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VGF Antibody (PA5-106693) in IHC (P)
Immunohistochemistry analysis of VGF in rat kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with VGF polyclonal antibody (Product # PA5-106693) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106693
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human VGF(Accession O15240), corresponding to amino acid residues I452-H502.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854361
Product Specific Information
Antibody detects endogenous levels of total VGF.
Target Information
VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuro-endocrine specific protein VGF; Neurosecretory protein VGF; VGF8a protein
Gene Aliases: Gm1052; SCG7; SgVII; VGF
UniProt ID: (Human) O15240, (Rat) P20156, (Mouse) Q0VGU4
Entrez Gene ID: (Human) 7425, (Rat) 29461, (Mouse) 381677
ovarian follicle development
response to dietary excess
generation of precursor metabolites and energy
response to cold
sexual reproduction
insulin secretion
response to insulin
carbohydrate homeostasis
glucose homeostasis
defense response to bacterium
regulation of synaptic plasticity
response to cAMP
neuron differentiation
penile erection
regulation of neuronal synaptic plasticity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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