Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: ESCEEKNQL ILTASADRTV IVWDGDTTRQ VQRISCFQST VKCLTVLQRL DVWLSGGNDL CVWNRKLDLL CKTSHLSDTG ISALVEIPKN CVVAAVGKEL IIFRLVAPTE GSLEWDILEV KRLLDHQDNI LSLINVNDLS FVTGSHVGEL IIWDALDWTM QAYERNFWDP SPQLDTQQEI KLCQKSNDIS IHHFTCDEEN VFAAVGRGLY VYSLQMKRVI ACQKTAHDSN VLHVARLPNR QLISCSEDGS VRIWELREKQ QLAAEPVPTG FFNMWGFGRV SKQASQPVKK QQENATSCSL ELIGDLIGHS SSVEMFLYFE DHGLVTCSAD HLIILWKNGE RESGLRSLRL FQKLEENGDL YLAV (97-459 aa encoded by BC040241)
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: WD repeat-containing protein 41
Gene Aliases: MSTP048; WDR41
UniProt ID: (Human) Q9HAD4
Entrez Gene ID: (Human) 55255
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