Product References
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
Cell proliferation
Li S,Liao Z,Yin H,Liu O,Hua W,Wu X,Zhang Y,Gao Y,Yang C
Wed Mar 01 00:00:00 EST 2023
1,25(OH)2 D3 induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Cellular signalling
Erzurumlu Y,Aydogdu E,Dogan HK,Catakli D,Muhammed MT,Buyuksandic B
Wed Mar 01 00:00:00 EST 2023
CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.
Discover. Oncology
Wang C,Liu T,Wang J,Cheng C,Zhang Z,Zhang J,Huang H,Li Y
Sat Jun 03 00:00:00 EDT 2023
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling.
Journal of cell communication and signaling
Erzurumlu Y,Dogan HK,Catakli D,Aydogdu E,Muhammed MT
Fri Sep 01 00:00:00 EDT 2023
GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.
Biochimica et biophysica acta. Gene regulatory mechanisms
Almada LL,Barroso K,Sen S,Toruner M,Sigafoos AN,Raja Arul GL,Pease DR,Vera RE,Olson RLO,Auner HW,Pedeux R,Iovanna JL,Chevet E,Fernandez-Zapico ME
Thu Jun 01 00:00:00 EDT 2023
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
bioRxiv : the preprint server for biology
Tseng YJ,Malik I,Deng X,Krans A,Jansen-West K,Tank EMH,Gomez NB,Sher R,Petrucelli L,Barmada SJ,Todd PK
Wed Jun 07 00:00:00 EDT 2023
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Cellular signalling
Erzurumlu Y,Muhammed MT
Fri Sep 01 00:00:00 EDT 2023
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Steroids
Erzurumlu Y,Dogan HK,Cataklı D
Sat Jul 01 00:00:00 EDT 2023
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Molecular biology reports
Erzurumlu Y,Dogan HK,Catakli D
Wed Feb 01 00:00:00 EST 2023
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Nature communications
Ganji R,Paulo JA,Xi Y,Kline I,Zhu J,Clemen CS,Weihl CC,Purdy JG,Gygi SP,Raman M
Mon Feb 06 00:00:00 EST 2023
An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.
Cell reports
Thompson L,Depledge DP,Burgess HM,Mohr I
Tue May 03 00:00:00 EDT 2022
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Molecular & cellular proteomics : MCP
Kaokhum N,Pinto-Fernández A,Wilkinson M,Kessler BM,Ismail HM
Thu Dec 01 00:00:00 EST 2022
Valosin-containing protein (VCP/p97) is responsible for the endocytotic trafficking of classical swine fever virus.
Veterinary microbiology
Sun RC,Hu JH,Li XH,Liu CC,Liu YY,Chen J,Yang YC,Zhou B
Thu Sep 01 00:00:00 EDT 2022
Valosin-containing protein (VCP/p97) is responsible for the endocytotic trafficking of classical swine fever virus.
Veterinary microbiology
Sun RC,Hu JH,Li XH,Liu CC,Liu YY,Chen J,Yang YC,Zhou B
Thu Sep 01 00:00:00 EDT 2022
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
EMBO reports
Zheng J,Cao Y,Yang J,Jiang H
Thu Oct 06 00:00:00 EDT 2022
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.
Cell chemical biology
Read ML,Brookes K,Thornton CEM,Fletcher A,Nieto HR,Alshahrani M,Khan R,Borges de Souza P,Zha L,Webster JRM,Alderwick LJ,Campbell MJ,Boelaert K,Smith VE,McCabe CJ
Thu Mar 17 00:00:00 EDT 2022
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis.
Cell death discovery
Yi J,Wu S,Tan S,Qin Y,Wang X,Jiang J,Liu H,Wu B
Sat Dec 04 00:00:00 EST 2021
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Journal of experimental & clinical cancer research : CR
Wang Y,Zhang J,Li YJ,Yu NN,Liu WT,Liang JZ,Xu WW,Sun ZH,Li B,He QY
Fri Sep 24 00:00:00 EDT 2021
VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions.
Molecular biology of the cell
Du Y,Wang J,Xiong J,Fang N,Ji WK
Sun Aug 01 00:00:00 EDT 2021
Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection.
Nature communications
Gestuveo RJ,Royle J,Donald CL,Lamont DJ,Hutchinson EC,Merits A,Kohl A,Varjak M
Thu May 13 00:00:00 EDT 2021
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Cell death & disease
Na J,Newman JA,Then CK,Syed J,Vendrell I,Torrecilla I,Ellermann S,Ramadan K,Fischer R,Kiltie AE
Mon Feb 08 00:00:00 EST 2021
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
Experimental cell research
Zhang F,Zhou X,Zou H,Liu L,Li X,Ruan Y,Xie Y,Shi M,Xiao Y,Wang Y,Zhou Y,Wu Y,Guo B
Mon Nov 01 00:00:00 EDT 2021
Hyaluronic acid/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer.
Carbohydrate polymers
Xu R,Zhang K,Liang J,Gao F,Li J,Guan F
Tue Jun 01 00:00:00 EDT 2021
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Cell reports
Kilgas S,Singh AN,Paillas S,Then CK,Torrecilla I,Nicholson J,Browning L,Vendrell I,Konietzny R,Kessler BM,Kiltie AE,Ramadan K
Tue May 25 00:00:00 EDT 2021
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.
Cell reports
Ruggiano A,Vaz B,Kilgas S,Popović M,Rodriguez-Berriguete G,Singh AN,Higgins GS,Kiltie AE,Ramadan K
Tue Dec 07 00:00:00 EST 2021
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
ACS chemical neuroscience
Pan Y,Zhang Y,Liu N,Lu W,Yang J,Li Y,Liu Z,Wei Y,Lou Y,Kong J
Wed Apr 21 00:00:00 EDT 2021
The p97-UBXN1 complex regulates aggresome formation.
Journal of cell science
Mukkavalli S,Klickstein JA,Ortiz B,Juo P,Raman M
Thu Apr 01 00:00:00 EDT 2021
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Cell reports
Markmiller S,Fulzele A,Higgins R,Leonard M,Yeo GW,Bennett EJ
Tue Apr 30 00:00:00 EDT 2019
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Cell metabolism
Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC
Tue Apr 03 00:00:00 EDT 2018
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Cell metabolism
Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC
Tue Apr 03 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Molecular and cellular biology
Ganji R,Mukkavalli S,Somanji F,Raman M
Sun Jul 01 00:00:00 EDT 2018
Acupuncture regulates the unfolded protein response and inhibits apoptosis in a rat model of heroin relapse.
Acupuncture in medicine : journal of the British Medical Acupuncture Society
Zhang Y,Cai XH,Zhang RJ,Hou XR,Song XG,Wu SB,Yu S,Cao JP
Thu Dec 01 00:00:00 EST 2016
Acupuncture regulates the unfolded protein response and inhibits apoptosis in a rat model of heroin relapse.
Acupuncture in medicine : journal of the British Medical Acupuncture Society
Zhang Y,Cai XH,Zhang RJ,Hou XR,Song XG,Wu SB,Yu S,Cao JP
Thu Dec 01 00:00:00 EST 2016
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 EDT 2015
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 EDT 2015
Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers.
Molecular & cellular proteomics : MCP
Negroni L,Taouji S,Arma D,Pallares-Lupon N,Leong K,Beausang LA,Latterich M,Bossé R,Balabaud C,Schmitter JM,Bioulac-Sage P,Zucman-Rossi J,Rosenbaum J,Chevet E
Mon Dec 01 00:00:00 EST 2014