Proteintech

XRN2 Polyclonal Antibody

FIGURE: 1 / 5

XRN2 Antibody (11267-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 11267-1-AP) (XRN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

11267-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

View 2 publications 2 publications

ChIP assay (ChIP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XRN2 Fusion Protein Ag1788 (651-950 aa encoded by BC006417)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PFVDERRLR AALEEVYPDL TPEETRRNSL GGDVLFVGKH HPLHDFILEL YQTGSTEPVE VPPELCHGIQ GKFSLDEEAI LPDQIVCSPV PMLRDLTQNT VVSINFKDPQ FAEDYIFKAV MLPGARKPAA VLKPSDWEKS SNGRQWKPQL GFNRDRRPVH LDQAAFRTLG HVMPRGSGTG IYSNAAPPPV TYQGNLYRPL LRGQAQIPKL MSNMRPQDSW RGPPPLFQQQ RFDRGVGAEP LLPWNRMLQT QNAAFQPNQY QMLAGPGGYP PRRDDRGGRQ GYPREGRKYP LPPPSGRYNW N (651-950 aa encoded by BC006417)

Target Information

XRN2 gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Nature

Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV

Wed Jun 01 00:00:00 EDT 2022

R-Loop Immunoprecipitation: A Method to Detect R-Loop Interacting Factors.

Methods in molecular biology (Clifton, N.J.)

Beghè C,Gromak N

Fri Jun 17 00:00:00 EDT 2022

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.

The EMBO journal

Mersaoui SY,Yu Z,Coulombe Y,Karam M,Busatto FF,Masson JY,Richard S

Thu Aug 01 00:00:00 EDT 2019

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.

The EMBO journal

Mersaoui SY,Yu Z,Coulombe Y,Karam M,Busatto FF,Masson JY,Richard S

Thu Aug 01 00:00:00 EDT 2019

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.

The EMBO journal

Mersaoui SY,Yu Z,Coulombe Y,Karam M,Busatto FF,Masson JY,Richard S

Thu Aug 01 00:00:00 EDT 2019

Intronless mRNAs transit through nuclear speckles to gain export competence.

The Journal of cell biology

Wang K,Wang L,Wang J,Chen S,Shi M,Cheng H

Mon Nov 05 00:00:00 EST 2018

Characterization of miR-122-independent propagation of HCV.

PLoS pathogens

Ono C,Fukuhara T,Motooka D,Nakamura S,Okuzaki D,Yamamoto S,Tamura T,Mori H,Sato A,Uemura K,Fauzyah Y,Kurihara T,Suda T,Nishio A,Hmwe SS,Okamoto T,Tatsumi T,Takehara T,Chayama K,Wakita T,Koike K,Matsuura Y

Mon May 01 00:00:00 EDT 2017

Characterization of miR-122-independent propagation of HCV.

PLoS pathogens

Mon May 01 00:00:00 EDT 2017

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Journal of virology

Li Y,Yamane D,Lemon SM

Fri May 01 00:00:00 EDT 2015

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Journal of virology

Li Y,Yamane D,Lemon SM

Fri May 01 00:00:00 EDT 2015

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Journal of virology

Li Y,Yamane D,Lemon SM

Fri May 01 00:00:00 EDT 2015

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Journal of virology

Li Y,Yamane D,Lemon SM

Fri May 01 00:00:00 EDT 2015

Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.

Cell

Wagschal A,Rousset E,Basavarajaiah P,Contreras X,Harwig A,Laurent-Chabalier S,Nakamura M,Chen X,Zhang K,Meziane O,Boyer F,Parrinello H,Berkhout B,Terzian C,Benkirane M,Kiernan R

Fri Sep 14 00:00:00 EDT 2012

Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.

Cell

Wagschal A,Rousset E,Basavarajaiah P,Contreras X,Harwig A,Laurent-Chabalier S,Nakamura M,Chen X,Zhang K,Meziane O,Boyer F,Parrinello H,Berkhout B,Terzian C,Benkirane M,Kiernan R

Fri Sep 14 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein; XRN2b

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Gene Aliases: XRN2

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UniProt ID: (Human) Q9H0D6

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Entrez Gene ID: (Human) 22803

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Function(s)

3'-5'-exoribonuclease activity transcription termination site sequence-specific DNA binding nuclease activity 5'-3' exoribonuclease activity protein binding 5'-3' exonuclease activity poly(A) RNA binding metal ion binding exoribonuclease

Process(es)

DNA catabolic process, exonucleolytic DNA-templated transcription, termination regulation of transcription, DNA-templated rRNA processing RNA processing mRNA processing RNA catabolic process spermatogenesis cell growth RNA metabolic process RNA phosphodiester bond hydrolysis, exonucleolytic

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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XRN2 Polyclonal Antibody

XRN2 Antibody (11267-1-AP) in WB

Product Details

11267-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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