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VPS33B Antibody (BS-12771R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with VPS33B Polyclonal Antibody, Unconjugated (bs-12771R) at 1:400 overnight at 4°C, DAB staining.
Product Details
BS-12771R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human VPS33B, amino acids 361-460.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ14848; hVPS33B; r-vps33b; vacuolar protein sorting 33 homolog B; vacuolar protein sorting 33-like protein B; vacuolar protein sorting 33B; vacuolar protein sorting homolog r-vps33b; Vacuolar protein sorting-associated protein 33B
Gene Aliases: VPS33B
UniProt ID: (Human) Q9H267, (Mouse) P59016, (Rat) Q63616
Entrez Gene ID: (Human) 26276, (Mouse) 233405, (Rat) 64060
vesicle docking involved in exocytosis
endosome organization
endosome to lysosome transport
protein transport
vesicle-mediated transport
melanosome localization
lysosome localization
megakaryocyte development
membrane fusion
platelet alpha granule organization
regulation of platelet aggregation
autophagosome maturation
transport
biological_process
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