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XRCC5/Ku80 Polyclonal Antibody

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Antibody Testing Data (15)

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

XRCC5/Ku80 Antibody (16389-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using XRCC5 antibody 16389-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF)

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Western Blot (WB)

XRCC5/Ku80 Antibody in Immunoprecipitation (IP)

Product Image Gallery

XRCC5/Ku80 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using XRCC5 antibody 16389-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 10x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 16389-1-AP (XRCC5/Ku80 antibody at dilution of 1:50 (under 10x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:100 (under 40x lens).

XRCC5/Ku80 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:100 (under 10x lens).

XRCC5/Ku80 Antibody in Western Blot (WB) — Human liver tissue were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — A431 cells were subjected to SDS PAGE followed by western blot with 16389-1-AP (XRCC5/Ku80 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

XRCC5/Ku80 Antibody in Western Blot (WB) — WB result of Ku80 antibody (16389-1-AP, 1:4000) with si-Control and si-Ku80 transfected HEK-293 cells.

XRCC5/Ku80 Antibody in Immunoprecipitation (IP) — IP result of anti-XRCC5/Ku80 (IP:16389-1-AP, 4ug; Detection:16389-1-AP 1:1000) with HEK-293 cells lysate 1200ug.

Product Details

16389-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 6 publications 6 publications

ChIP assay (ChIP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XRCC5/Ku80 Fusion Protein Ag9454

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

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Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

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Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

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Chen M,Zhao E,Li M,Xu M,Hao S,Gao Y,Wu X,Li X,Yu Y,Yu Z,Yin Y

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Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

Phytomedicine : international journal of phytotherapy and phytopharmacology

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Tue Jul 25 00:00:00 EDT 2023

Kaempferol inhibits non-homologous end joining repair via regulating Ku80 stability in glioma cancer.

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Clinical and translational science

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Cell reports

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Thu Feb 10 00:00:00 EST 2022

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Thu Feb 10 00:00:00 EST 2022

Proteomic Analysis of Vero Cells Infected with Pseudorabies Virus.

Viruses

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Thu Oct 01 00:00:00 EDT 2020

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Tue Apr 25 00:00:00 EDT 2017

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Oncotarget

Qi H,Jiang Z,Wang C,Yang Y,Li L,He H,Yu Z

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Bioinformatics

Protein Aliases: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku autoantigen protein p86 homolog; Ku autoantigen, 80kDa; Ku p80; Ku-80; Ku-86; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupu; lupus; Lupus Ku autoantigen protein p86; Nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5

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Gene Aliases: AI314015; G22P2; KARP-1; KARP1; KU80; Ku86; KUB2; NFIV; XRCC5

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UniProt ID: (Human) P13010, (Mouse) P27641

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Entrez Gene ID: (Human) 7520, (Mouse) 22596

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DNA binding damaged DNA binding double-stranded DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity protein binding ATP binding protein C-terminus binding ubiquitin protein ligase binding telomeric DNA binding transcription regulatory region DNA binding poly(A) RNA binding macromolecular complex binding 5'-deoxyribose-5-phosphate lyase activity nucleotide binding helicase activity hydrolase activity hydrolase activity, acting on acid anhydrides DNA helicase

Process(es)

telomere maintenance double-strand break repair double-strand break repair via nonhomologous end joining DNA recombination transcription, DNA-templated cell proliferation positive regulation of type I interferon production DNA duplex unwinding negative regulation of transcription, DNA-templated regulation of smooth muscle cell proliferation positive regulation of neurogenesis hematopoietic stem cell differentiation cellular response to gamma radiation cellular response to X-ray establishment of integrated proviral latency negative regulation of t-circle formation DNA repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus cellular hyperosmotic salinity response

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