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Product Details
23516-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Ubiquilin 1 Fusion Protein Ag20252 (1-561 aa encoded by BC010066)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects 70kD band of UBQLN1.
Immunogen sequence: MAESGESGG PPGSQDSAAG AEGAGAPAAA ASAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF KSHTDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDHSAQQ TNTAGSNVTT SSTPNSNSTS GSATSNPFGL GGLGGLAGLS SLGLNTTNFS ELQSQMQRQL LSNPEMMVQI MENPFVQSML SNPDLMRQLI MANPQMQQLI QRNPEISHML NNPDIMRQTL ELARNPAMMQ EMMRNQDRAL SNLESIPGGY NALRRMYTDI QEPMLSAAQE QFGGNPFASL VSNTSSGEGS QPSRTENRDP LPNPWAPQTS QSSSASSGTA STVGGTTGST ASGTSGQSTT APNLVPGVGA SMFNTPGMQS LLQQITENPQ LMQNMLSAPY MRSMMQSLSQ NPDLAAQMQN PDTLSAMSNP RAMQALLQIQ QGLQTLATEA PGLIPGFTPG LGALGSTGGS SGTNGSNATP SENTSPTAGT TEPGHQQFIQ QMLQALAGVN PQLQNPEVRF QQQLEQLSAM GFLNREANLQ ALIATGGDIN AAIERLLGSQ PS (1-561 aa encoded by BC010066)
Target Information
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hPLIC-1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; Ubiquilin-1
Gene Aliases: DA41; DSK2; PLIC-1; PLIC1; UBQLN1; UBQN; XDRP1
UniProt ID: (Human) Q9UMX0, (Rat) Q9JJP9
Entrez Gene ID: (Human) 29979, (Rat) 114590
autophagosome assembly
macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
regulation of protein ubiquitination
positive regulation of protein ubiquitination
negative regulation of toll-like receptor 3 signaling pathway
response to endoplasmic reticulum stress
aggrephagy
cellular response to hypoxia
autophagosome maturation
negative regulation of store-operated calcium channel activity
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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