Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL FNSVVNVGCG PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY KEGKYIIELN HMIKDNGWD; Positive Samples: Rat spleen; Cellular Location: Nucleus, nucleolus
YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.
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Protein Aliases: Protein yippee-like 3; Small ubiquitinated apoptotic protein
Gene Aliases: 0610043B10Rik; 1190001G19Rik; RGD1564579; Suap; Ypel3
UniProt ID: (Mouse) P61237
Entrez Gene ID: (Mouse) 66090, (Rat) 293491
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