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Product Details
PA5-55091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UNC13B. Recombinant protein control fragment (Product #RP-93102).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649265
Product Specific Information
Immunogen sequence: SQLSELDQYH EQDDDHRETD SIHSCHSSHS LSRDGQAGFG EQEKPLEVTG QAEKEAACEP KEMKEDATTH PP
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 69%.
Target Information
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B
Gene Aliases: MUNC13; UNC13; UNC13B; Unc13h2
UniProt ID: (Human) O14795
Entrez Gene ID: (Human) 10497
apoptotic process
signal transduction
chemical synaptic transmission
neurotransmitter secretion
neuromuscular junction development
excretion
positive regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle priming
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
innervation
positive regulation of inhibitory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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