Proteintech

VEGFC Polyclonal Antibody

VEGFC Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

VEGFC Antibody (22601-1-AP) in ICC/IF

Immunofluorescent analysis of RAW 264.7 cells using 22601-1-AP (VEGFC antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

VEGFC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

22601-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VEGFC Fusion Protein Ag18182 (179-228 aa encoded by BC035212)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SYLSKTLFE ITVPLSQGPK PVTISFANHT SCRCMSKLDV YRQVHSIIRR S (179-228 aa encoded by BC035212)

Target Information

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.

Biochimica et biophysica acta. Molecular basis of disease

Bai Y,Jiao X,Hu J,Xue W,Zhou Z,Wang W

Tue Aug 01 00:00:00 EDT 2023

WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.

Biochimica et biophysica acta. Molecular basis of disease

Bai Y,Jiao X,Hu J,Xue W,Zhou Z,Wang W

Tue Aug 01 00:00:00 EDT 2023

WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.

Biochimica et biophysica acta. Molecular basis of disease

Bai Y,Jiao X,Hu J,Xue W,Zhou Z,Wang W

Tue Aug 01 00:00:00 EDT 2023

WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.

Biochimica et biophysica acta. Molecular basis of disease

Bai Y,Jiao X,Hu J,Xue W,Zhou Z,Wang W

Tue Aug 01 00:00:00 EDT 2023

PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Shang H,Xu A,Yan H,Xu D,Zhang J,Fang X

Sat Jul 01 00:00:00 EDT 2023

PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Shang H,Xu A,Yan H,Xu D,Zhang J,Fang X

Sat Jul 01 00:00:00 EDT 2023

PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Shang H,Xu A,Yan H,Xu D,Zhang J,Fang X

Sat Jul 01 00:00:00 EDT 2023

PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Shang H,Xu A,Yan H,Xu D,Zhang J,Fang X

Sat Jul 01 00:00:00 EDT 2023

Development of a method to identify persistent and blanchable redness by skin blotting in mice.

International wound journal

Nakai A,Minematsu T,Nitta S,Hsu WJ,Tobe H,Sanada H

Sat Apr 01 00:00:00 EDT 2023

Development of a method to identify persistent and blanchable redness by skin blotting in mice.

International wound journal

Nakai A,Minematsu T,Nitta S,Hsu WJ,Tobe H,Sanada H

Sat Apr 01 00:00:00 EDT 2023

Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway.

Frontiers in pharmacology

Zhou T,Yan K,Zhang Y,Zhu L,Liao Y,Zheng X,Chen Y,Li X,Liu Z,Zhang Z

Tue Jan 03 00:00:00 EST 2023

Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model.

BMC complementary medicine and therapies

Tian L,Chen X,Cao L,Zhang L,Chen J

Fri Sep 02 00:00:00 EDT 2022

Babao Dan inhibits lymphangiogenesis of gastric cancer in vitro and in vivo via lncRNA-ANRIL/VEGF-C/VEGFR-3 signaling axis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guan J,Guan B,Shang H,Peng J,Yang H,Lin J

Sat Oct 01 00:00:00 EDT 2022

The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis.

Frontiers in oncology

Xu SJ,Jin B,Zhao WJ,Chen XX,Tong YY,Ding XF,Chen YY,Wang DH,Wang ZM,Dai BQ,Chen S,Liang Y,Chen G,Pan SJ,Xu LL

Sat Jul 16 00:00:00 EDT 2022

Frontiers in oncology

Xu SJ,Jin B,Zhao WJ,Chen XX,Tong YY,Ding XF,Chen YY,Wang DH,Wang ZM,Dai BQ,Chen S,Liang Y,Chen G,Pan SJ,Xu LL

Sat Jul 16 00:00:00 EDT 2022

BANCR positively regulates the HIF-1α/VEGF-C/VEGFR-3 pathway in a hypoxic microenvironment to promote lymphangiogenesis in pancreatic cancer cells.

Oncology letters

Hao S,Han W,Ji Y,Sun H,Shi H,Ma J,Yip J,Ding Y

Thu Dec 01 00:00:00 EST 2022

Angiotensin II Induces Cardiac Edema and Hypertrophic Remodeling through Lymphatic-Dependent Mechanisms.

Oxidative medicine and cellular longevity

Bai J,Yin L,Yu WJ,Zhang YL,Lin QY,Li HH

Thu Mar 17 00:00:00 EDT 2022

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells.

Fluids and barriers of the CNS

Wang L,Mao B,Fan K,Sun R,Zhang J,Liang H,Liu Y

Thu Sep 08 00:00:00 EDT 2022

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Cells

Li H,Peng H,Hong W,Wei Y,Tian H,Huang X,Jia L,Zheng J,Duan T,He Q,Wang K

Sun Dec 25 00:00:00 EST 2022

Clostridium butyricum alleviates dextran sulfate sodium-induced experimental colitis and promotes intestinal lymphatic vessel regeneration in mice.

Annals of translational medicine

Chen X,Ma L,Liu X,Wang J,Li Y,Xie Q,Liang J

Tue Mar 01 00:00:00 EST 2022

Neurturin promotes tumor cell motility and angiogenesis in colorectal cancer.

Experimental cell research

Wang S,Nie L,Song Y,Zhang F,Chen X,Shi W,Yang Z,Sun Y,Dang Q,Gao A

Fri Apr 01 00:00:00 EDT 2022

The Hippo-TAZ axis mediates vascular endothelial growth factor C in glioblastoma-derived exosomes to promote angiogenesis.

Cancer letters

Wang Z,Yuan Y,Ji X,Xiao X,Li Z,Yi X,Zhu Y,Guo T,Wang Y,Chen L,Liu Y

Tue Aug 10 00:00:00 EDT 2021

The Hippo-TAZ axis mediates vascular endothelial growth factor C in glioblastoma-derived exosomes to promote angiogenesis.

Cancer letters

Wang Z,Yuan Y,Ji X,Xiao X,Li Z,Yi X,Zhu Y,Guo T,Wang Y,Chen L,Liu Y

Tue Aug 10 00:00:00 EDT 2021

The Hippo-TAZ axis mediates vascular endothelial growth factor C in glioblastoma-derived exosomes to promote angiogenesis.

Cancer letters

Wang Z,Yuan Y,Ji X,Xiao X,Li Z,Yi X,Zhu Y,Guo T,Wang Y,Chen L,Liu Y

Tue Aug 10 00:00:00 EDT 2021

VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.

Clinical and translational medicine

Lin QY,Zhang YL,Bai J,Liu JQ,Li HH

Mon Mar 01 00:00:00 EST 2021

Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles.

European journal of histochemistry : EJH

Cao Y,Ao DH,Ma C,Qiu WY,Zhu YC

Fri Oct 01 00:00:00 EDT 2021

Wnt Signaling Regulates the Lymphatic Endothelial Transdifferentiation of Adipose-Derived Stromal Cells In Vitro.

Cellular reprogramming

Zhang N,Hu L,Liu J,Yang W,Li Y,Pan J

Thu Apr 01 00:00:00 EDT 2021

Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.

Journal of Cancer

Shuai Y,Duan Y,Zhou M,Yue K,Liu D,Fang Y,Wang Y,Wu Y,Zhang Z,Wang X

Tue Aug 03 00:00:00 EDT 2021

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.

Journal of extracellular vesicles

Wang CA,Chang IH,Hou PC,Tai YJ,Li WN,Hsu PL,Wu SR,Chiu WT,Li CF,Shan YS,Tsai SJ

Mon Sep 28 00:00:00 EDT 2020

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.

Journal of extracellular vesicles

Wang CA,Chang IH,Hou PC,Tai YJ,Li WN,Hsu PL,Wu SR,Chiu WT,Li CF,Shan YS,Tsai SJ

Mon Sep 28 00:00:00 EDT 2020

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.

Molecular cancer

Chen Y,Wang D,Peng H,Chen X,Han X,Yu J,Wang W,Liang L,Liu Z,Zheng Y,Hu J,Yang L,Li J,Zhou H,Cui X,Li F

Fri Jan 04 00:00:00 EST 2019

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.

Molecular cancer

Chen Y,Wang D,Peng H,Chen X,Han X,Yu J,Wang W,Liang L,Liu Z,Zheng Y,Hu J,Yang L,Li J,Zhou H,Cui X,Li F

Fri Jan 04 00:00:00 EST 2019

Induced Expression of VEGFC, ANGPT, and EFNB2 and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy.

Investigative ophthalmology & visual science

Li Y,Chen D,Sun L,Wu Y,Zou Y,Liang C,Bao Y,Yi J,Zhang Y,Hou J,Li Z,Yu F,Huang Y,Yu C,Liu L,Liu Z,Zhang Y,Li Y

Tue Oct 01 00:00:00 EDT 2019

Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.

Theranostics

Zhao Z,Li L,Du P,Ma L,Zhang W,Zheng L,Lan B,Zhang B,Ma F,Xu B,Zhan Q,Song Y

Fri Jan 31 00:00:00 EST 2020

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.

Aging

Wei C,Zhang R,Cai Q,Gao X,Tong F,Dong J,Hu Y,Wu G,Dong X

Sun Sep 08 00:00:00 EDT 2019

Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression.

The American journal of pathology

Guo YC,Zhang M,Wang FX,Pei GC,Sun F,Zhang Y,He X,Wang Y,Song J,Zhu FM,Pandupuspitasari NS,Liu J,Huang K,Yang P,Xiong F,Zhang S,Yu Q,Yao Y,Wang CY

Tue Aug 01 00:00:00 EDT 2017

The American journal of pathology

Guo YC,Zhang M,Wang FX,Pei GC,Sun F,Zhang Y,He X,Wang Y,Song J,Zhu FM,Pandupuspitasari NS,Liu J,Huang K,Yang P,Xiong F,Zhang S,Yu Q,Yao Y,Wang CY

Tue Aug 01 00:00:00 EDT 2017

ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer.

PloS one

Liu L,Tong Q,Liu S,Cui J,Zhang Q,Sun W,Yang S

Mon Aug 01 00:00:00 EDT 2016

ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer.

PloS one

Liu L,Tong Q,Liu S,Cui J,Zhang Q,Sun W,Yang S

Mon Aug 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; vascular endothelial growth factor C isoform 129; vascular endothelial growth factor C isoform 184; Vascular endothelial growth factor-related protein; VEGF-C; VEGF3; VRP

View more View less

Gene Aliases: AW228853; Flt4-L; LMPH1D; VEGF-C; VEGFC; VRP

View more View less

UniProt ID: (Human) P49767, (Mouse) P97953

View more View less

Entrez Gene ID: (Human) 7424, (Mouse) 22341

View more View less

Function(s)

protein binding growth factor activity chemoattractant activity vascular endothelial growth factor receptor 3 binding growth factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

VEGFC Polyclonal Antibody

VEGFC Antibody (22601-1-AP) in ICC/IF

Product Details

22601-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!