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Invitrogen
Urokinase Recombinant Rabbit Monoclonal Antibody (JM106-09)
Product Details
MA5-32586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM106-09
Immunogen
Synthetic peptide within Human Urokinase aa 50-99
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809863
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antagonist of uPA; HGNC:9052; plasminogen activator; plasminogen activator, urinary; U-plasminogen activator; uPA; UPAR; Urinary plasminogen activator, urokinase; URKR; Urokinase-type plasminogen activator
Gene Aliases: ATF; BDPLT5; PLAU; QPD; u-PA; UPA; UPAM; URK
UniProt ID: (Human) P00749, (Mouse) P06869
Entrez Gene ID: (Human) 5328, (Rat) 25619, (Mouse) 18792
angiogenesis
proteolysis
chemotaxis
signal transduction
spermatogenesis
embryo implantation
blood coagulation
positive regulation of cell proliferation
regulation of receptor activity
response to activity
smooth muscle cell migration
regulation of smooth muscle cell migration
positive regulation of smooth muscle cell migration
positive regulation of cell migration
regulation of cell adhesion mediated by integrin
cellular response to hepatocyte growth factor stimulus
fibrinolysis
skeletal muscle tissue regeneration
response to hyperoxia
positive regulation of ovulation
regulation of wound healing
neuron death
cellular response to lipopolysaccharide
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to fluid shear stress
cellular response to staurosporine
regulation of smooth muscle cell-matrix adhesion
regulation of hepatocyte proliferation
positive regulation of reactive oxygen species metabolic process
response to hypoxia
phosphorylation
response to hepatocyte growth factor
wound healing
regulation of cell proliferation
cellular response to organic substance
plasminogen activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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