Proteintech

YY1 Polyclonal Antibody

YY1 Antibody in Immunocytochemistry (ICC/IF)

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YY1 Antibody (22156-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 22156-1-AP) (YY1 antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

YY1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

YY1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22156-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

ChIP assay (ChIP)

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

YY1 Fusion Protein Ag17792 (1-414 aa encoded by BC037308)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The open reading frame of the human YY1 cDNA encodes a protein of 414 amino acids with a predicted molecular weight of 44 kDa. However, YY1 migrates on SDS gels as a 65-68 kDa protein, probably due to the structure of the protein. It is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis, differentiation, replication, and proliferation. This is a rabbit polyclonal antibody raised against full length YY1 of human origin.

Immunogen sequence: MASGDTLYI ATDGSEMPAE IVELHEIEVE TIPVETIETT VVGEEEEEDD DDEDGGGGDH GGGGGHGHAG HHHHHHHHHH HPPMIALQPL VTDDPTQVHH HQEVILVQTR EEVVGGDDSD GLRAEDGFED QILIPVPAPA GGDDDYIEQT LVTVAAAGKS GGGGSSSSGG GRVKKGGGKK SGKKSYLSGG AGAAGGGGAD PGNKKWEQKQ VQIKTLEGEF SVTMWSSDEK KDIDHETVVE EQIIGENSPP DYSEYMTGKK LPPGGIPGID LSDPKQLAEF ARMKPRKIKE DDAPRTIACP HKGCTKMFRD NSAMRKHLHT HGPRVHVCAE CGKAFVESSK LKRHQLVHTG EKPFQCTFEG CGKRFSLDFN LRTHVRIHTG DRPYVCPFDG CNKKFAQSTN LKSHILTHAK AKNNQ (1-414 aa encoded by BC037308)

Target Information

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Yang T,Wang Y,Cao X,Peng Y,Huang J,Chen L,Pang J,Jiang Z,Qian S,Liu Y,Ying C,Wang T,Zhang F,Lu Q,Yin X

Mon May 01 00:00:00 EDT 2023

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Cellular oncology (Dordrecht)

Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B

Tue Aug 01 00:00:00 EDT 2023

RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Cellular oncology (Dordrecht)

Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B

Tue Aug 01 00:00:00 EDT 2023

Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.

Pathology international

Wang QD,Liu LL,Li D,Gao L,Zhang MJ

Wed Mar 01 00:00:00 EST 2023

Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.

Pathology international

Wang QD,Liu LL,Li D,Gao L,Zhang MJ

Wed Mar 01 00:00:00 EST 2023

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Cell & bioscience

Si M,Song Y,Wang X,Wang D,Liu X,Qu X,Song Z,Yu X

Sun Oct 09 00:00:00 EDT 2022

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Cell & bioscience

Si M,Song Y,Wang X,Wang D,Liu X,Qu X,Song Z,Yu X

Sun Oct 09 00:00:00 EDT 2022

Dynamic control of chromatin-associated m⁶A methylation regulates nascent RNA synthesis.

Molecular cell

Xu W,He C,Kaye EG,Li J,Mu M,Nelson GM,Dong L,Wang J,Wu F,Shi YG,Adelman K,Lan F,Shi Y,Shen H

Thu Mar 17 00:00:00 EDT 2022

HPV8 Reverses the Transcriptional Output in Lrig1 Positive Cells to Drive Skin Tumorigenesis.

Cancers

Syed AS,Marcuzzi GP,Miller-Lazic D,Hess J,Hufbauer M,Akgül B

Fri Mar 25 00:00:00 EDT 2022

MORTALIN-Ca²⁺ axis drives innate rituximab resistance in diffuse large B-cell lymphoma.

Cancer letters

Sun Q,Ye Y,Gui A,Sun X,Xie S,Zhan Y,Chen R,Yan Y,Gu J,Qiu S,Liu W,Zuo J,Zhang Q,Yang L

Fri Jul 01 00:00:00 EDT 2022

Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.

Life sciences

Teafatiller T,Subramanian S,Marquez FE,Kitazawa M,Subramanian VS

Tue Nov 01 00:00:00 EDT 2022

Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration.

Frontiers in cellular and infection microbiology

Wang J,Liu Z,Xu Y,Wang Y,Wang F,Zhang Q,Ni C,Zhen Y,Xu R,Liu Q,Fang W,Huang P,Liu X

Mon Aug 15 00:00:00 EDT 2022

Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development.

Molecules (Basel, Switzerland)

Zhao H,Dong Y,Zhang Y,Wu X,Zhang X,Liang Y,Li Y,Zeng F,Shi J,Zhou R,Hong L,Cai G,Wu Z,Li Z

Wed Oct 12 00:00:00 EDT 2022

Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development.

Molecules (Basel, Switzerland)

Zhao H,Dong Y,Zhang Y,Wu X,Zhang X,Liang Y,Li Y,Zeng F,Shi J,Zhou R,Hong L,Cai G,Wu Z,Li Z

Wed Oct 12 00:00:00 EDT 2022

Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.

Journal of neuroinflammation

Gao C,Jia W,Xu W,Wu Q,Wu J

Sat May 22 00:00:00 EDT 2021

PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma via Modulation of EphA2 Expression.

Frontiers in oncology

Han X,Zhu Y,Shen L,Zhou Y,Pang L,Zhou W,Gu H,Han K,Yang Y,Jiang C,Xie J,Zhang C,Ding L

Sat Apr 10 00:00:00 EDT 2021

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.

Theranostics

Zhang C,Shen L,Zhu Y,Xu R,Deng Z,Liu X,Ding Y,Wang C,Shi Y,Bei L,Wei D,Thorne RF,Zhang XD,Yu L,Chen S

Tue Jul 27 00:00:00 EDT 2021

Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries.

Cell death & disease

Zhou M,Liu X,Qiukai E,Shang Y,Zhang X,Liu S,Zhang X

Tue May 25 00:00:00 EDT 2021

Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries.

Cell death & disease

Zhou M,Liu X,Qiukai E,Shang Y,Zhang X,Liu S,Zhang X

Tue May 25 00:00:00 EDT 2021

Effect of Promoter Methylation on the Expression of Porcine MUC2 Gene and Resistance to PEDV Infection.

Frontiers in veterinary science

Xiao Y,Zhou Y,Sun S,Wang H,Wu S,Bao W

Tue May 18 00:00:00 EDT 2021

Asymmetrical arginine dimethylation of histone H4 by 8-oxog/OGG1/PRMT1 is essential for oxidative stress-induced transcription activation.

Free radical biology & medicine

Wang W,Ma Y,Huang M,Liang W,Zhao X,Li Q,Wang S,Hu Z,He L,Gao T,Chen J,Pan F,Guo Z

Sat Feb 20 00:00:00 EST 2021

Asymmetrical arginine dimethylation of histone H4 by 8-oxog/OGG1/PRMT1 is essential for oxidative stress-induced transcription activation.

Free radical biology & medicine

Wang W,Ma Y,Huang M,Liang W,Zhao X,Li Q,Wang S,Hu Z,He L,Gao T,Chen J,Pan F,Guo Z

Sat Feb 20 00:00:00 EST 2021

Asymmetrical arginine dimethylation of histone H4 by 8-oxog/OGG1/PRMT1 is essential for oxidative stress-induced transcription activation.

Free radical biology & medicine

Wang W,Ma Y,Huang M,Liang W,Zhao X,Li Q,Wang S,Hu Z,He L,Gao T,Chen J,Pan F,Guo Z

Sat Feb 20 00:00:00 EST 2021

YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.

International journal of biological sciences

Zhang T,Beeharry MK,Wang Z,Zhu Z,Li J,Li C

Wed Mar 30 00:00:00 EDT 2022

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP.

Arthritis research & therapy

Wang Y,Zhang K,Yuan X,Xu N,Zhao S,Hou L,Yang L,Zhang N

Tue Oct 06 00:00:00 EDT 2020

LncRNA NEAT1 Targets Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via the miR-410-3p/YY1 Axis.

Frontiers in immunology

Wang Y,Hou L,Yuan X,Xu N,Zhao S,Yang L,Zhang N

Fri Apr 30 00:00:00 EDT 2021

YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.

Biochemical and biophysical research communications

Shen X,Zhong J,Yu P,Zhao Q,Huang T

Tue Feb 05 00:00:00 EST 2019

YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.

Biochemical and biophysical research communications

Shen X,Zhong J,Yu P,Zhao Q,Huang T

Tue Feb 05 00:00:00 EST 2019

A haplotype variant of Hu sheep follicle-stimulating hormone receptor promoter region decreases transcriptional activity.

Animal genetics

Du X,Guo J,Cao QY,Yao W,Li QF

Thu Aug 01 00:00:00 EDT 2019

Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1.

Science translational medicine

Gao P,Li L,Yang L,Gui D,Zhang J,Han J,Wang J,Wang N,Lu J,Chen S,Hou L,Sun H,Xie L,Zhou J,Peng C,Lu Y,Peng X,Wang C,Miao J,Ozcan U,Huang Y,Jia W,Liu J

Wed Sep 18 00:00:00 EDT 2019

Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1.

Annals of translational medicine

Chen L,Guo T,Yu Y,Sun Y,Yu G,Cheng L

Tue Oct 01 00:00:00 EDT 2019

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

International journal of oncology

Huang Y,Tao T,Liu C,Guan H,Zhang G,Ling Z,Zhang L,Lu K,Chen S,Xu B,Chen M

Wed Feb 01 00:00:00 EST 2017

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

International journal of oncology

Huang Y,Tao T,Liu C,Guan H,Zhang G,Ling Z,Zhang L,Lu K,Chen S,Xu B,Chen M

Wed Feb 01 00:00:00 EST 2017

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

International journal of oncology

Huang Y,Tao T,Liu C,Guan H,Zhang G,Ling Z,Zhang L,Lu K,Chen S,Xu B,Chen M

Wed Feb 01 00:00:00 EST 2017

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

International journal of oncology

Huang Y,Tao T,Liu C,Guan H,Zhang G,Ling Z,Zhang L,Lu K,Chen S,Xu B,Chen M

Wed Feb 01 00:00:00 EST 2017

Changes in MicroRNA Expression During Maturation of the Bovine Corpus Luteum: Regulation of Luteal Cell Proliferation and Function by MicroRNA-34a.

Biology of reproduction

Maalouf SW,Smith CL,Pate JL

Tue Mar 01 00:00:00 EST 2016

Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

PloS one

Liu XC,Lian W,Zhang LJ,Feng XC,Gao Y,Li SX,Liu C,Cheng Y,Yang L,Wang XJ,Chen L,Wang RQ,Chai J,Chen WS

Mon May 16 00:00:00 EDT 2016

Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

PloS one

Liu XC,Lian W,Zhang LJ,Feng XC,Gao Y,Li SX,Liu C,Cheng Y,Yang L,Wang XJ,Chen L,Wang RQ,Chai J,Chen WS

Mon May 16 00:00:00 EDT 2016

Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

PloS one

Liu XC,Lian W,Zhang LJ,Feng XC,Gao Y,Li SX,Liu C,Cheng Y,Yang L,Wang XJ,Chen L,Wang RQ,Chai J,Chen WS

Mon May 16 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Delta transcription factor; INO80 complex subunit S; NF-E1; Transcriptional repressor protein YY1; UCR-motif DNA-binding protein; UCRBP transcription factor; Yin and yang 1; Yin and Yang 1 protein; Yin Yang 1; YY-1

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Gene Aliases: AW488674; DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1; YY1

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UniProt ID: (Human) P25490, (Mouse) Q00899

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Entrez Gene ID: (Human) 7528, (Mouse) 22632

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Function(s)

four-way junction DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity RNA binding protein binding zinc ion binding transcription regulatory region DNA binding SMAD binding nucleic acid binding histone deacetylase binding sequence-specific DNA binding metal ion binding C2H2 zinc finger transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter double-strand break repair via homologous recombination transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus spermatogenesis response to UV-C negative regulation of gene expression cell differentiation cellular response to UV DNA repair DNA recombination regulation of transcription, DNA-templated transcription from RNA polymerase II promoter RNA localization anterior/posterior pattern specification positive regulation of gene expression positive regulation of transcription from RNA polymerase II promoter camera-type eye morphogenesis chromosome organization cellular response to interleukin-1

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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YY1 Polyclonal Antibody

YY1 Antibody (22156-1-AP) in ICC/IF

Product Details

22156-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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