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Product Details
H00007508-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6D11
Immunogen
XPC (NP_004619, 141 a.a. approximately 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: EPVLGDVRES TAFSRSLLPV KPVEIEIETP EQAKTRERSE KIKLEFETYL RRAMKRFNKG VHEDTHKVHL LCLLANGFYR NNICSQPDLH AIGLSIIPAR FTRVLPRDVD
Target Information
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; NER; p125; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C
Gene Aliases: p125; RAD4; XP3; XPC; XPCC
UniProt ID: (Human) Q01831
Entrez Gene ID: (Human) 7508
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
DNA repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
mismatch repair
response to UV-B
response to auditory stimulus
protein sumoylation
intra-S DNA damage checkpoint
response to drug
global genome nucleotide-excision repair
UV-damage excision repair
regulation of mitotic cell cycle phase transition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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