded by BC038711)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IYTRLHLNK KATDKQPYSK LPGVSLLKPL KGVDPNLINN LETFFELDYP KYEVLLCVQD HDDPAIDVCK KLLGKYPNVD ARLFIGGKKV GINPKINNLM PGYEVAKYDL IWICDSGIRV IPDTLTDMVN QMTEKVGLVH GLPYVADRQG FAATLEQVYF GTSHPRYYIS ANVTGFKCVT GMSCLMRKDV LDQAGGLIAF AQYIAEDYFM AKAIADRGWR FAMSTQVAMQ NSGSYSISQF QSRMIRWTKL RINMLPATII CEPISECFVA SLIIGWAAHH VFR (31-312 aa encoded by BC038711)

Target Information

May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalyzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids.

Nature communications

Liu J,van der Hoeven R,Kattan WE,Chang JT,Montufar-Solis D,Chen W,Wong M,Zhou Y,Lebrilla CB,Hancock JF

Sat Jan 28 00:00:00 EST 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.

Acta pharmacologica Sinica

Li ZB,Jiang L,Ni JD,Xu YH,Liu F,Liu WM,Wang SG,Liu ZQ,Wang CY

Thu Jun 01 00:00:00 EDT 2023

Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation.

iScience

Li Z,Chiang YP,He M,Worgall TS,Zhou H,Jiang XC

Fri Dec 17 00:00:00 EST 2021

Identification of long-term survival-associated gene in breast cancer.

Aging

Ning S,Li H,Qiao K,Wang Q,Shen M,Kang Y,Yin Y,Liu J,Liu L,Hou S,Wang J,Xu S,Pang D

Tue Oct 20 00:00:00 EDT 2020

Identification of long-term survival-associated gene in breast cancer.

Aging

Ning S,Li H,Qiao K,Wang Q,Shen M,Kang Y,Yin Y,Liu J,Liu L,Hou S,Wang J,Xu S,Pang D

Tue Oct 20 00:00:00 EDT 2020

A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells.

Frontiers in pharmacology

Han Y,Qu YQ,Mok SWF,Chen J,Xia CL,He HQ,Li Z,Zhang W,Qiu CL,Liu L,Law BYK,Wong VKW

Wed Sep 30 00:00:00 EDT 2020

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Human molecular genetics

Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL

Sun Dec 20 00:00:00 EST 2015

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Human molecular genetics

Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL

Sun Dec 20 00:00:00 EST 2015

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Human molecular genetics

Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL

Sun Dec 20 00:00:00 EST 2015

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Human molecular genetics

Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL

Sun Dec 20 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Ceramide glucosyltransferase; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:ceramide glycosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase

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Gene Aliases: AU043821; C80537; Epcs21; GCS; GlcT-1; GLCT1; UGCG; Ugcgl

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UniProt ID: (Human) Q16739, (Rat) Q9R0E0, (Mouse) O88693

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Entrez Gene ID: (Human) 7357, (Rat) 83626, (Mouse) 22234

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ceramide glucosyltransferase activity transferase activity transferase activity, transferring glycosyl groups glycosyltransferase

Process(es)

glucosylceramide biosynthetic process glycosphingolipid metabolic process glycosphingolipid biosynthetic process epidermis development positive regulation of protein targeting to mitochondrion lipid metabolic process sphingolipid metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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