Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATGGGAEEE RKRGRPQLLP PARPAARGEE ADGGREKMGW AQVVKNLAEK KGEFREPRPP RREEESGGGG GSAGLGGPAG LAAPDLGDFP PAGRGDPKGR RRDPAGEAVD PRKKKGAAEA GRRKKAEAAA AAMATPARPG EAEDAAERPL QDEPAAAAGP GKGRFLVRIC FQGDEGACPT RDFVVGALIL RSIGMDPSDI YAVIQIPGSR EFDVSFRSAE KLALFLRVYE EKREQEDCWE NFVVLGRSKS SLKTLFILFR NETVDVEDIV TWLKRHCDVL AVPVKVTDRF GIWTGEYKCE IELRQGEGGV RHLPGAFFLG AERGYSWYKG QPKTCFKCGS RTHMSGSCTQ DRCFRCGEEG HLSPYCRKGI VCNLCGKRGH AFAQCPKAVH NSVAAQLTGV AGH
Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Zinc finger CCHC domain-containing protein 3; zinc finger, CCHC domain containing 3
Gene Aliases: C20orf99; ZCCHC3
UniProt ID: (Human) Q9NUD5
Entrez Gene ID: (Human) 85364
Molecular Function:
viral or transposable element protein
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