Product References
Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)n.
Cerebellum (London, England)
Aoki H,Higashi M,Okita M,Ando N,Murayama S,Ishikawa K,Yokota T
R961-25 was used in Western Blot to investigate TK2 and COX I expression in human postmortem SCA31 cerebellum.
Wed Feb 01 00:00:00 EST 2023
Spatial position is a key determinant of N-glycan functionality of the scavenger receptor cysteine-rich domain of human hepsin.
The FEBS journal
Sun S,Hu K,Wang L,Liu M,Zhang Y,Dong N,Wu Q
R961-25 was used in Immunoprecipitation to indicate that the spatial N-glycan positioning in the SRCR domain is a key determinant in the interaction with calnexin and subsequent cell surface expression of hepsin.
Tue Aug 01 00:00:00 EDT 2023
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.
The Journal of cell biology
Zheng J,Chen X,Liu Q,Zhong G,Zhuang M
R961-25 was used in Western Blot to show that MARCH5 is a dual-organelle locating protein that interacts with several peroxisomal proteins.
Mon Jan 03 00:00:00 EST 2022
A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis.
Nature communications
Páez-Moscoso DJ,Ho DV,Pan L,Hildebrand K,Jensen KL,Levy MJ,Florens L,Baumann P
R961-25 was used in Western Blot to assess whether Pof8, a member of the LARP7 protein family and a constitutive component of telomerase in fission yeast, has binding partners in addition to known telomerase components.
Fri Feb 25 00:00:00 EST 2022
TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis.
Cell death & disease
Shi JH,Ling C,Wang TT,Zhang LN,Liu WW,Qin Y,Tan YH,Cui NP,Ni ZY
R961-25 was used in Western Blot to determine the function of TRK-fused genes in LPS-induced inflammation and pyroptotic cell death.
Fri Jan 28 00:00:00 EST 2022
Development of a Competitive Enzyme-Linked Immunosorbent Assay Based on Purified Recombinant Viral Protein 7 for Serological Diagnosis of Epizootic Haemorrhagic Disease in Camels.
Journal of tropical medicine
Serroni A,Ulisse S,Iorio M,Laguardia C,Testa L,Armillotta G,Caporale M,Salini R,Lelli D,Wernery U,Raghavan R,Mercante MT,Di Ventura M
R961-25 was used in Western Blotting to produce a recombinant VP7 (recVP7) of EHDV serotype 2 in a baculovirus system, and after purification using ion metal affinity chromatography, obtain a high yield of recombinant protein characterized by a high degree of purity.
Fri Apr 01 00:00:00 EDT 2022
A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ.
Cell reports
Tang X,Arora G,Matias J,Hart T,Cui Y,Fikrig E
R961-25 was used in Pull-Down Assay to demonstrate that I. scapularis complement C1q-like protein 3 (IsC1ql3), a tick salivary protein, directly interacts with B. burgdorferi and is important during the initial stage of spirochetal infection of mice.
Tue Nov 22 00:00:00 EST 2022
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.
Frontiers in cellular and infection microbiology
Udawatte DJ,Lang DM,Currier JR,Medin CL,Rothman AL
R961-25 was used in ELISA, Western Blot, Immunoprecipitation to report that interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation, thus decreasing intracellular RIPK1 levels during DENV infection.
Thu Nov 03 00:00:00 EDT 2022
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.
Frontiers in cellular and infection microbiology
Udawatte DJ,Lang DM,Currier JR,Medin CL,Rothman AL
R961-25 was used in ELISA, Western Blot, Immunoprecipitation to report that interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation, thus decreasing intracellular RIPK1 levels during DENV infection.
Thu Nov 03 00:00:00 EDT 2022
Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulation.
The Journal of biological chemistry
Zhang Y,Sun S,Du C,Hu K,Zhang C,Liu M,Wu Q,Dong N
R961-25 was used in Western Blotting to examined two major post-translational events, zymogen activation and N-glycosylation, in human TMPRSS2 to provide new insights into the cellular mechanism in regulating TMPRSS2 biosynthesis and function.
Thu Dec 01 00:00:00 EST 2022
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell
Béziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet É,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Habib T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot É,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Prétet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL
R961-25 was used in Western Blotting to conclude that human CD28-dependent T cell responses are largely redundant for protective immunity.
Thu Jul 08 00:00:00 EDT 2021
Syntaxins 6 and 8 facilitate tau into secretory pathways.
The Biochemical journal
Lee WS,Tan DC,Deng Y,van Hummel A,Ippati S,Stevens C,Carmona-Mora P,Ariawan D,Hou L,Stefen H,Tomanic T,Bi M,Tomasetig F,Martin A,Fath T,Palmer S,Ke YD,Ittner LM
R961-25 was used in Western Blot to study the interactome of the C-terminal tail region of tau and show syntaxin 8 (STX8) as a mediator of tau release from cells.
Fri Apr 16 00:00:00 EDT 2021
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases.
Biochemistry
Ahmad Mokhtar AMB,Ahmed SBM,Darling NJ,Harris M,Mott HR,Owen D
R961-25 was used in Western Blot to show that levels of RhoA, RhoB, RhoC, Rac1, RhoH, and Wrch2/RhoV bound to GTP were found to decrease following coexpression with RhoGDI-3, confirming its role as a negative regulator of these small Rho GTPases.
Tue May 18 00:00:00 EDT 2021
Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling.
The Journal of clinical investigation
Zhang W,Li S,Lou J,Li H,Liu M,Dong N,Wu Q
R961-25 was used in Western Blotting to indicate that ANP promotes decidualization and TRAIL expression in endometrial stromal cells, contributing to sequential events in remodeling of spiral arteries, including SMC death and cyclophilin B release, which in turn induces TRAIL receptor expression and apoptosis in ECs.
Fri Oct 15 00:00:00 EDT 2021
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
The Journal of biological chemistry
Hurd CA,Brear P,Revell J,Ross S,Mott HR,Owen D
R961-25 was used in Western Blot to demonstrate if manipulation of a native binding partner can assist in the rational design of stapled peptide inhibitors targeting a protein-protein interaction.
Tue Aug 24 00:00:00 EDT 2021
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.
Nature communications
Zhang J,Guan X,Shah K,Yan J
R961-25 was used in Western Blot to reveal a putative RNA-binding protein to function as an NAADP receptor and a TPC regulatory protein and provides a molecular basis for understanding the mechanisms of NAADP signaling.
Fri Aug 06 00:00:00 EDT 2021
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Science advances
Pannecoucke E,Van Trimpont M,Desmet J,Pieters T,Reunes L,Demoen L,Vuylsteke M,Loverix S,Vandenbroucke K,Alard P,Henderikx P,Deroo S,Baatz F,Lorent E,Thiolloy S,Somers K,McGrath Y,Van Vlierberghe P,Lasters I,Savvides SN
R961-25 was used in an ELISA assay to demonstrate that the Alphabody scaffold can be engineered into a cell-penetrating protein antagonist against induced myeloid leukemia cell differentiation protein MCL-1, an intracellular target in cancer, by grafting the critical B-cell lymphoma 2 homology 3 helix of MCL-1 onto the Alphabody and tagging the scaffold's termini with designed cell-penetration polypeptides.
Mon Mar 01 00:00:00 EST 2021
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.
Cancer & metabolism
Liang RJ,Taylor S,Nahiyaan N,Song J,Murphy CJ,Dantas E,Cheng S,Hsu TW,Ramsamooj S,Grover R,Hwang SK,Ngo B,Cantley LC,Rhee KY,Goncalves MD
R961-25 was used in Western Blotting to show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation.
Wed Mar 24 00:00:00 EDT 2021
IKKε isoform switching governs the immune response against EV71 infection.
Communications biology
Chang YL,Liao YW,Chen MH,Chang SY,Huang YT,Ho BC,Yu SL
R961-25 was used in Immunocytochemistry to highlight a gene regulatory mechanism in pathogen-host interactions and provides a potential strategy for establishing host first-line defense against pathogens.
Wed Jun 02 00:00:00 EDT 2021
Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
Nature communications
Saad NY,Al-Kharsan M,Garwick-Coppens SE,Chermahini GA,Harper MA,Palo A,Boudreau RL,Harper SQ
R961-25 was used in Western Blotting to identify miR-675 as a natural DUX4 inhibitor that may have therapeutic applications for treating FSHD, and natural miR-675 variations among individual people could influence DUX4 expression, thereby justifying future examination of miR-675 as a potential disease modifier.
Wed Dec 08 00:00:00 EST 2021
Characterization of a Compound Heterozygous SLC2A9 Mutation That Causes Hypouricemia.
Biomedicines
Yoon J,Cachau R,David VA,Thompson M,Jung W,Jee SH,Daar IO,Winkler CA,Cho SK
R961-25 was used in Western Blotting to shed light on a better understanding of SLC2A9-mediated uric acid transport and the development of a uric acid-lowering agent.
Mon Sep 06 00:00:00 EDT 2021
Genome-Wide Analysis of Smad7-Mediated Transcription in Mouse Embryonic Stem Cells.
International journal of molecular sciences
Meng G,Lauria A,Maldotti M,Anselmi F,Polignano IL,Rapelli S,Donna D,Oliviero S
R961-25 was used in Western Blotting to establish Smad7 as a new, integral component of the regulatory circuitry that controls ESC identity.
Sat Dec 18 00:00:00 EST 2021
PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation.
Cell & bioscience
Saiada F,Zhang K,Li R
R961-25 was used in Western Blot to show that PIAS1 interacts with sterile alpha motif and HD domain 1 and promotes its SUMOylation.
Thu Jul 08 00:00:00 EDT 2021
RNF8 has both KU-dependent and independent roles in chromosomal break repair.
Nucleic acids research
Tsai LJ,Lopezcolorado FW,Bhargava R,Mendez-Dorantes C,Jahanshir E,Stark JM
R961-25 was used in Western Blotting to show that KU70, and hence the C-NHEJ pathway, is capable of mediating EJ events involving end resection and annealing of microhomology.
Fri Jun 19 00:00:00 EDT 2020
Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels.
Neuron
Tang YQ,Lee SA,Rahman M,Vanapalli SA,Lu H,Schafer WR
R961-25 was used in Western Blotting to identify UNC-44/ankyrin as an essential component of the TMC-1 mechanotransduction channel complex in the sensory cilia of Caenorhabditis elegans mechanoreceptor neurons.
Wed Jul 08 00:00:00 EDT 2020
Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling.
Cancer research
Chen J,Mitra A,Li S,Song S,Nguyen BN,Chen JS,Shin JH,Gough NR,Lin P,Obias V,He AR,Yao Z,Malta TM,Noushmehr H,Latham PS,Su X,Rashid A,Mishra B,Wu RC,Mishra L
R961-25 was used in Western Blotting to provide a novel mechanism regulating the tumor suppressor function of TGFβ in liver carcinogenesis.
Fri May 01 00:00:00 EDT 2020
Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses.
PLoS pathogens
Fiches GN,Zhou D,Kong W,Biswas A,Ahmed EH,Baiocchi RA,Zhu J,Santoso N
R961-25 was used in Chromatin immunoprecipitation to identify that immune related genes (IRGs) is a group of host genes preferentially silenced in EBV-positive gastric cancers through DNA hypermethylation.
Sat Aug 01 00:00:00 EDT 2020
Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature.
The CRISPR journal
Ubels JL,Diegel CR,Foxa GE,Ethen NJ,Lensing JN,Madaj ZB,Williams BO
R961-25 was used in Western Blotting to use CRISPR-Cas9-mediated gene editing to create strains of Lrp5-deficient rats and to determine whether knockout of Lrp5 resulted in phenotypes that model the bone and retina pathology in LRP5-deficient humans.
Sat Aug 01 00:00:00 EDT 2020
Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expression.
Virology
Zhang K,Lv DW,Li R
R961-25 was used in Western Blotting to establish IRF8 as a transcriptional activator in promoting EBV reactivation and defines PIAS1 as an inhibitor of IRF8 to limit lytic gene expression.
Wed Jan 15 00:00:00 EST 2020
A novel UBE3A sequence variant identified in eight related individuals with neurodevelopmental delay, results in a phenotype which does not match the clinical criteria of Angelman syndrome.
Molecular genetics & genomic medicine
Geerts-Haages A,Bossuyt SNV,den Besten I,Bruggenwirth H,van der Burgt I,Yntema HG,Punt AM,Brooks A,Elgersma Y,Distel B,Valstar M
R961-25 was used in Western Blotting to show that the p.(Asn340del) mutant protein behaves distinctly different from previously described Angelman syndrome-linked missense mutations in UBE3A, and causes a phenotype that is markedly different from Angelman syndrome.
Sun Nov 01 00:00:00 EDT 2020
Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura.
Haematologica
Graça NAG,Ercig B,Carolina Velásquez Pereira L,Kangro K,Kaijen P,Nicolaes GAF,Veyradier A,Coppo P,Vanhoorelbeke K,Männik A,Voorberg J
R961-25 was used in ELISA, Western Blot to provide a framework for the design of autoantibody-resistant ADAMTS13 variants for further therapeutic development.
Sun Nov 01 00:00:00 EDT 2020
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.
Nature communications
Sun P,Nie K,Zhu Y,Liu Y,Wu P,Liu Z,Du S,Fan H,Chen CH,Zhang R,Wang P,Cheng G
R961-25 was used in Western Blot to provide a mechanistic insight into saliva-aided viral transmission and could offer a potential prophylactic target for reducing flavivirus transmission.
Tue Jan 14 00:00:00 EST 2020
Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease.
The Journal of biological chemistry
Zhang C,Zhang Y,Zhang S,Wang Z,Sun S,Liu M,Chen Y,Dong N,Wu Q
R961-25 was used in Western Blotting to provide new insights into the diverse mechanisms in regulating TTSP activation.
Fri Sep 04 00:00:00 EDT 2020
A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells.
eLife
Zhang C,Chen Y,Sun S,Zhang Y,Wang L,Luo Z,Liu M,Dong L,Dong N,Wu Q
R961-25 was used in Western Blotting to report a conserved DSSDE motif in LDL-receptor (LDLR) modules of corin (a transmembrane serine protease) and CD320 (a receptor for vitamin B12 uptake), which regulates apical membrane targeting in renal epithelial cells.
Mon Nov 02 00:00:00 EST 2020
A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions.
PLoS genetics
Coste de Bagneaux P,von Elsner L,Bierhals T,Campiglio M,Johannsen J,Obermair GJ,Hempel M,Flucher BE,Kutsche K
R961-25 was used in Western Blotting to investigate the functional implications of a CACNB4 missense variant in siblings with severe neurological disorder.
Sun Mar 01 00:00:00 EST 2020
Direct evidence for a new mode of plant defense against insects via a novel polygalacturonase-inhibiting protein expression strategy.
The Journal of biological chemistry
Haeger W,Henning J,Heckel DG,Pauchet Y,Kirsch R
R961-25 was used in Western Blotting to indicate that plant PGIPs do not only confer resistance against phytopathogenic microorganisms, but also may play a role in plant defense against herbivorous beetles.
Fri Aug 14 00:00:00 EDT 2020
Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites.
Biomolecules
Pennarubia F,Pinault E,Al Jaam B,Brun CE,Maftah A,Germot A,Legardinier S
R961-25 was used in Western Blotting to perform a phylogenetic analysis on the distribution, conservation and evolution of Wif1 proteins.
Fri Aug 28 00:00:00 EDT 2020
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein.
Proteins
Strøm TB,Vinje T,Bjune K,da Costa LT,Laerdahl JK,Leren TP
R961-25 was used in Western Blotting to indicate that LAL is not a proprotein.
Sun Mar 01 00:00:00 EST 2020
Reaction Mechanisms of Pol IV, RDR2, and DCL3 Drive RNA Channeling in the siRNA-Directed DNA Methylation Pathway.
Molecular cell
Singh J,Mishra V,Wang F,Huang HY,Pikaard CS
R961-25 was used in Affinity purification to investigate he mechanisms that channel RNAs within specific pathways.
Thu Aug 08 00:00:00 EDT 2019
The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection.
The EMBO journal
Stempel M,Chan B,Juranić Lisnić V,Krmpotić A,Hartung J,Paludan SR,Füllbrunn N,Lemmermann NA,Brinkmann MM
R961-25 was used in Immunoprecipitation to show that MCMV has evolved a mechanism to specifically antagonize the STING-mediated antiviral IFN response, while preserving its pro-viral NF-κB response, providing an advantage in the establishment of an infection.
Fri Mar 01 00:00:00 EST 2019
Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease.
Antioxidants & redox signaling
Grossmann D,Berenguer-Escuder C,Bellet ME,Scheibner D,Bohler J,Massart F,Rapaport D,Skupin A,Fouquier d'Hérouël A,Sharma M,Ghelfi J,Raković A,Lichtner P,Antony P,Glaab E,May P,Dimmer KS,Fitzgerald JC,Grünewald A,Krüger R
R961-25 was used in Western Blotting to explore the genetic and functional contribution of RHOT1 mutations to Parkinson's disease in patient-derived cellular models.
Sun Dec 01 00:00:00 EST 2019
MCL1 and DEDD Promote Urothelial Carcinoma Progression.
Molecular cancer research : MCR
Hong AL,Guerriero JL,Doshi MB,Kynnap BD,Kim WJ,Schinzel AC,Modiste R,Schlauch AJ,Adam RM,Kwiatkowski DJ,Beroukhim R,Letai A,Rosenberg JE,Hahn WC
R961-25 was used in Flow cytometry/Cell sorting to assess whether the oncogene MCL1 and the genes that reside in the 1q23.3 amplicon are required for the proliferation or survival of urothelial carcinoma.
Sat Jun 01 00:00:00 EDT 2019
Epigenetic modulators hydralazine and sodium valproate act synergistically in VEGI-mediated anti-angiogenesis and VEGF interference in human osteosarcoma and vascular endothelial cells.
International journal of oncology
Kumanishi S,Yamanegi K,Nishiura H,Fujihara Y,Kobayashi K,Nakasho K,Futani H,Yoshiya S
R961-25 was used in Western Blotting to investigate the effect of the combination of DNA methyltransferase and histone deacetylase inhibitors on vascular endothelial growth inhibitor and death receptor-3.
Mon Jul 01 00:00:00 EDT 2019
N-Glycan-calnexin interactions in human factor VII secretion and deficiency.
The international journal of biochemistry & cell biology
Wang H,Wang L,Li S,Dong N,Wu Q
R961-25 was used in Western Blotting to show human FVII requires N-glycosylation at N360 in the protease domain in order to be secreted.
Thu Aug 01 00:00:00 EDT 2019
N-Glycan-calnexin interactions in human factor VII secretion and deficiency.
The international journal of biochemistry & cell biology
Wang H,Wang L,Li S,Dong N,Wu Q
R961-25 was used in Western Blotting to show human FVII requires N-glycosylation at N360 in the protease domain in order to be secreted.
Thu Aug 01 00:00:00 EDT 2019
Transcriptomic and Proteomic Approaches to Finding Novel Diagnostic and Immunogenic Candidates in Pneumocystis.
mSphere
Eddens T,Elsegeiny W,Ricks D,Goodwin M,Horne WT,Zheng M,Kolls JK
R961-25 was used in Western Blotting to outline a novel pipeline of -omics techniques capable of revealing novel antigens for the development of vaccines against Pneumocystis.
Wed Sep 04 00:00:00 EDT 2019
Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche.
eLife
Salazar VS,Capelo LP,Cantù C,Zimmerli D,Gosalia N,Pregizer S,Cox K,Ohte S,Feigenson M,Gamer L,Nyman JS,Carey DJ,Economides A,Basler K,Rosen V
R961-25 was used in Chromatin immunoprecipitation to study the requirement of BMP signalling at the innermost layer of the periosteal niche for the postnatal establishment of normal bone width in mice.
Fri Feb 08 00:00:00 EST 2019
Biochemical properties and subcellular localization of six members of the HXK family in maize and its metabolic contribution to embryo germination.
BMC plant biology
Aguilera-Alvarado GP,Guevara-García ÁA,Estrada-Antolín SA,Sánchez-Nieto S
R961-25 was used in Immunohistochemistry to clone and characterise putative catalytic enzymes of the hexokinase family in maize to analyse their metabolic contribution during germination process.
Tue Jan 15 00:00:00 EST 2019
An effective mouse model for adoptive cancer immunotherapy targeting neoantigens.
JCI insight
Hanada KI,Yu Z,Chappell GR,Park AS,Restifo NP
R961-25 was used in Western Blot to study the therapeutic effect of targeting a neoantigen with adoptive cell transfer.
Thu May 16 00:00:00 EDT 2019
Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity.
Cell death & disease
Ko YU,Kim C,Lee J,Kim D,Kim Y,Yun N,Oh YJ
R961-25 was used in Western Blotting to support the concepts of a molecular cascade in which Cdk5-mediated phosphorylation of Fbxw7 negatively regulates Fbxw7 expression, thereby contributing to neuronal cell death following glutamate-mediated excitotoxicity.
Fri Aug 02 00:00:00 EDT 2019
A threonyl-tRNA synthetase-mediated translation initiation machinery.
Nature communications
Jeong SJ,Park S,Nguyen LT,Hwang J,Lee EY,Giong HK,Lee JS,Yoon I,Lee JH,Kim JH,Kim HK,Kim D,Yang WS,Kim SY,Lee CY,Yu K,Sonenberg N,Kim MH,Kim S
R961-25 was used in Western Blotting to identify a threonyl-tRNA synthetase-mediated translation initiation machinery that specifically interacts with eIF4E homologous protein.
Fri Mar 22 00:00:00 EDT 2019
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
Nature immunology
Kong XF,Martinez-Barricarte R,Kennedy J,Mele F,Lazarov T,Deenick EK,Ma CS,Breton G,Lucero KB,Langlais D,Bousfiha A,Aytekin C,Markle J,Trouillet C,Jabot-Hanin F,Arlehamn CSL,Rao G,Picard C,Lasseau T,Latorre D,Hambleton S,Deswarte C,Itan Y,Abarca K,Moraes-Vasconcelos D,Ailal F,Ikinciogullari A,Dogu F,Benhsaien I,Sette A,Abel L,Boisson-Dupuis S,Schröder B,Nussenzweig MC,Liu K,Geissmann F,Tangye SG,Gros P,Sallusto F,Bustamante J,Casanova JL
R961-25 was used in Western Blotting to suggest that inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of cDC2s and impairing IFN-γ production by mycobacterium-specific memory TH1* cells.
Sat Sep 01 00:00:00 EDT 2018
A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer.
Cancer research
Zhang B,Chen MY,Shen YJ,Zhuo XB,Gao P,Zhou FS,Liang B,Zu J,Zhang Q,Suleman S,Xu YH,Xu MG,Xu JK,Liu CC,Giannareas N,Xia JH,Zhao Y,Huang ZL,Yang Z,Cheng HD,Li N,Hong YY,Li W,Zhang MJ,Yu KD,Li G,Sun MH,Chen ZD,Wei GH,Shao ZM
R961-25 was used in Western Blotting to reveal additional loci and new genes for genetic predisposition to breast cancer and highlights a polygenic basis of disease development.
Fri Jun 01 00:00:00 EDT 2018
Engineering rice with lower grain arsenic.
Plant biotechnology journal
Deng F,Yamaji N,Ma JF,Lee SK,Jeon JS,Martinoia E,Lee Y,Song WY
R961-25 was used in Western Blotting to investigate whether increasing arsenic vacuolar sequestration inhibits its translocation into the rice grain and reduce the amount of arsenic entering the food chain.
Mon Oct 01 00:00:00 EDT 2018
Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements.
Genes & development
Mendez-Dorantes C,Bhargava R,Stark JM
R961-25 was used in Western Blotting to study how the proximity of double stand breaks relative to repeat sequences affects their frequency.
Sun Apr 01 00:00:00 EDT 2018
EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.
Oncogene
Cho HJ,Hwang YS,Yoon J,Lee M,Lee HG,Daar IO
R961-25 was used in Western Blotting to connect the interaction between RhoGDI1 and ephrinB1 to the promotion of cancer cell behavior associated with tumor progression.
Thu Feb 15 00:00:00 EST 2018
Plastin 3 influences bone homeostasis through regulation of osteoclast activity.
Human molecular genetics
Neugebauer J,Heilig J,Hosseinibarkooie S,Ross BC,Mendoza-Ferreira N,Nolte F,Peters M,Hölker I,Hupperich K,Tschanz T,Grysko V,Zaucke F,Niehoff A,Wirth B
R961-25 was used in Western Blot to show that regulation of osteoclastogenesis and bone remodeling via the PLS3-NKRF-NFκB-NFATC1 axis unveils a novel possibility to counteract osteoporosis.
Sat Dec 15 00:00:00 EST 2018
Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.
Investigative ophthalmology & visual science
Michael HT,Graff-Cherry C,Chin S,Rauck C,Habtemichael AD,Bunda P,Smith T,Campos MM,Bharti K,Arnheiter H,Merlino G,Day CP
R961-25 was used in Western Blotting to investigate the ability of dopachrome tautomerase promoter-mediated inducible ectopic expression of Mitf-M to rescue phenotypic abnormalities including microphthalmia, retinal dysplasia, and albinism.
Mon Dec 03 00:00:00 EST 2018
NDUFA9 point mutations cause a variable mitochondrial complex I assembly defect.
Clinical genetics
Baertling F,Sánchez-Caballero L,van den Brand MAM,Fung CW,Chan SH,Wong VC,Hellebrekers DME,de Coo IFM,Smeitink JAM,Rodenburg RJT,Nijtmans LGJ
R961-25 was used in Western Blotting to demonstrate that the severity of the clinical NDUFA9 deficiency phenotype correlates with the severity of the effects of the different NDUFA9 variants on complex I assembly.
Mon Jan 01 00:00:00 EST 2018
A molecular switch orchestrates enzyme specificity and secretory granule morphology.
Nature communications
Ji S,Samara NL,Revoredo L,Zhang L,Tran DT,Muirhead K,Tabak LA,Ten Hagen KG
R961-25 was used in Western Blotting to identify a gene that influences the structure and shape of secretory granules within the Drosophila salivary gland.
Wed Aug 29 00:00:00 EDT 2018
N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding.
eLife
Wang H,Li S,Wang J,Chen S,Sun XL,Wu Q
R961-25 was used in Western Blotting to report a mechanism of N-glycosylation in protease domains of corin, enteropeptidase and prothrombin in calnexin-mediated glycoprotein folding and extracellular expression.
Mon Jun 11 00:00:00 EDT 2018
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.
Nature communications
Yan T,Ooi WF,Qamra A,Cheung A,Ma D,Sundaram GM,Xu C,Xing M,Poon L,Wang J,Loh YP,Ho JHJ,Ng JJQ,Ramlee MK,Aswad L,Rozen SG,Ghosh S,Bard FA,Sampath P,Tergaonkar V,Davies JOJ,Hughes JR,Goh E,Bi X,Fullwood MJ,Tan P,Li S
R961-25 was used in Chromatin immunoprecipitation to study how deregulation of HOXC5 and mir-615-3p expression may contribute to the activation of hTERT in human cancers.
Mon Jan 08 00:00:00 EST 2018
Pre-clinical Safety and Off-Target Studies to Support Translation of AAV-Mediated RNAi Therapy for FSHD.
Molecular therapy. Methods & clinical development
Wallace LM,Saad NY,Pyne NK,Fowler AM,Eidahl JO,Domire JS,Griffin DA,Herman AC,Sahenk Z,Rodino-Klapac LR,Harper SQ
R961-25 was used in Western Blotting to study improvements to RNAi vector design, and the expansion of the microRNA expression cassettes repertoire.
Fri Mar 16 00:00:00 EDT 2018
The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons.
Scientific reports
Lee J,Ko YU,Chung Y,Yun N,Kim M,Kim K,Oh YJ
R961-25 was used in Western Blotting to demonstrate a novel mechanism by which the acetylation of Cyclin-dependent kinase 5 at K33 results in the loss of ATP binding and impaired kinase activity.
Wed Sep 12 00:00:00 EDT 2018
New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia.
Scientific reports
Elbitar S,Susan-Resiga D,Ghaleb Y,El Khoury P,Peloso G,Stitziel N,Rabès JP,Carreau V,Hamelin J,Ben-Djoudi-Ouadda A,Bruckert E,Boileau C,Seidah NG,Varret M,Abifadel M
R961-25 was used in Western Blotting to identify new mutations in new or known genes implicated in autosomal dominant hypercholesterolaemia.
Wed Jan 31 00:00:00 EST 2018
AAV-mediated follistatin gene therapy improves functional outcomes in the TIC-DUX4 mouse model of FSHD.
JCI insight
Giesige CR,Wallace LM,Heller KN,Eidahl JO,Saad NY,Fowler AM,Pyne NK,Al-Kharsan M,Rashnonejad A,Chermahini GA,Domire JS,Mukweyi D,Garwick-Coppens SE,Guckes SM,McLaughlin KJ,Meyer K,Rodino-Klapac LR,Harper SQ
R961-25 was used in Western Blotting to develop a mouse model to study DUX4 toxicity, with relevance in therapeutic development studies for facioscapulohumeral muscular dystrophy.
Thu Nov 15 00:00:00 EST 2018
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes.
Nature
Liu Y,Liu J,Du S,Shan C,Nie K,Zhang R,Li XF,Zhang R,Wang T,Qin CF,Wang P,Shi PY,Cheng G
R961-25 was used in Western Blotting to study the importance of non-structural protein 1 antigenaemia in determining Zika virus infectivity in Aedes aegypti mosquitoes.
Thu May 25 00:00:00 EDT 2017
Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression.
Journal of molecular biology
Dyer JO,Dutta A,Gogol M,Weake VM,Dialynas G,Wu X,Seidel C,Zhang Y,Florens L,Washburn MP,Abmayr SM,Workman JL
R96125 was used in western blot to investigate Myeloid Leukemia Factor as a member of a nuclear chaperone complex containing a DnaJ protein, BAG2 and Hsc70
Fri Jun 30 00:00:00 EDT 2017
A versatile plasmid system for reconstitution and analysis of mammalian ubiquitination cascades in yeast.
Microbial cell (Graz, Austria)
Avagliano Trezza R,van den Burg J,van den Oever N,Distel B
R961-25 was used in Western Blotting to provide a versatile tool to study complex post-translational modifications in a cellular setting.
Tue Dec 05 00:00:00 EST 2017
A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export.
Journal of cell science
Sun J,Yu S,Zhang X,Capac C,Aligbe O,Daudelin T,Bonder EM,Gao N
R961-25 was used in Western Blotting to study the cellular mechanism underlying the initial assembly of Wnt secretory vesicles.
Sat Jul 01 00:00:00 EDT 2017
Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
Human mutation
Baertling F,Al-Murshedi F,Sánchez-Caballero L,Al-Senaidi K,Joshi NP,Venselaar H,van den Brand MA,Nijtmans LG,Rodenburg RJ
R96125 was used in western blot to present a function of COX5A in complex IV biogenesis
Thu Jun 01 00:00:00 EDT 2017
Saccharomyces cerevisiae Atf1p is an alcohol acetyltransferase and a thioesterase in vitro.
Yeast (Chichester, England)
Nancolas B,Bull ID,Stenner R,Dufour V,Curnow P
R96125 was used in western blot to indicate a role for Atf1p in coenzyme A homeostasis and propose that reducing the thioesterase activity of Atf1p could improve product yields of acetate esters
Thu Jun 01 00:00:00 EDT 2017
Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.
The Journal of biological chemistry
Verhelst J,Van Hoecke L,Spitaels J,De Vlieger D,Kolpe A,Saelens X
R96125 was used in western blot to characterize a mouse antiviral myxovirus resistance protein 1 variant that only exerts antiviral activity in the presence of a small molecule drug
Fri Feb 10 00:00:00 EST 2017
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
The Journal of biological chemistry
Shiraishi A,Uruno T,Sanematsu F,Ushijima M,Sakata D,Hara T,Fukui Y
R96125 was used in immunoprecipitation to find that DOCK8-deficient macrophages exhibit a migration defect in a two-dimensional setting
Fri Feb 10 00:00:00 EST 2017
The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.
The Journal of biological chemistry
Susan-Resiga D,Girard E,Kiss RS,Essalmani R,Hamelin J,Asselin MC,Awan Z,Butkinaree C,Fleury A,Soldera A,Dory YL,Baass A,Seidah NG
R961-25 was used in Western Blotting to demonstrate that low density lipoprotein receptor (LDLR)-R410S represents an LDLR loss-of-function through a novel class 8 Familial hypercholesterolemia-causing mechanism, thereby rationalising the observed phenotype.
Fri Feb 03 00:00:00 EST 2017
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Nature communications
Yamamura K,Uruno T,Shiraishi A,Tanaka Y,Ushijima M,Nakahara T,Watanabe M,Kido-Nakahara M,Tsuge I,Furue M,Fukui Y
R96125 was used in western blot to find that CD4+ T cells from DOCK8-deficient mice produce large amounts of IL-31
Mon Jan 09 00:00:00 EST 2017
Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery.
eLife
Mondal A,Dawson AR,Potts GK,Freiberger EC,Baker SF,Moser LA,Bernard KA,Coon JJ,Mehle A
R961-25 was used in Immunoprecipitation to demonstrate that human protein kinase C family members regulate ribonucleoprotein complex assembly for the influenza virus.
Mon Jul 31 00:00:00 EDT 2017
Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.
Proceedings of the National Academy of Sciences of the United States of America
Chaudhuri D,Artiga DJ,Abiria SA,Clapham DE
R961-25 was used in western blot to analyze regulation of the calcium threshold for the mitochondrial permeability transition by mitochondrial calcium uniporter regulator 1 (MCUR1)
Tue Mar 29 00:00:00 EDT 2016
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.
Proceedings of the National Academy of Sciences of the United States of America
Duffy S,Fam HK,Wang YK,Styles EB,Kim JH,Ang JS,Singh T,Larionov V,Shah SP,Andrews B,Boerkoel CF,Hieter P
R96125 was used in western blot to examine the role of gene overexpression on chromosome instability
Tue Sep 06 00:00:00 EDT 2016
Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4.
Human molecular genetics
Eidahl JO,Giesige CR,Domire JS,Wallace LM,Fowler AM,Guckes SM,Garwick-Coppens SE,Labhart P,Harper SQ
R961-25 was used in Western Blotting to suggest DUX4 and Dux may regulate common pathways, and despite millions of years of divergence, maintain partial functional homology.
Sat Oct 15 00:00:00 EDT 2016
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.
The Journal of biological chemistry
Hinds TD,Burns KA,Hosick PA,McBeth L,Nestor-Kalinoski A,Drummond HA,AlAmodi AA,Hankins MW,Vanden Heuvel JP,Stec DE
R961-25 was used in western blot identify and characterize a biliverdin reductase A-glycogen synthase kinase 3beta-peroxisome proliferator-activated receptor alpha axis that regulates hepatic lipid metabolism
Fri Nov 25 00:00:00 EST 2016
Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
eLife
Sharma V,Young L,Cavadas M,Owen K
R961-25 was used in western blot to learn about resistance to RAF inhibition through MAP kinase pathway reactivation by COT
Mon Mar 21 00:00:00 EDT 2016
Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits.
Scientific reports
Shimizu H,Miyazaki H,Ohsawa N,Shoji S,Ishizuka-Katsura Y,Tosaki A,Oyama F,Terada T,Sakamoto K,Shirouzu M,Sekine S,Nukina N,Yokoyama S
R961-25 was used in immunoprecipitation to characterize multimeric cell-adhesive interactions of voltage-gated sodium channel beta subunits by structure-based site-directed photo-crosslinking analyses
Tue May 24 00:00:00 EDT 2016
Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.
BMC biology
Maeso I,Dunwell TL,Wyatt CD,Marlétaz F,Vető B,Bernal JA,Quah S,Irimia M,Holland PW
R961-25 was used in Western Blotting to conclude that a dynamic chromosome region spawned a set of evolutionarily new homeobox genes, the ETCHbox genes, specifically in eutherian mammals.
Mon Jun 13 00:00:00 EDT 2016
FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).
The Journal of biological chemistry
Shao W,Zumer K,Fujinaga K,Peterlin BM
R96125 was used in western blot to investigate the phosphorylation and ubiquitylation of autoimmune regulator
Fri Aug 19 00:00:00 EDT 2016
Direct evidence of the molecular basis for biological silicon transport.
Nature communications
Knight MJ,Senior L,Nancolas B,Ratcliffe S,Curnow P
R961-25 was used in Western Blotting to study biological silicon transport using a new fluorescence method for studying substrate transport kinetics.
Thu Jun 16 00:00:00 EDT 2016
Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
PLoS genetics
Lakisic G,Lebreton A,Pourpre R,Wendling O,Libertini E,Radford EJ,Le Guillou M,Champy MF,Wattenhofer-Donzé M,Soubigou G,Ait-Si-Ali S,Feunteun J,Sorg T,Coppée JY,Ferguson-Smith AC,Cossart P,Bierne H
R961-25 was used in immunoprecipitation to elucidate the complex role of the BAHD1 c hromatin-repressive complex in regulation of steroid metabolism and placental development
Tue Mar 01 00:00:00 EST 2016
Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.
International journal of oncology
Rohrbach TD,Jarboe JS,Anderson JC,Trummell HQ,Hicks PH,Weaver AN,Yang ES,Oster RA,Deshane JS,Steele C,Siegal GP,Bonner JA,Willey CD
R961-25 was used in Western Blotting to study how the MARCKS ED appears to be an important target for lung cancer therapeutic development.
Sun Mar 01 00:00:00 EST 2015
Involvement of corin downregulation in ionizing radiation-induced senescence of myocardial cells.
International journal of molecular medicine
Kim EJ,Lee J,Jung YR,Park JJ,Park MJ,Lee JS,Kim CH,Lee YJ,Lee M
R961-25 was used in Western Blotting to investigate whether ionising radiation causes the onset of heart disease by inducing cellular senescence in cardiomyocytes.
Sun Mar 01 00:00:00 EST 2015
Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells.
International journal of hematology
Mizuno S,Hanamura I,Ota A,Karnan S,Narita T,Ri M,Mizutani M,Goto M,Gotou M,Tsunekawa N,Shikami M,Iida S,Hosokawa Y,Miwa H,Ueda R,Nitta M,Takami A
R961-25 was used in western blot to generate and characterize a human myeloma cell line
Sun Nov 01 00:00:00 EDT 2015
The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization.
PloS one
Rohrbach TD,Shah N,Jackson WP,Feeney EV,Scanlon S,Gish R,Khodadadi R,Hyde SO,Hicks PH,Anderson JC,Jarboe JS,Willey CD
R961-25 was used in immunocytochemistry and western blot to analyze regulation of cellular PIP2 levels and nuclear PIP2 localization by the effector domain of MARCKS which acts as a nuclear localization signal
Wed Jul 06 00:00:00 EDT 2016
Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.
PloS one
Witwicka H,Hwang SY,Reyes-Gutierrez P,Jia H,Odgren PE,Donahue LR,Birnbaum MJ,Odgren PR
R961-25 was used in Western Blotting to investigate osteoclast-stimulatory transmembrane protein function, topology, and posttranslational modification in a knockout mouse model.
Tue May 03 00:00:00 EDT 2016
Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.
The Journal of biological chemistry
van der Kant R,Jonker CT,Wijdeven RH,Bakker J,Janssen L,Klumperman J,Neefjes J
R961-25 was used in Western Blotting to provide a detailed analysis of interactions within the mammalian CORVET and HOPS as well as an additional endosomal-targeting complex (VIPAS39-VPS33B) that does not exist in yeast.
Fri Dec 18 00:00:00 EST 2015
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Nature communications
Yan Y,Tsukamoto O,Nakano A,Kato H,Kioka H,Ito N,Higo S,Yamazaki S,Shintani Y,Matsuoka K,Liao Y,Asanuma H,Asakura M,Takafuji K,Minamino T,Asano Y,Kitakaze M,Takashima S
R961-25 was used in immunoprecipitation and western blot to elucidate the mechanisms of AMP-activated protein kinase activation
Fri Jan 30 00:00:00 EST 2015
Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.
Nature medicine
Clement LC,Macé C,Avila-Casado C,Joles JA,Kersten S,Chugh SS
R961-25 was used in Western Blotting to show that plasma angiopoietin-like 4 links proteinuria with hypertriglyceridemia through two negative feedback loops.
Wed Jan 01 00:00:00 EST 2014
Immunohistological study of the endometrial stromal fibroblasts in the opossum, Monodelphis domestica: evidence for homology with eutherian stromal fibroblasts.
Biology of reproduction
Kin K,Maziarz J,Wagner GP
R961-25 was used in Western Blotting to examine the origin of decidual cells in Monodelphis domestica.
Thu May 01 00:00:00 EDT 2014
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Nature communications
Eberhardt M,Dux M,Namer B,Miljkovic J,Cordasic N,Will C,Kichko TI,de la Roche J,Fischer M,Suárez SA,Bikiel D,Dorsch K,Leffler A,Babes A,Lampert A,Lennerz JK,Jacobi J,Martí MA,Doctorovich F,Högestätt ED,Zygmunt PM,Ivanovic-Burmazovic I,Messlinger K,Reeh P,Filipovic MR
R961-25 was used in Western Blot to propose that the neuroendocrine HNO-TRPA1-CGRP signalling pathway constitutes a key element for vascular tone control throughout the cardiovascular system.
Tue Jul 15 00:00:00 EDT 2014
The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.
The Journal of biological chemistry
Lee CC,Freinkman E,Sabatini DM,Ploegh HL
R961-25 was used in Western Blotting to identify a role for leucine-rich repeat-containing 8 (LRRC8) proteins, which by forming one or more complexes mediate cell-cell communication by transporting small solutes.
Fri Jun 13 00:00:00 EDT 2014
Casein kinase 1δ-dependent Wee1 protein degradation.
The Journal of biological chemistry
Penas C,Ramachandran V,Simanski S,Lee C,Madoux F,Rahaim RJ,Chauhan R,Barnaby O,Schurer S,Hodder P,Steen J,Roush WR,Ayad NG
R961-25 was used in western blot to investigate the role of CK1delta in controlling the cell cycle
Fri Jul 04 00:00:00 EDT 2014
The leukemogenicity of Hoxa9 depends on alternative splicing.
Leukemia
Stadler CR,Vegi N,Mulaw MA,Edmaier KE,Rawat VP,Dolnik A,Bullinger L,Heilmeier B,Quintanilla-Fend L,Spiekermann K,Hiddemann W,Döhner K,Döhner H,Feuring-Buske M,Buske C
R961-25 was used in Western Blotting to assign splicing a central task in Hox gene mediated leukemogenesis and suggest an important role of homeodomain-less splice variants in hematological neoplasms.
Mon Sep 01 00:00:00 EDT 2014
Severe malaria is associated with parasite binding to endothelial protein C receptor.
Nature
Turner L,Lavstsen T,Berger SS,Wang CW,Petersen JE,Avril M,Brazier AJ,Freeth J,Jespersen JS,Nielsen MA,Magistrado P,Lusingu J,Smith JD,Higgins MK,Theander TG
R961-25 was used in an ELISA assay to identify endothelial protein C receptor as the endothelial receptor for domain cassettes 8 and 13 of P. falciparum erythrocyte membrane protein 1.
Thu Jun 27 00:00:00 EDT 2013
Albumin is recycled from the primary urine by tubular transcytosis.
Journal of the American Society of Nephrology : JASN
Tenten V,Menzel S,Kunter U,Sicking EM,van Roeyen CR,Sanden SK,Kaldenbach M,Boor P,Fuss A,Uhlig S,Lanzmich R,Willemsen B,Dijkman H,Grepl M,Wild K,Kriz W,Smeets B,Floege J,Moeller MJ
R961-25 was used in an ELISA assay to provide evidence of a transcytosis within the kidney tubular system that protects albumin and IgG from lysosomal degradation.
Sun Dec 01 00:00:00 EST 2013
PTL-1 regulates neuronal integrity and lifespan in C. elegans.
Journal of cell science
Chew YL,Fan X,Götz J,Nicholas HR
R961-25 was used in Western Blotting to suggest that some of the effects of tau pathology result from the loss of physiological tau function and not solely from a toxic gain-of-function due to accumulation of tau.
Wed May 01 00:00:00 EDT 2013
PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.
PloS one
Saavedra YG,Zhang J,Seidah NG
Tue Apr 15 00:00:00 EDT 2014
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
Nature immunology
Schneider M,Zimmermann AG,Roberts RA,Zhang L,Swanson KV,Wen H,Davis BK,Allen IC,Holl EK,Ye Z,Rahman AH,Conti BJ,Eitas TK,Koller BH,Ting JP
R961-25 was used in Western Blotting to elucidate the signalling interactions between NLR and TRAF proteins.
Sat Sep 01 00:00:00 EDT 2012
Mutagenesis of the palmitoylation site in vaccinia virus envelope glycoprotein B5.
The Journal of general virology
Lorenzo MM,Sánchez-Puig JM,Blasco R
R961-25 was used in Western blotting following immunoprecipitation to study the role of palmitoylation in the biogenesis of the enveloped vaccinia virus.
Sun Apr 01 00:00:00 EDT 2012
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
The Journal of biological chemistry
Clausen TM,Christoffersen S,Dahlbäck M,Langkilde AE,Jensen KE,Resende M,Agerbæk MØ,Andersen D,Berisha B,Ditlev SB,Pinto VV,Nielsen MA,Theander TG,Larsen S,Salanti A
R961-25 was used in an ELISA assay to model VAR2CSA and construct a small VAR2CSA antigen that has the capacity to induce highly adhesion-blocking antibodies.
Fri Jul 06 00:00:00 EDT 2012
Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells.
Journal of proteome research
Denis N,Palmer-Smith H,Elisma F,Busuttil A,Wright TG,Bou Khalil M,Prat A,Seidah NG,Chrétien M,Mayne J,Figeys D
R961-25 was used in western blot to elucidate how proprotein convertase subtilisin/kexin type 9 promotes degradation of the liver low-density lipoprotein receptor
Fri Apr 01 00:00:00 EDT 2011
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.
Science (New York, N.Y.)
Lebreton A,Lakisic G,Job V,Fritsch L,Tham TN,Camejo A,Matteï PJ,Regnault B,Nahori MA,Cabanes D,Gautreau A,Ait-Si-Ali S,Dessen A,Cossart P,Bierne H
R961-25 was used in ELISA, Western Blot, Immunocytochemistry to find that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs).
Fri Mar 11 00:00:00 EST 2011
The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.
The Journal of biological chemistry
Dahlbäck M,Jørgensen LM,Nielsen MA,Clausen TM,Ditlev SB,Resende M,Pinto VV,Arnot DE,Theander TG,Salanti A
R961-25 was used in ELISA to examine the binding properties of a panel of truncated VAR2CSA proteins
Fri May 06 00:00:00 EDT 2011
Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization.
The Journal of biological chemistry
Fuhs SR,Insel PA
R961-25 was used in Western Blotting to characterise the SUMOylation of caveolin-3, and elucidate its importance for the regulation of certain signalling partners.
Fri Apr 29 00:00:00 EDT 2011
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.
Nature genetics
Borg J,Papadopoulos P,Georgitsi M,Gutiérrez L,Grech G,Fanis P,Phylactides M,Verkerk AJ,van der Spek PJ,Scerri CA,Cassar W,Galdies R,van Ijcken W,Ozgür Z,Gillemans N,Hou J,Bugeja M,Grosveld FG,von Lindern M,Felice AE,Patrinos GP,Philipsen S
R961-25 was used in Western Blotting to provide a rationale for the effects of KLF1 haploinsufficiency on HbF levels.
Wed Sep 01 00:00:00 EDT 2010
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Nature immunology
Wang P,Arjona A,Zhang Y,Sultana H,Dai J,Yang L,LeBlanc PM,Doiron K,Saleh M,Fikrig E
R961-25 was used in Western Blotting to report an important role of caspase-12 in controlling viral infection via the pattern-recognition receptor RIG-I.
Fri Oct 01 00:00:00 EDT 2010
Role of lysyl oxidase propeptide in secretion and enzyme activity.
Journal of cellular biochemistry
Grimsby JL,Lucero HA,Trackman PC,Ravid K,Kagan HM
R961-25 was used in Western Blotting to point out the requirement of the LOX-PP for pro-LOX exit from the ER.
Wed Dec 01 00:00:00 EST 2010
Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo.
Radiation oncology (London, England)
Du L,Zhou LJ,Pan XJ,Wang YX,Xu QZ,Yang ZH,Wang Y,Liu XD,Zhu MX,Zhou PK
R961-25 was used in western blot to create and characterize single-chain variable antibody fragments that target DNA-dependent protein kinase catalytic subunit
Thu Aug 12 00:00:00 EDT 2010
Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
Human molecular genetics
Massinen S,Tammimies K,Tapia-Páez I,Matsson H,Hokkanen ME,Söderberg O,Landegren U,Castrén E,Gustafsson JA,Treuter E,Kere J
R961-25 was used in Western Blotting to provide insights into the function of DYX1C1 and link neuronal migration and developmental dyslexia to the oestrogen-signalling effects in the brain.
Sat Aug 01 00:00:00 EDT 2009
Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes.
Cell
Mizuguchi G,Xiao H,Wisniewski J,Smith MM,Wu C
R961-25 was used in Western Blotting to identify Scm3, a nonhistone protein that colocalises with Cse4, and is required for its centromeric association.
Fri Jun 15 00:00:00 EDT 2007
The cellulose synthase gene superfamily and biochemical functions of xylem-specific cellulose synthase-like genes in Populus trichocarpa.
Plant physiology
Suzuki S,Li L,Sun YH,Chiang VL
R961-25 was used in western blot to determine the genes and gene products involved in the synthesis of wood polysaccharides
Wed Nov 01 00:00:00 EST 2006
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.
The Journal of biological chemistry
Bhalla V,Oyster NM,Fitch AC,Wijngaarden MA,Neumann D,Schlattner U,Pearce D,Hallows KR
R961-25 was used in immunoprecipitation and western blot to examine the role of Nedd4-2 in the regulation of ENaC by AMPK
Fri Sep 08 00:00:00 EDT 2006
Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line.
Oncogene
Maeda O,Usami N,Kondo M,Takahashi M,Goto H,Shimokata K,Kusugami K,Sekido Y
R961-25 was used in Western Blotting to study whether plakoglobin has a T-cell factor/lymphocyte enhancer factor family-dependent transcriptional activity.
Thu Jan 29 00:00:00 EST 2004
Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates.
FEBS letters
Doi H,Mitsui K,Kurosawa M,Machida Y,Kuroiwa Y,Nukina N
R961-25 was used in Western Blotting to identify ubiquitin-interacting proteins in purified polyglutamine aggregates.
Fri Jul 30 00:00:00 EDT 2004
The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes.
Molecular endocrinology (Baltimore, Md.)
Gao N,Zhang J,Rao MA,Case TC,Mirosevich J,Wang Y,Jin R,Gupta A,Rennie PS,Matusik RJ
R961-25 was used in Western Blotting to identify the essential role of hepatocyte nuclear factor-3 alpha for androgen receptor-mediated prostatic gene activation.
Fri Aug 01 00:00:00 EDT 2003
Characterization of a thermophilic P-type Ag+/Cu+-ATPase from the extremophile Archaeoglobus fulgidus.
The Journal of biological chemistry
Mandal AK,Cheung WD,Argüello JM
R961-25 was used in immunohistochemistry to describe the cloning, expression, purification, and functional characterization of Archaeoglobus fulgidus CopA
Fri Mar 01 00:00:00 EST 2002
Membrane targeting of ATP-sensitive potassium channel. Effects of glycosylation on surface expression.
The Journal of biological chemistry
Conti LR,Radeke CM,Vandenberg CA
R961-25 was used in western blot to determine the relationship between the N-linked glycosylation sites (Asn(10) and Asn(1050)) and SUR1 trafficking
Fri Jul 12 00:00:00 EDT 2002
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
The Journal of biological chemistry
Holmen SL,Salic A,Zylstra CR,Kirschner MW,Williams BO
R961-25 was used in western blot to elucidate the mechanisms of Wnt signal transduction specificity in Xenopus embryos and 293T cells
Fri Sep 20 00:00:00 EDT 2002
