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Product Details
H00007429-M26
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2F10
Immunogen
VIL1 (AAH17303, 1 a.a. approximately 421 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MTKLSAQVKG SLNITTPGLQ IWRIEAMQMV PVPSSTFGSF FDGDCYIILA IHKTASSLSY DIHYWIGQDS SLDEQGAAAI YTTQMDDFLK GRAVQHREVQ GNESEAFRGY FKQGLVIRKG GVASGMKHVE TNSYDVQRLL HVKGKRNVVA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP ESTRMERLRG MTLAKEIRDQ ERGGRTYVGV VDGENELASP KLMEVMNHVL GKRRELKAAV PDTVVEPALK AALKLYHVSD SEGNLVVREV ATRPLTQDLL SHEDCYILDQ GGLKIYVWKG KKANEQEKKG AMSHALNFIK AKQYPPSTQV EVQNDGAESA VFQQLFQKWT ASNRTSGLGK THTVGSVGEG QAGAVREPGS RSWARRATWS TTHPPSLTCI FNEDFYAGSG LVLADGDVDK L
Target Information
Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000207159; Villin-1
Gene Aliases: D2S1471; VIL; VIL1
UniProt ID: (Human) P09327
Entrez Gene ID: (Human) 7429
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
lysophosphatidic acid binding
identical protein binding
protein homodimerization activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
actin filament binding
non-motor actin binding protein
intestinal D-glucose absorption
protein complex assembly
apoptotic process
epidermal growth factor receptor signaling pathway
regulation of cell shape
response to bacterium
positive regulation of epithelial cell migration
actin filament polymerization
actin filament depolymerization
positive regulation of cell migration
positive regulation of actin filament depolymerization
epithelial cell differentiation
positive regulation of actin filament bundle assembly
regulation of microvillus length
cellular response to hepatocyte growth factor stimulus
positive regulation of multicellular organism growth
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
actin nucleation
actin filament severing
barbed-end actin filament capping
regulation of actin nucleation
actin filament capping
cytoplasmic actin-based contraction involved in cell motility
regulation of wound healing
cellular response to epidermal growth factor stimulus
positive regulation of establishment of protein localization to plasma membrane
terminal web assembly
regulation of lamellipodium morphogenesis
positive regulation of lamellipodium morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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