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FIGURE: 1 / 1
VNN2 Antibody (PA5-96960) in WB
Western blot analysis of VNN2 in extracts of various cell lines. Samples were incubated with VNN2 Polyclonal antibody (Product # PA5-96960) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96960
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 270-493 of human VNN2 (NP_0046562)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808762
Product Specific Information
Immunogen sequence: VSLNMTGSGI YAPNGPKVYH YDMKTELGKL LLSEVDSHPL SSLAYPTAVN WNAYATTIKP FPVQKNTFRG FISRDGFNFT ELFENAGNLT VCQKELCCHL SYRMLQKEEN EVYVLGAFTG LHGRRRREYW QVCTMLKCKT TNLTTCGRPV ETASTRFEMF SLSGTFGTEY VFPEVLLTEI HLSPGKFEVL KDGRLVNKNG SSGPILTVSL FGRWYTKDSL YSSC; Positive Samples: Raji, Mouse brain, Rat brain; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor
Target Information
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycosylphosphatidyl inositol-anchored protein GPI-80; pantetheinase; Pantetheine hydrolase VNN2; Protein FOAP-4; Vanin-2; Vannin 2; Vascular non-inflammatory molecule 2
Gene Aliases: FOAP-4; GPI-80; VNN2
UniProt ID: (Human) O95498
Entrez Gene ID: (Human) 8875
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