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Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). [UniProt]
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Protein Aliases: DHHC-6; H4 homolog; Palmitoyltransferase ZDHHC6; probable palmitoyltransferase ZDHHC6; Stearoyltransferase ZDHHC6; Transmembrane protein H4; Zinc finger DHHC domain-containing protein 6; Zinc finger protein 376; zinc finger, DHHC-type containing 6
Gene Aliases: 2400007G07Rik; 5930409M18Rik; AI462345; C77369; DHHC-6; ZDHHC6; ZNF376
UniProt ID: (Human) Q9H6R6, (Mouse) Q9CPV7
Entrez Gene ID: (Human) 64429, (Mouse) 66980
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