Proteintech

YWHAZ Polyclonal Antibody

FIGURE: 1 / 1

YWHAZ Antibody (14881-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 14881-1-AP (YWHAZ antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

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Product Details

14881-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

Assay-dependent

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

YWHAZ Fusion Protein Ag6654 (1-245 aa encoded by BC003623)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody was raised against the full-length YWHAZ.

Immunogen sequence: MDKNELVQK AKLAEQAERY DDMAACMKSV TEQGAELSNE ERNLLSVAYK NVVGARRSSW RVVSSIEQKT EGAEKKQQMA REYREKIETE LRDICNDVLS LLEKFLIPNA SQAESKVFYL KMKGDYYRYL AEVAAGDDKK GIVDQSQQAY QEAFEISKKE MQPTHPIRLG LALNFSVFYY EILNSPEKAC SLAKTAFDEA IAELDTLSEE SYKDSTLIMQ LLRDNLTLWT SDTQGDEAEA GEGGEN (1-245 aa encoded by B C003623)

Target Information

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting.

Molecular cell

Zhao Y,Li S,Chen Y,Wang Y,Wei Y,Zhou T,Zhang Y,Yang Y,Chen L,Liu Y,Hu C,Zhou B,Ding Q

Thu Apr 06 00:00:00 EDT 2023

Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.

Haematologica

Michalik S,Siegerist F,Palankar R,Franzke K,Schindler M,Reder A,Seifert U,Cammann C,Wesche J,Steil L,Hentschker C,Gesell-Salazar M,Reisinger E,Beer M,Endlich N,Greinacher A,Völker U

Fri Apr 01 00:00:00 EDT 2022

Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.

Molecular cell

Zhang Z,Chen C,Yang F,Zeng YX,Sun P,Liu P,Li X

Thu Aug 04 00:00:00 EDT 2022

Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling.

World journal of gastrointestinal oncology

Zheng W,Shen GL,Xu KY,Yin QQ,Hui TC,Zhou ZW,Xu CA,Wang SH,Wu WH,Shi LF,Pan HY

Sat Jan 15 00:00:00 EST 2022

GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.

Cell communication and signaling : CCS

Zhou F,Liu Y,Ai W,Wang Y,Gan M,Jiang Q,Han T,Wang JB

Tue Aug 30 00:00:00 EDT 2022

AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.

The EMBO journal

Zheng X,Xiao J,Jiang Q,Zheng L,Liu C,Dong C,Zheng Y,Ni P,Zhang C,Zhang F,Zhong R,Ding H,Wang Q,Qiu Y,Gao M,Ding J,Shen N,Wei B,Wang H

Tue Mar 15 00:00:00 EDT 2022

YWHAZ interacts with DAAM1 to promote cell migration in breast cancer.

Cell death discovery

Mei J,Liu Y,Yu X,Hao L,Ma T,Zhan Q,Zhang Y,Zhu Y

Fri Aug 27 00:00:00 EDT 2021

YWHAZ interacts with DAAM1 to promote cell migration in breast cancer.

Cell death discovery

Mei J,Liu Y,Yu X,Hao L,Ma T,Zhan Q,Zhang Y,Zhu Y

Fri Aug 27 00:00:00 EDT 2021

High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Sajic M,Rumora AE,Kanhai AA,Dentoni G,Varatharajah S,Casey C,Brown RDR,Peters F,Hinder LM,Savelieff MG,Feldman EL,Smith KJ

Wed May 12 00:00:00 EDT 2021

YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.

International journal of biological sciences

Zhang T,Beeharry MK,Wang Z,Zhu Z,Li J,Li C

Wed Mar 30 00:00:00 EDT 2022

1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.

Biochemical pharmacology

Zhou Y,Fu X,Guan Y,Gong M,He K,Huang B

Sat Feb 01 00:00:00 EST 2020

Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes.

Disease models & mechanisms

O'Brien PD,Guo K,Eid SA,Rumora AE,Hinder LM,Hayes JM,Mendelson FE,Hur J,Feldman EL

Fri Jan 24 00:00:00 EST 2020

The ASH1-miR-375-YWHAZ Signaling Axis Regulates Tumor Properties in Hepatocellular Carcinoma.

Molecular therapy. Nucleic acids

Zhao JF,Zhao Q,Hu H,Liao JZ,Lin JS,Xia C,Chang Y,Liu J,Guo AY,He XX

Fri Jun 01 00:00:00 EDT 2018

The ASH1-miR-375-YWHAZ Signaling Axis Regulates Tumor Properties in Hepatocellular Carcinoma.

Molecular therapy. Nucleic acids

Zhao JF,Zhao Q,Hu H,Liao JZ,Lin JS,Xia C,Chang Y,Liu J,Guo AY,He XX

Fri Jun 01 00:00:00 EDT 2018

The ASH1-miR-375-YWHAZ Signaling Axis Regulates Tumor Properties in Hepatocellular Carcinoma.

Molecular therapy. Nucleic acids

Zhao JF,Zhao Q,Hu H,Liao JZ,Lin JS,Xia C,Chang Y,Liu J,Guo AY,He XX

Fri Jun 01 00:00:00 EDT 2018

The ASH1-miR-375-YWHAZ Signaling Axis Regulates Tumor Properties in Hepatocellular Carcinoma.

Molecular therapy. Nucleic acids

Zhao JF,Zhao Q,Hu H,Liao JZ,Lin JS,Xia C,Chang Y,Liu J,Guo AY,He XX

Fri Jun 01 00:00:00 EDT 2018

YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated Osteosarcoma Cell Proliferation.

Biomedical and environmental sciences : BES