Proteintech

VDAC1/Porin Monoclonal Antibody (1E2C7)

VDAC1/Porin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

VDAC1/Porin Antibody (66345-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human heart tissue slide using (Product # 66345-1-IG) (VDAC1/Porin antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

VDAC1/Porin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

66345-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG3

Class

Monoclonal

Type

Antibody

Clone

1E2C7

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Prevotella histicola suppresses ferroptosis to mitigate ethanol-induced gastric mucosal lesions in mice.

BMC complementary medicine and therapies

Wang S,Wu D,Wu F,Sun H,Wang X,Meng H,Lin Q,Jin K,Wang F

Fri Apr 14 00:00:00 EDT 2023

DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.

Molecular medicine (Cambridge, Mass.)

Huang L,Wei B,Zhao Y,Gong X,Chen L

Tue Jun 06 00:00:00 EDT 2023

DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.

Molecular medicine (Cambridge, Mass.)

Huang L,Wei B,Zhao Y,Gong X,Chen L

Tue Jun 06 00:00:00 EDT 2023

DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1.

Molecular medicine (Cambridge, Mass.)

Huang L,Wei B,Zhao Y,Gong X,Chen L

Tue Jun 06 00:00:00 EDT 2023

Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Liang Z,Zhang N,Wang X,Zhang J,Li K,Lei T

Wed Feb 01 00:00:00 EST 2023

SYNJ2BP Improves the Production of Lentiviral Envelope Protein by Facilitating the Formation of Mitochondrion-Associated Endoplasmic Reticulum Membrane.

Journal of virology

Duan Y,Wang X,Sun K,Lin Y,Wang X,Chen K,Yang G,Wang X,Du C

Wed Oct 26 00:00:00 EDT 2022

Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.

Cell death discovery

Yan J,Sun W,Shen M,Zhang Y,Jiang M,Liu A,Ma H,Lai X,Wu J

Mon Jan 17 00:00:00 EST 2022

San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.

Journal of diabetes research

Li H,Wang Y,Su X,Wang Q,Zhang S,Sun W,Zhang T,Dong M,Zhang Z,Lv S

Mon Nov 28 00:00:00 EST 2022

San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.

Journal of diabetes research

Li H,Wang Y,Su X,Wang Q,Zhang S,Sun W,Zhang T,Dong M,Zhang Z,Lv S

Mon Nov 28 00:00:00 EST 2022

A new circular RNA-encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)-induced mitochondrial dysfunction.

The Journal of biological chemistry

Zhao X,Guo J,Wang X,Lin J,Liu Z,Xu C,Zhang D,Tong D

Thu Sep 01 00:00:00 EDT 2022

A new circular RNA-encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)-induced mitochondrial dysfunction.

The Journal of biological chemistry

Zhao X,Guo J,Wang X,Lin J,Liu Z,Xu C,Zhang D,Tong D

Thu Sep 01 00:00:00 EDT 2022

A cryostat-based frozen section method to increase the yield of extracellular vesicles extracted from different tissues.

BioTechniques

Yang S,Qin W,Li X,Guo Q,Wang Y,Chen J,Li H,Zhang S,Min L

Mon Aug 01 00:00:00 EDT 2022

The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury.

Oxidative medicine and cellular longevity

Tang W,Chai W,Du D,Xia Y,Wu Y,Jiang L,Cheng C,Guo Z,Sun X,Huang Z,Zhong J

Thu Mar 17 00:00:00 EDT 2022

PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.

Diabetes

Li C,Li L,Yang M,Yang J,Zhao C,Han Y,Zhao H,Jiang N,Wei L,Xiao Y,Liu Y,Xiong X,Xi Y,Luo S,Deng F,Chen W,Yuan S,Zhu X,Xiao L,Sun L

Sun May 01 00:00:00 EDT 2022

Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.

Journal of molecular histology

Wang F,Han J,Wang X,Liu Y,Zhang Z

Sat Oct 01 00:00:00 EDT 2022

MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients.

Frontiers in endocrinology

Yang M,Han Y,Luo S,Xiong X,Zhu X,Zhao H,Jiang N,Xiao Y,Wei L,Li C,Yang J,Sun L

Mon Dec 20 00:00:00 EST 2021

MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients.

Frontiers in endocrinology

Yang M,Han Y,Luo S,Xiong X,Zhu X,Zhao H,Jiang N,Xiao Y,Wei L,Li C,Yang J,Sun L

Mon Dec 20 00:00:00 EST 2021

PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.

International journal of molecular sciences

Li Y,Kang J,Fu J,Luo H,Liu Y,Li Y,Sun L

Wed Mar 03 00:00:00 EST 2021

The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.

Free radical biology & medicine

Li Z,Li Q,Lv W,Jiang L,Geng C,Yao X,Shi X,Liu Y,Cao J

Tue Jan 01 00:00:00 EST 2019

The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.

Free radical biology & medicine

Li Z,Li Q,Lv W,Jiang L,Geng C,Yao X,Shi X,Liu Y,Cao J

Tue Jan 01 00:00:00 EST 2019

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.

Frontiers in immunology

Liao Y,Hussain T,Liu C,Cui Y,Wang J,Yao J,Chen H,Song Y,Sabir N,Hussain M,Zhao D,Zhou X

Tue Jul 21 00:00:00 EDT 2020

Ferroptosis as a target for protection against cardiomyopathy.

Proceedings of the National Academy of Sciences of the United States of America

Fang X,Wang H,Han D,Xie E,Yang X,Wei J,Gu S,Gao F,Zhu N,Yin X,Cheng Q,Zhang P,Dai W,Chen J,Yang F,Yang HT,Linkermann A,Gu W,Min J,Wang F

Tue Feb 12 00:00:00 EST 2019

Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo.

Chemico-biological interactions

Xia X,Xiang X,Huang F,Zheng M,Zhang Z,Han L

Mon Feb 25 00:00:00 EST 2019

Bioinformatics

Protein Aliases: hVDAC1; MGC111064; Mitochondrial Porin; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; rVDAC1; VD; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5

View more View less

Gene Aliases: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5

View more View less

UniProt ID: (Human) P21796, (Mouse) Q60932, (Rat) Q9Z2L0

View more View less

Entrez Gene ID: (Human) 7416, (Mouse) 22333, (Rat) 83529

View more View less

Function(s)

protein binding voltage-gated anion channel activity porin activity protein kinase binding protein complex binding ion channel binding nucleotide binding anion channel activity voltage-gated ion channel

Process(es)

behavioral fear response anion transport mitochondrial calcium ion transport apoptotic process neuron-neuron synaptic transmission learning viral process macroautophagy epithelial cell differentiation anion transmembrane transport regulation of mitophagy regulation of anion transmembrane transport negative regulation of reactive oxygen species metabolic process transport ion transport chemical synaptic transmission regulation of anion transport transmembrane transport ion transmembrane transport regulation of ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

VDAC1/Porin Monoclonal Antibody (1E2C7)

VDAC1/Porin Antibody (66345-1-IG) in IHC (P)

Product Details

66345-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!