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ZNF638/NP220 Antibody (A301-548A-T) in WB
Detection of human ZNF638/NP220 by western blot. Samples: Whole cell lysate (50 µg) from 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-ZNF638/NP220 antibody A301-548A-M (lot A301-548A-M-2) used for WB at 1:1000. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A301-548A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 1928 and 1978
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTCL tumor antigen se33-1; CTCL-associated antigen se33-1; Cutaneous T-cell lymphoma-associated antigen se33-1; NP220 nuclear protein; Nuclear protein 220; Zinc finger matrin-like protein; Zinc finger protein 638; zinc finger, matrin-like
Gene Aliases: AI323587; mNP220; NP220; ZFML; Zfp638; ZNF638
UniProt ID: (Human) Q14966, (Mouse) Q61464
Entrez Gene ID: (Human) 27332, (Mouse) 18139
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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