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Product Details
PA5-37086
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 277-322 of human ZP4
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2553903
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 59 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The mammalian zona pellucida is composed of four major glycoproteins, ZP1, ZP2, ZP3 and ZP4, which may act as sperm receptors. Two forms of porcine ZP4 peptides exist: one consisting of 128 amino acid residues and the other of 133 amino acid residues. These two peptides are identical, except the larger form contains an additional five amino acid sequence at its carboxy-terminal end. Both peptides have two potential N-linked glycosylation sites. The smaller peptide shares 39.1% identity with the amino-terminal region of mouse ZP2 polypeptide. Based on results from animal studies, ZP4 antigen is a promising candidate for the development of a contraceptive vaccine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: zona pellucida 4; zona pellucida B glycoprotein; Zona pellucida glycoprotein 4; Zona pellucida protein B; Zona pellucida sperm-binding protein 4; Zp-4
Gene Aliases: ZBP; Zp-4; ZP1; ZP4; ZPB
UniProt ID: (Human) Q12836
Entrez Gene ID: (Human) 57829, (Rat) 282833
positive regulation of humoral immune response
single fertilization
protein kinase A signaling
intracellular signal transduction
positive regulation of T cell proliferation
positive regulation of protein kinase activity
acrosomal vesicle exocytosis
protein kinase C signaling
positive regulation of acrosome reaction
negative regulation of binding of sperm to zona pellucida
binding of sperm to zona pellucida
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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