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Product Details
H00007415-M03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4A8
Immunogen
VCP (AAH07562, 1 a.a. approximately 588 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MVELPLRHPA LFKAIGVKPP RGILLYGPPG TGKTLIARAV ANETGAFFFL INGPEIMSKL AGESESNLRK AFEEAEKNAP AIIFIDELDA IAPKREKTHG EVERRIVSQL LTLMDGLKQR AHVIVMAATN RPNSIDPALR RFGRFDREVD IGIPDATGRL EILQIHTKNM KLADDVDLEQ VANETHGHVG ADLAALCSEA ALQAIRKKMD LIDLEDETID AEVMNSLAVT MDDFRWALSQ SNPSALRETV VEVPQVTWED IGGLEDVKRE LQELVQYPVE HPDKFLKFGM TPSKGVLFYG PPGCGKTLLA KAIANECQAN FISIKGPELL TMWFGESEAN VREIFDKARQ AAPCVLFFDE LDSIAKARGG NIGDGGGAAD RVINQILTEM DGMSTKKNVF IIGATNRPDI IDPAILRPGR LDQLIYIPLP DEKSRVAILK ANLRKSPVAK DVDLEFLAKM TNGFSGADLT EICQRACKLA IRESIESEIR RERERQTNPS AMEVEEDDPV PEIRRDHFEE AMRFARRSVS DNDIRKYEMF AQTLQQSRGF GSFRFPSGNQ GGAGPSQGSG GGTGGSVYTE DNDDDLYG
Target Information
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; epididymis luminal protein 220; epididymis secretory protein Li 70; homolog of yeast cdc48; Inv protein; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog
Gene Aliases: 3110001E05; ALS14; CDC48; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; p97/VCP; TERA; VCP
UniProt ID: (Human) P55072, (Mouse) Q01853, (Rat) P46462
Entrez Gene ID: (Human) 7415, (Mouse) 269523, (Rat) 116643
protein binding
ATP binding
lipid binding
ATPase activity
protein phosphatase binding
protein domain specific binding
polyubiquitin binding
ubiquitin protein ligase binding
deubiquitinase activator activity
K48-linked polyubiquitin binding
MHC class I protein binding
identical protein binding
ADP binding
ubiquitin-like protein ligase binding
poly(A) RNA binding
BAT3 complex binding
ubiquitin-specific protease binding
nucleotide binding
receptor binding
hydrolase activity
protein complex binding
DNA repair
double-strand break repair
ubiquitin-dependent protein catabolic process
transport
ER to Golgi vesicle-mediated transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to DNA damage stimulus
protein ubiquitination
protein N-linked glycosylation via asparagine
viral genome replication
translesion synthesis
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
positive regulation of protein complex assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein hexamerization
positive regulation of protein catabolic process
protein homooligomerization
aggresome assembly
ER-associated misfolded protein catabolic process
positive regulation of protein K63-linked deubiquitination
positive regulation of Lys63-specific deubiquitinase activity
NADH metabolic process
autophagy
positive regulation of mitochondrial membrane potential
endoplasmic reticulum unfolded protein response
ERAD pathway
regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
establishment of protein localization
ATP metabolic process
error-free translesion synthesis
flavin adenine dinucleotide catabolic process
autophagosome maturation
regulation of aerobic respiration
positive regulation of oxidative phosphorylation
positive regulation of ubiquitin-specific protease activity
positive regulation of ATP biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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