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Product Details
CF809427
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI5F4
Immunogen
Human recombinant protein fragment corresponding to amino acids 677-779 of human XRN2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
XRN2 gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein; Protein Dhm1; XRN2b
Gene Aliases: Dhm1; XRN2
UniProt ID: (Human) Q9H0D6, (Mouse) Q9DBR1
Entrez Gene ID: (Human) 22803, (Mouse) 24128, (Rat) 362229
3'-5'-exoribonuclease activity
transcription termination site sequence-specific DNA binding
nuclease activity
5'-3' exoribonuclease activity
protein binding
5'-3' exonuclease activity
poly(A) RNA binding
metal ion binding
nucleic acid binding
DNA binding
exonuclease activity
zinc ion binding
hydrolase activity
molecular_function
exoribonuclease
DNA catabolic process, exonucleolytic
DNA-templated transcription, termination
regulation of transcription, DNA-templated
rRNA processing
RNA processing
mRNA processing
RNA catabolic process
spermatogenesis
cell growth
RNA metabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
nucleobase-containing compound metabolic process
DNA repair
DNA recombination
transcription, DNA-templated
microtubule-based process
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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