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Product Details
PA5-37320
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length human Wnt3a
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2554007
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 39 and 68 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Wnt3a, part of the WNT gene family, consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC119418; MGC119419; MGC119420; Protein Wnt-3a; vestigial tail; wingless-related MMTV integration site 3A; wingless-type MMTV integration site family member 3A; wingless-type MMTV integration site family, member 3A; Wnt 3a; WNT3A protein
Gene Aliases: vt; Wnt-3a; WNT3A
UniProt ID: (Human) P56704, (Mouse) P27467
Entrez Gene ID: (Human) 89780, (Rat) 303181, (Mouse) 22416
osteoblast differentiation
in utero embryonic development
positive regulation of cytokine production
positive regulation of protein phosphorylation
heart looping
positive regulation of receptor internalization
negative regulation of heart induction by canonical Wnt signaling pathway
axon guidance
synapse assembly
positive regulation of cell proliferation
COP9 signalosome assembly
negative regulation of neuron projection development
Wnt signaling pathway
spinal cord association neuron differentiation
hippocampus development
cell proliferation in forebrain
Wnt signaling pathway involved in forebrain neuroblast division
dorsal/ventral neural tube patterning
hemopoiesis
neuron differentiation
extracellular matrix organization
mammary gland development
positive regulation of B cell proliferation
positive regulation of protein binding
positive regulation of peptidyl-serine phosphorylation
cell proliferation in midbrain
cellular protein localization
positive regulation of catenin import into nucleus
skeletal muscle cell differentiation
post-anal tail morphogenesis
synaptic vesicle recycling
inner ear morphogenesis
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mesodermal cell fate specification
paraxial mesodermal cell fate commitment
positive regulation of skeletal muscle tissue development
positive regulation of collateral sprouting in absence of injury
negative regulation of axon extension involved in axon guidance
negative regulation of neurogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
canonical Wnt signaling pathway
positive regulation of protein tyrosine kinase activity
positive regulation of dermatome development
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
regulation of microtubule cytoskeleton organization
platelet aggregation
cellular response to retinoic acid
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to plasma membrane
negative regulation of dopaminergic neuron differentiation
beta-catenin destruction complex disassembly
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
positive regulation of neural precursor cell proliferation
positive regulation of hepatocyte proliferation
positive regulation of transcription regulatory region DNA binding
positive regulation of cardiac muscle cell differentiation
somitogenesis
determination of left/right symmetry
axonogenesis
mesoderm development
biological_process
anterior/posterior pattern specification
platelet activation
cell fate commitment
regulation of cell differentiation
somatic stem cell division
regulation of axonogenesis
cardiac muscle cell fate commitment
signal transduction
cell-cell signaling
multicellular organism development
organ morphogenesis
BMP signaling pathway
positive regulation of receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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