Invitrogen

VDAC2 Polyclonal Antibody

VDAC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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VDAC2 Antibody (PA5-28106) in IHC (P)

VDAC2 Polyclonal Antibody detects VDAC2 protein at mitochondria by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. VDAC2 stained by VDAC2 Polyclonal Antibody (Product # PA5-28106) diluted at 1:500. Antigen Retrieval: Citrat.

VDAC2 Antibody in Immunoprecipitation (IP)

VDAC2 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

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Product Details

PA5-28106

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

Immunocytochemistry (ICC/IF)

1:100-1:1,000

View 2 publications 2 publications

ELISA (ELISA)

Assay-dependent

Immunoprecipitation (IP)

1:100-1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a region within amino acids 233 and 294 of Human VDAC2

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2545582

Product Specific Information

Recommended positive controls: A549, H1299, HCT116, Mouse liver.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Toxoplasma gondii association with host mitochondria requires key mitochondrial protein import machinery.

Proceedings of the National Academy of Sciences of the United States of America

Blank ML,Xia J,Morcos MM,Sun M,Cantrell PS,Liu Y,Zeng X,Powell CJ,Yates N,Boulanger MJ,Boyle JP

PA5-28106 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that the interface between the T. gondii vacuole and the host mitochondria is characterized by interactions between a single parasite effector and multiple target host proteins, some of which are critical for the HMA phenotype itself.

Tue Mar 23 00:00:00 EDT 2021

Toxoplasma gondii association with host mitochondria requires key mitochondrial protein import machinery.

Proceedings of the National Academy of Sciences of the United States of America

Blank ML,Xia J,Morcos MM,Sun M,Cantrell PS,Liu Y,Zeng X,Powell CJ,Yates N,Boulanger MJ,Boyle JP

Tue Mar 23 00:00:00 EDT 2021

Toxoplasma gondii association with host mitochondria requires key mitochondrial protein import machinery.

Proceedings of the National Academy of Sciences of the United States of America

Blank ML,Xia J,Morcos MM,Sun M,Cantrell PS,Liu Y,Zeng X,Powell CJ,Yates N,Boulanger MJ,Boyle JP

Tue Mar 23 00:00:00 EDT 2021

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability.

Cell reports

Amen T,Kaganovich D

Published figure using VDAC2 polyclonal antibody (Product # PA5-28106) in Western Blot

Tue Jun 15 00:00:00 EDT 2021

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability.

Cell reports

Amen T,Kaganovich D

Published figure using VDAC2 polyclonal antibody (Product # PA5-28106) in Western Blot

Tue Jun 15 00:00:00 EDT 2021

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.

Nature communications

Shankar TS,Ramadurai DKA,Steinhorst K,Sommakia S,Badolia R,Thodou Krokidi A,Calder D,Navankasattusas S,Sander P,Kwon OS,Aravamudhan A,Ling J,Dendorfer A,Xie C,Kwon O,Cheng EHY,Whitehead KJ,Gudermann T,Richardson RS,Sachse FB,Schredelseker J,Spitzer KW,Chaudhuri D,Drakos SG

Published figure using VDAC2 polyclonal antibody (Product # PA5-28106) in Immunoprecipitation

Wed Jul 28 00:00:00 EDT 2021

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.

Nature communications

Published figure using VDAC2 polyclonal antibody (Product # PA5-28106) in Immunoprecipitation

Wed Jul 28 00:00:00 EDT 2021

Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.

Theranostics

Wang Z,Qin J,Zhao J,Li J,Li D,Popp M,Popp F,Alakus H,Kong B,Dong Q,Nelson PJ,Zhao Y,Bruns CJ

PA5-28106 was used in Western blotting following immunoprecipitation to demonstrate a central mechanism by which IFIT3 expression can affect chemotherapy resistance in Pancreatic ductal adenocarcinoma (PDAC).

Mon May 03 00:00:00 EDT 2021

Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.

Theranostics

Wang Z,Qin J,Zhao J,Li J,Li D,Popp M,Popp F,Alakus H,Kong B,Dong Q,Nelson PJ,Zhao Y,Bruns CJ

Mon May 03 00:00:00 EDT 2021

Bioinformatics

Protein Aliases: B36-VDAC; FLJ23841; Outer mitochondrial membrane protein porin 2; RP11-375G3.1; VDAC-2; VDAC-6; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2; Voltage-dependent anion-selective channel protein 6

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Gene Aliases: mVDAC2; mVDAC6; POR; VDAC2; Vdac6

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UniProt ID: (Human) P45880, (Mouse) Q60930, (Rat) P81155

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Entrez Gene ID: (Human) 7417, (Mouse) 22334, (Rat) 83531

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Function(s)

nucleotide binding protein binding voltage-gated anion channel activity porin activity voltage-gated ion channel

Process(es)

anion transport negative regulation of protein polymerization transmembrane transport regulation of anion transmembrane transport negative regulation of intrinsic apoptotic signaling pathway transport ion transport regulation of anion transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VDAC2 Polyclonal Antibody

VDAC2 Antibody (PA5-28106) in IHC (P)

Product Details

PA5-28106

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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