Proteintech

ZFP36 Polyclonal Antibody

ZFP36 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

ZFP36 Antibody (12737-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 12737-1-AP (ZFP36 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

ZFP36 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

12737-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

RNA Immunoprecipitation (RIP)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ZFP36 Fusion Protein Ag3461 (1-326 aa encoded by BC009693)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDLTAIYES LLSLSPDVPV PSDHGGTESS PGWGSSGPWS LSPSDSSPSG VTSRLPGRST SLVEGRSCGW VPPPPGFAPL APRLGPELSP SPTSPTATST TPSRYKTELC RTFSESGRCR YGAKCQFAHG LGELRQANRH PKYKTELCHK FYLQGRCPYG SRCHFIHNPS EDLAAPGHPP VLRQSISFSG LPSGRRTSPP PPGLAGPSLS SSSFSPSSSP PPPGDLPLSP SAFSAAPGTP LARRDPTPVC CPSCRRATPI SVWGPLGGLV RTPSVQSLGS DPDEYASSGS SLGGSDSPVF EAGVFAPPQP VAAPRRLPIF NRISVSE (1-326 aa encoded by BC009693)

Target Information

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection.

bioRxiv : the preprint server for biology

Bennett AK,Richner M,Mun MD,Richner JM

Thu Jan 05 00:00:00 EST 2023

Targeting lncRNA DDIT4-AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Jiang T,Zhu J,Jiang S,Chen Z,Xu P,Gong R,Zhong C,Cheng Y,Sun X,Yi W,Yang J,Zhou W,Cheng Y

Thu Jun 01 00:00:00 EDT 2023

Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1.

American journal of physiology. Cell physiology

Zhao J,Yang S,Lv C,Liu Y

Mon May 01 00:00:00 EDT 2023

Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1.

American journal of physiology. Cell physiology

Zhao J,Yang S,Lv C,Liu Y

Mon May 01 00:00:00 EDT 2023

Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection.

Aging cell

Bennett AK,Richner M,Mun MD,Richner JM

Sat Apr 01 00:00:00 EDT 2023

Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.

Frontiers in microbiology

Wang Z,Yin L,Qi Y,Zhang J,Zhu H,Tang J

Fri Aug 05 00:00:00 EDT 2022

FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.

Pharmaceuticals (Basel, Switzerland)

Dang Y,He Q,Yang S,Sun H,Liu Y,Li W,Tang Y,Zheng Y,Wu T

Thu Sep 22 00:00:00 EDT 2022

Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.

Journal of translational medicine

Lyu F,Li Y,Yan Z,He Q,Cheng L,Zhang P,Liu B,Liu C,Song Y,Xing Y

Tue May 10 00:00:00 EDT 2022

Journal of translational medicine

Lyu F,Li Y,Yan Z,He Q,Cheng L,Zhang P,Liu B,Liu C,Song Y,Xing Y

Tue May 10 00:00:00 EDT 2022

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.

Cell reports

Dai XX,Jiang ZY,Wu YW,Sha QQ,Liu Y,Ding JY,Xi WD,Li J,Fan HY

Tue Nov 16 00:00:00 EST 2021

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.

Cell reports

Dai XX,Jiang ZY,Wu YW,Sha QQ,Liu Y,Ding JY,Xi WD,Li J,Fan HY

Tue Nov 16 00:00:00 EST 2021

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.

Cell reports

Dai XX,Jiang ZY,Wu YW,Sha QQ,Liu Y,Ding JY,Xi WD,Li J,Fan HY

Tue Nov 16 00:00:00 EST 2021

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.

Cell reports

Dai XX,Jiang ZY,Wu YW,Sha QQ,Liu Y,Ding JY,Xi WD,Li J,Fan HY

Tue Nov 16 00:00:00 EST 2021

Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.

Frontiers in genetics

Li XX,Xiong L,Wen Y,Zhang ZJ

Tue Dec 07 00:00:00 EST 2021

N⁶-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Developmental cell

Du J,Liao W,Liu W,Deb DK,He L,Hsu PJ,Nguyen T,Zhang L,Bissonnette M,He C,Li YC

Mon Dec 21 00:00:00 EST 2020

N⁶-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Developmental cell

Du J,Liao W,Liu W,Deb DK,He L,Hsu PJ,Nguyen T,Zhang L,Bissonnette M,He C,Li YC

Mon Dec 21 00:00:00 EST 2020

Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun X,Zhang H,Xie L,Qian C,Ye Y,Mao H,Wang B,Zhang H,Zhang Y,He X,Zhang S

Sun Nov 01 00:00:00 EDT 2020

Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun X,Zhang H,Xie L,Qian C,Ye Y,Mao H,Wang B,Zhang H,Zhang Y,He X,Zhang S

Sun Nov 01 00:00:00 EDT 2020

Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun X,Zhang H,Xie L,Qian C,Ye Y,Mao H,Wang B,Zhang H,Zhang Y,He X,Zhang S

Sun Nov 01 00:00:00 EDT 2020

Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun X,Zhang H,Xie L,Qian C,Ye Y,Mao H,Wang B,Zhang H,Zhang Y,He X,Zhang S

Sun Nov 01 00:00:00 EDT 2020

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change.

Molecular cell

Jalihal AP,Pitchiaya S,Xiao L,Bawa P,Jiang X,Bedi K,Parolia A,Cieslik M,Ljungman M,Chinnaiyan AM,Walter NG

Thu Sep 17 00:00:00 EDT 2020

Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.

Oncotarget

Li B,Li X,Xiong H,Zhou P,Ni Z,Yang T,Zhang Y,Zeng Y,He J,Yang F,Zhang N,Wang Y,Zheng Y,He F

Tue Aug 01 00:00:00 EDT 2017

Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.

Oncotarget

Li B,Li X,Xiong H,Zhou P,Ni Z,Yang T,Zhang Y,Zeng Y,He J,Yang F,Zhang N,Wang Y,Zheng Y,He F

Tue Aug 01 00:00:00 EDT 2017

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.

Scientific reports

Wang Y,Chen F,Yang Z,Zhao M,Zhang S,Gao Y,Feng J,Yang G,Zhang W,Ye L,Zhang X

Thu May 18 00:00:00 EDT 2017

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.

Scientific reports

Wang Y,Chen F,Yang Z,Zhao M,Zhang S,Gao Y,Feng J,Yang G,Zhang W,Ye L,Zhang X

Thu May 18 00:00:00 EDT 2017

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

Proceedings of the National Academy of Sciences of the United States of America

Tan FE,Elowitz MB

Tue Apr 29 00:00:00 EDT 2014

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

Proceedings of the National Academy of Sciences of the United States of America

Tan FE,Elowitz MB

Tue Apr 29 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; tristetraproline; TTP; Zfp-36; Zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog; zinc finger protein, C3H type, 36 homolog

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Gene Aliases: G0S24; GOS24; NUP475; RNF162A; TIS11; TIS11A; TIS11D; TISII; TTP; Zfp-36; ZFP36

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UniProt ID: (Human) P26651, (Mouse) P22893, (Rat) P47973

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Entrez Gene ID: (Human) 7538, (Mouse) 22695, (Rat) 79426

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Function(s)

DNA binding single-stranded RNA binding mRNA binding mRNA 3'-UTR binding protein binding AU-rich element binding enzyme binding protein kinase binding C-C chemokine binding mRNA 3'-UTR AU-rich region binding poly(A) RNA binding metal ion binding 14-3-3 protein binding RNA metabolism protein

Process(es)

negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening mRNA catabolic process response to wounding regulation of keratinocyte proliferation nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production miRNA mediated inhibition of translation p38MAPK cascade response to starvation regulation of mRNA stability cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of erythrocyte differentiation mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of keratinocyte apoptotic process positive regulation of intracellular mRNA localization regulation of transcription from RNA polymerase II promoter intracellular signal transduction negative regulation of myeloid cell differentiation negative regulation of inflammatory response RNA destabilization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ZFP36 Polyclonal Antibody

ZFP36 Antibody (12737-1-AP) in ICC/IF

Product Details

12737-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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