Proteintech

VEGFR-1/FLT-1 Polyclonal Antibody

VEGFR-1/FLT-1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

VEGFR-1/FLT-1 Antibody (13687-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 13687-1-AP (VEGFR-1/FLT-1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

VEGFR-1/FLT-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

VEGFR-1/FLT-1 Antibody in Western Blot (WB)

VEGFR-1/FLT-1 Antibody in Flow Cytometry (Flow)

VEGFR-1/FLT-1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13687-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Deer, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VEGFR-1/FLT-1 Fusion Protein Ag4558 (21-300 aa encoded by BC039007)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TGSSSGSKL KDPELSLKGT QHIMQAGQTL HLQCRGEAAH KWSLPEMVSK ESERLSITKS ACGRNGKQFC STLTLNTAQA NHTGFYSCKY LAVPTSKKKE TESAIYIFIS DTGRPFVEMY SEIPEIIHMT EGRELVIPCR VTSPNITVTL KKFPLDTLIP DGKRIIWDSR KGFIISNATY KEIGLLTCEA TVNGHLYKTN YLTHRQTNTI IDVQISTPRP VKLLRGHTLV LNCTATTPLN TRVQMTWSYP DEKNKRASVR RRIDQSNSHA NIFYSVLTID K (21-300 aa encoded by BC039007)

Target Information

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Embryonic receptor kinase 2; FLT; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; Vascular permeability factor receptor; VEGF R1; VEGFR-1

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Gene Aliases: AI323757; Emrk2; FLT; FLT-1; FLT1; FRT; sFlt1; VEGFR-1; VEGFR1

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UniProt ID: (Human) P17948, (Mouse) P35969

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Entrez Gene ID: (Human) 2321, (Mouse) 14254, (Rat) 54251

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Function(s)

transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups identical protein binding receptor signaling protein tyrosine kinase activity transmembrane signal receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VEGFR-1/FLT-1 Polyclonal Antibody

VEGFR-1/FLT-1 Antibody (13687-1-AP) in ICC/IF

Product Details

13687-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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