Proteintech

ZEB2 Polyclonal Antibody

ZEB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ZEB2 Antibody (14026-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 14026-1-AP ( ZEB2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

14026-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 50 publications 50 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZEB2 Fusion Protein Ag5171 (1-128 aa encoded by BC060819)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKQPIMADG PRCKRRKQAN PRRKNVVNYD NVVDTGSETD EEDKLHIAED DGIANPLDQE TSPASVPNHE SSPHVSQALL PREEEEDEIR EGGVEHPWHN NEILQASVDG PGKCLKSLDL FLYHLHIFN (1-128 aa encoded by BC060819 )

Target Information

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Microbiology and immunology

Li Y,Xiao W,Lin X

Wed Mar 01 00:00:00 EST 2023

LOXL1 and LOXL4 are novel target genes of the Zn²⁺-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.

Frontiers in oncology

Hirabayashi D,Yamamoto KI,Maruyama A,Tomonobu N,Kinoshita R,Chen Y,Komalasari NLGY,Murata H,Gohara Y,Jiang F,Zhou J,Ruma IMW,Sumardika IW,Yamauchi A,Kuribayashi F,Toyooka S,Inoue Y,Sakaguchi M

Tue Mar 14 00:00:00 EDT 2023

ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12.

International journal of cancer

Yun J,Kim YS,Heo MJ,Kim MJ,Moon A,Kim SG

Sun May 15 00:00:00 EDT 2022

Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial-mesenchymal transition.

Journal of translational medicine

Sun H,Zhang C,Zheng Y,Liu C,Wang X,Cong X

Fri Jul 22 00:00:00 EDT 2022

SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.

Cellular oncology (Dordrecht)

Cui X,Wang Y,Lan W,Wang S,Cui Y,Zhang X,Lin Z,Piao J

Tue Feb 01 00:00:00 EST 2022

Long non-coding RNA small nucleolar RNA host gene 1 alleviates the progression of recurrent spontaneous abortion via the microRNA-183-5p/ZEB2 axis.

Reproductive biology

Mo Y,Chen Z,Liu X,Gong F,Huang H,Hua R,Fang Y,Liang F

Tue Mar 01 00:00:00 EST 2022

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Cancers

Sun M,Zhang X,Bi F,Wang D,Zhou X,Li X,Yang Q

Tue Oct 25 00:00:00 EDT 2022

Regulation of Semaphorin3A in the process of cutaneous wound healing.

Cell death and differentiation

Zheng Y,Jiang F,Wang C,Dong M,Wang C,Yan E,Wang Y,Zhu Z,Xiong X,Ding X,Ye J,He Y,Zhang H,Zhou J,Zhang W,Wu Y,Song X

Sat Oct 01 00:00:00 EDT 2022

Regulation of Semaphorin3A in the process of cutaneous wound healing.

Cell death and differentiation

Zheng Y,Jiang F,Wang C,Dong M,Wang C,Yan E,Wang Y,Zhu Z,Xiong X,Ding X,Ye J,He Y,Zhang H,Zhou J,Zhang W,Wu Y,Song X

Sat Oct 01 00:00:00 EDT 2022

Autophagy deficiency promotes lung metastasis of prostate cancer via stabilization of TWIST1.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Shi YX,Sun ZW,Jia DL,Wang HB

Fri Jul 01 00:00:00 EDT 2022

Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.

Life sciences

Zhu M,Niu J,Jiang J,Dong T,Chen Y,Yang X,Liu P

Tue Mar 15 00:00:00 EDT 2022

LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression.

Journal of gastroenterology

Liu T,Liao S,Mo J,Bai X,Li Y,Zhang Y,Zhang D,Cheng R,Zhao N,Che N,Guo Y,Dong X,Zhao X

Sat Oct 01 00:00:00 EDT 2022

Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway.

Cell communication and signaling : CCS

Zhao Z,Chu W,Zheng Y,Wang C,Yang Y,Xu T,Yang X,Zhang W,Ding X,Li G,Zhang H,Zhou J,Ye J,Wu H,Song X,Wu Y

Sat Dec 18 00:00:00 EST 2021

CircRNA Lrp6 promotes cementoblast differentiation via miR-145a-5p/Zeb2 axis.

Journal of periodontal research

Li M,Du M,Wang Y,Zhu J,Pan J,Cao Z,He H

Wed Dec 01 00:00:00 EST 2021

CircRNA Lrp6 promotes cementoblast differentiation via miR-145a-5p/Zeb2 axis.

Journal of periodontal research

Li M,Du M,Wang Y,Zhu J,Pan J,Cao Z,He H

Wed Dec 01 00:00:00 EST 2021

TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1.

Frontiers in oncology

Li R,Zhu L,Peng Y,Zhang X,Dai C,Liu D

Wed Sep 29 00:00:00 EDT 2021

PFP@PLGA/Cu₁₂Sb₄S₁₃-mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT-CO1 signaling pathway.

Nano convergence

Dong T,Jiang J,Zhang H,Liu H,Zou X,Niu J,Mao Y,Zhu M,Chen X,Li Z,Chen Y,Shi C,Yang X

Mon Oct 04 00:00:00 EDT 2021

LINC01296/miR-141-3p/ZEB1-ZEB2 axis promotes tumor metastasis via enhancing epithelial-mesenchymal transition process.

Journal of Cancer

Sun Z,Shao B,Liu Z,Dang Q,Guo Y,Chen C,Guo Y,Chen Z,Liu J,Hu S,Yuan W,Zhou Q

Fri Apr 16 00:00:00 EDT 2021

Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.

Cancer science

Guo K,Wang P,Zhang L,Zhou Y,Dai X,Yan Y,Chen Y,Wasan HS,Yu J,Ruan S,Sun L

Fri Oct 01 00:00:00 EDT 2021

Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice.

Nature communications

Harn HI,Wang SP,Lai YC,Van Handel B,Liang YC,Tsai S,Schiessl IM,Sarkar A,Xi H,Hughes M,Kaemmer S,Tang MJ,Peti-Peterdi J,Pyle AD,Woolley TE,Evseenko D,Jiang TX,Chuong CM

Mon May 10 00:00:00 EDT 2021

Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.

PeerJ

Lee HY,Li CC,Li WM,Hsu YL,Yeh HC,Ke HL,Yeh BW,Huang CN,Li CF,Kuo PL,Wu WJ

Sat Apr 23 00:00:00 EDT 2022

Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.

PeerJ

Lee HY,Li CC,Li WM,Hsu YL,Yeh HC,Ke HL,Yeh BW,Huang CN,Li CF,Kuo PL,Wu WJ

Sat Apr 23 00:00:00 EDT 2022

Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.

BMC cancer

Liu C,Zhou X,Pan Y,Liu Y,Zhang Y

Tue Jun 22 00:00:00 EDT 2021

The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.

Chinese journal of natural medicines

Chen YD,Cai FY,Mao YZ,Yang YS,Xu K,Liu XF,Fan WW,Chen W,Jiang FQ,Zhang H

Mon Nov 01 00:00:00 EDT 2021

Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.

Oncology reports

Jiang F,Ren S,Chen Y,Zhang A,Zhu Y,Zhang Z,Li Z,Piao D

Fri Jan 01 00:00:00 EST 2021

CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis.

Reproductive biology and endocrinology : RB&E

Du Y,Liu X,Zhang S,Chen S,Guan X,Li Q,Chen X,Zhao Y

Tue Nov 30 00:00:00 EST 2021

Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.

Molecular therapy oncolytics

Hu Y,Yu J,Wang Q,Zhang L,Chen X,Cao Y,Zhao J,Xu Y,Jiang D,Wang Y,Xiong W

Fri Mar 27 00:00:00 EDT 2020

Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial-mesenchymal transition through the TGF-β/Smad pathway.

The Journal of international medical research

Liu J,Chen Y,Cao Z,Guan B,Peng J,Chen Y,Zhan Z,Sferra TJ,Sankararaman S,Lin J

Mon Jun 01 00:00:00 EDT 2020

Fangjihuangqi Decoction inhibits MDA-MB-231 cell invasion in vitro and decreases tumor growth and metastasis in triple-negative breast cancer xenografts tumor zebrafish model.

Cancer medicine

Guo Y,Fan Y,Pei X

Wed Apr 01 00:00:00 EDT 2020

Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis.

Molecular cancer research : MCR

Wang H,Wang C,Peng G,Yu D,Cui XG,Sun YH,Ma X

Sat Feb 01 00:00:00 EST 2020

CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling.

Journal of experimental & clinical cancer research : CR

Zhong Q,Fang Y,Lai Q,Wang S,He C,Li A,Liu S,Yan Q

Sat Jul 11 00:00:00 EDT 2020

Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression.

Journal of experimental & clinical cancer research : CR

Xu Y,Yu J,Huang Z,Fu B,Tao Y,Qi X,Mou Y,Hu Y,Wang Y,Cao Y,Jiang D,Xie J,Xu Y,Zhao J,Xiong W

Sun Apr 05 00:00:00 EDT 2020

Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway.

Cell death & disease

Li X,Ma N,Zhang Y,Wei H,Zhang H,Pang X,Li X,Wu D,Wang D,Yang Z,Zhang S

Tue May 26 00:00:00 EDT 2020

The Lnc LINC00461/miR-30a-5p facilitates progression and malignancy in non-small cell lung cancer via regulating ZEB2.

Cell cycle (Georgetown, Tex.)

Li X,Liu J,Liu M,Xia C,Zhao Q

Wed Apr 01 00:00:00 EDT 2020

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.

International journal of oncology

Jiang F,Chen Y,Ren S,Li Z,Sun K,Xing Y,Zhu Y,Piao D

Wed Jul 01 00:00:00 EDT 2020

Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.

Life sciences

Chen Y,Niu J,Li L,Li Z,Jiang J,Zhu M,Dong T,Zhang J,Shi C,Xu P,Lu Y,Jiang Y,Liu P,Chen W

Thu Oct 01 00:00:00 EDT 2020

Knockdown of Linc00511 inhibits TGF-β-induced cell migration and invasion by suppressing epithelial-mesenchymal transition and down-regulating MMPs expression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Jiang L,Xie X,Bi R,Ding F,Mei J

Fri May 01 00:00:00 EDT 2020

Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly.

iScience

Tsukamoto H,Kouwaki T,Oshiumi H

Fri Sep 25 00:00:00 EDT 2020

LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.

Cellular signalling

Ma T,Liang Y,Li Y,Song X,Zhang N,Li X,Chen B,Zhao W,Wang L,Yang Q

Wed Apr 01 00:00:00 EDT 2020

Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis by sponging miR-203a-3p in lung adenocarcinoma.

Journal of cellular physiology

Wang L,Zhang X,Liu Y,Xu S

Wed Apr 01 00:00:00 EDT 2020

KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2.

Cell adhesion & migration

Sun L,Zhou X,Li Y,Chen W,Wu S,Zhang B,Yao J,Xu A

Tue Dec 01 00:00:00 EST 2020

LncRNA SNHG5 Promotes Proliferation of Glioma by Regulating miR-205-5p/ZEB2 Axis.

OncoTargets and therapy

Meng X,Deng Y,Lv Z,Liu C,Guo Z,Li Y,Liu H,Xie B,Jin Z,Lin F,Zhu H

Tue Apr 12 00:00:00 EDT 2022

Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.

Journal of experimental & clinical cancer research : CR

Li Z,Chen Y,An T,Liu P,Zhu J,Yang H,Zhang W,Dong T,Jiang J,Zhang Y,Jiang M,Yang X

Fri Mar 29 00:00:00 EDT 2019

Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT.

Toxicology and applied pharmacology

Cao G,Li S,Shi H,Yin P,Chen J,Li H,Zhong Y,Diao LT,Du B

Sun Dec 15 00:00:00 EST 2019

Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis.

Cell cycle (Georgetown, Tex.)

Gao H,Li X,Zhan G,Zhu Y,Yu J,Wang J,Li L,Wu W,Liu N,Guo X

Sat Jun 01 00:00:00 EDT 2019

Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis.

Cell cycle (Georgetown, Tex.)

Gao H,Li X,Zhan G,Zhu Y,Yu J,Wang J,Li L,Wu W,Liu N,Guo X

Sat Jun 01 00:00:00 EDT 2019

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation.

Cancer cell international

Wang T,Lin F,Sun X,Jiang L,Mao R,Zhou S,Shang W,Bi R,Lu F,Li S

Thu Mar 31 00:00:00 EDT 2022

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation.

Cancer cell international

Wang T,Lin F,Sun X,Jiang L,Mao R,Zhou S,Shang W,Bi R,Lu F,Li S

Thu Mar 31 00:00:00 EDT 2022

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

Journal of cellular and molecular medicine

Wu W,He K,Guo Q,Chen J,Zhang M,Huang K,Yang D,Wu L,Deng Y,Luo X,Yu H,Ding Q,Xiang G

Wed May 01 00:00:00 EDT 2019

Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma.

Journal of cellular and molecular medicine

Diao P,Ge H,Song Y,Wu Y,Li J,Li Z,Yang J,Wang Y,Cheng J

Sat Jun 01 00:00:00 EDT 2019

Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma.

Molecular medicine reports

Li Q,Ma L,Wu Z,Wang G,Huang Q,Shen Z,Yu R

Sat Jun 01 00:00:00 EDT 2019

MicroRNA-507 represses the malignant behaviors of non-small cell lung cancer via targeting zinc finger E-box binding homeobox 2.

European review for medical and pharmacological sciences

Lv HL,Li ZL,Song YB

Fri Nov 01 00:00:00 EDT 2019

Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.

Theranostics

Chen Y,Liu P,Sun P,Jiang J,Zhu Y,Dong T,Cui Y,Tian Y,An T,Zhang J,Li Z,Yang X

Fri Jan 31 00:00:00 EST 2020

The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.

Molecular cancer therapeutics

Yin Y,Liu W,Shen Q,Zhang P,Wang L,Tao R,Li H,Ma X,Zeng X,Cheong JH,Song S,Ajani JA,Mills GB,Tao K,Peng G

Thu Aug 01 00:00:00 EDT 2019

The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.

Molecular cancer therapeutics

Yin Y,Liu W,Shen Q,Zhang P,Wang L,Tao R,Li H,Ma X,Zeng X,Cheong JH,Song S,Ajani JA,Mills GB,Tao K,Peng G

Thu Aug 01 00:00:00 EDT 2019

The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.

Molecular cancer therapeutics

Yin Y,Liu W,Shen Q,Zhang P,Wang L,Tao R,Li H,Ma X,Zeng X,Cheong JH,Song S,Ajani JA,Mills GB,Tao K,Peng G

Thu Aug 01 00:00:00 EDT 2019

The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.

Molecular cancer therapeutics

Yin Y,Liu W,Shen Q,Zhang P,Wang L,Tao R,Li H,Ma X,Zeng X,Cheong JH,Song S,Ajani JA,Mills GB,Tao K,Peng G

Thu Aug 01 00:00:00 EDT 2019

PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.

Cell death & disease

Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

Thu Feb 22 00:00:00 EST 2018

PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis.

Cell death & disease

Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

Thu Feb 22 00:00:00 EST 2018

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway.

Oncotarget

Wu X,Tao P,Zhou Q,Li J,Yu Z,Wang X,Li J,Li C,Yan M,Zhu Z,Liu B,Su L

Tue Mar 28 00:00:00 EDT 2017

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway.

Oncotarget

Wu X,Tao P,Zhou Q,Li J,Yu Z,Wang X,Li J,Li C,Yan M,Zhu Z,Liu B,Su L

Tue Mar 28 00:00:00 EDT 2017

miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition.

Journal of gastroenterology and hepatology

Yang J,Zhou CZ,Zhu R,Fan H,Liu XX,Duan XY,Tang Q,Shou ZX,Zuo DM

Fri Dec 01 00:00:00 EST 2017

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.

Oncotarget

Zhang S,Li J,Liu P,Xu J,Zhao W,Xie C,Yin Z,Wang X

Sun May 10 00:00:00 EDT 2015

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.

Oncotarget

Zhang S,Li J,Liu P,Xu J,Zhao W,Xie C,Yin Z,Wang X

Sun May 10 00:00:00 EDT 2015

High levels of secreted frizzled-related protein 1 correlate with poor prognosis and promote tumourigenesis in gastric cancer.

European journal of cancer (Oxford, England : 1990)

Qu Y,Ray PS,Li J,Cai Q,Bagaria SP,Moran C,Sim MS,Zhang J,Turner RR,Zhu Z,Cui X,Liu B

Fri Nov 01 00:00:00 EDT 2013

High levels of secreted frizzled-related protein 1 correlate with poor prognosis and promote tumourigenesis in gastric cancer.

European journal of cancer (Oxford, England : 1990)

Qu Y,Ray PS,Li J,Cai Q,Bagaria SP,Moran C,Sim MS,Zhang J,Turner RR,Zhu Z,Cui X,Liu B

Fri Nov 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b

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Gene Aliases: 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B; ZFX1B; Zfxh1b

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UniProt ID: (Human) A0JP09, (Mouse) Q9R0G7

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Entrez Gene ID: (Human) 9839, (Mouse) 24136, (Rat) 311071

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Function(s)

transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding phosphatase regulator activity metal ion binding R-SMAD binding nucleic acid binding molecular_function C2H2 zinc finger transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter neural crest cell migration somitogenesis neural tube closure transcription from RNA polymerase II promoter nervous system development corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of melanocyte differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of melanin biosynthetic process developmental pigmentation collateral sprouting positive regulation of axonogenesis mammillary axonal complex development melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization transcription, DNA-templated regulation of transcription, DNA-templated central nervous system development embryonic morphogenesis biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ZEB2 Polyclonal Antibody

ZEB2 Antibody (14026-1-AP) in IHC (P)

Product Details

14026-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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