Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: Raji.
Predicted reactivity: Human (99%), Mouse (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC34763; OTTHUMP00000016362; Protein unc-5 homolog C-like; unc-5 homolog C (C. elegans)-like; UNC5C-like protein; zu-5; ZU5 and death domain containing; ZU5 and death domain-containing protein
Gene Aliases: MUXA; UNC5CL; ZUD
UniProt ID: (Human) Q8IV45
Entrez Gene ID: (Human) 222643
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