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Product Details
17894-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VPS15 Fusion Protein Ag12221 (1-330 aa encoded by BC110318)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNQLAGIA PSQILSVESY FSDIHDFEYD KSLGSTRFFK VARAKHREGL VVVKVFAIQD PTLPLTSYKQ ELEELKIRLN SAQNCLPFQK ASEKASEKAA MLFRQYVRDN LYDRISTRPF LNNIEKRWIA FQILTAVDQA HKSGVRHGDI KTENVMVTSW NWVLLTDFAS FKPTYLPEDN PADFNYFFDT SRRRTCYIAP ERFVDGGMFA TELEYMRDPS TPLVDLNSNQ RTRGELKRAM DIFSAGCVIA ELFTEGVPLF DLSQLLAYRN GHFFPEQVLN KIEDHSIREL VTQMIHREPD KRLEAEDYLK QQRGNAFPEI FYTFLQPYMA Q (1-330 aa encoded by BC110318)
Target Information
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-Kinase p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3-kinase VPS15
Gene Aliases: 2210010O15Rik; C730038E05Rik; C85833; D9Ertd418e; p150; PIK3R4; VPS15
UniProt ID: (Human) Q99570, (Rat) P0C0R5, (Mouse) Q8VD65
Entrez Gene ID: (Human) 30849, (Rat) 363131, (Mouse) 75669
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
molecular_function
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase modulator
protein-binding activity modulator
protein phosphorylation
protein targeting to vacuole
phosphatidylinositol biosynthetic process
macroautophagy
pexophagy
regulation of cytokinesis
receptor catabolic process
toll-like receptor 9 signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
cellular response to glucose starvation
positive regulation of phosphatidylinositol 3-kinase activity
late endosome to vacuole transport
biological_process
phosphorylation
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