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This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
USP6 is a deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. It catalyzes its own deubiquitination. In vitro, isoform2, but not isoform3, shows deubiquitinating activity. USP6 promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. It is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 6; hyperpolymorphic gene 1; Proto-oncogene TRE-2; RN-tre; TBC1D3 and USP32 fusion; Ubiquitin carboxyl-terminal hydrolase 6; ubiquitin specific peptidase 6 (Tre-2 oncogene); ubiquitin specific protease 6 (Tre-2 oncogene); Ubiquitin thioesterase 6; ubiquitin thiolesterase 6; ubiquitin-specific protease USP6; Ubiquitin-specific-processing protease 6
Gene Aliases: HRP1; Tre-2; TRE17; TRE2; TRESMCR; USP6; USP6-short
UniProt ID: (Human) P35125
Entrez Gene ID: (Human) 9098
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