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Invitrogen
ZNF598 Recombinant Rabbit Monoclonal Antibody (5H5L17)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
ZNF598 Antibody (703601) in ICC/IF
For immunofluorescence analysis, HEK-293 cells were fixed and permeabilized for detection of endogenous ZNF598 using Anti-ZNF598 Recombinant Rabbit Monoclonal Antibody (Product # 703601, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of ZNF598 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (... View More
Product Details
703601
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
5H5L17
Immunogen
Protein corresponding to human ZNF598 [aa300-aa413]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2815335
Product Specific Information
This antibody is predicted to react with Mouse, Rat, Bovine.
Target Information
ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Zinc finger protein 598
Gene Aliases: ZNF598
UniProt ID: (Human) Q86UK7
Entrez Gene ID: (Human) 90850
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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