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VAV3 Antibody (A303-833A) in WB
Detection of human VAV3 by western blot of immunoprecipitation. Samples: Whole cell lysate (50 µg for input; 1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-VAV3 antibody A303-833A used for WB at 1 µg/ml and used for IP at 6 µg/mg lysate. VAV3 was also immunoprecipitated by rabbit anti-VAV3 antibody BL13957, which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A303-833A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 200 and 250 of Human vav 3 guanine nucleotide exchange factor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Gene Aliases: VAV3
UniProt ID: (Human) Q9UKW4
Entrez Gene ID: (Human) 10451
angiogenesis
vesicle fusion
cellular response to DNA damage stimulus
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
positive regulation of signal transduction
lamellipodium assembly
platelet activation
neutrophil chemotaxis
positive regulation of B cell proliferation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cell adhesion
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
B cell receptor signaling pathway
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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