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Product Details
PA5-20901
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human ZSCAN4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152831
Product Specific Information
A suggested positive control is mouse lung tissue lysate.
PA5-20901 can be used with blocking peptide PEP-1015.
Target Information
Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: zinc finger and SCAN domain containing 4F; Zinc finger and SCAN domain containing protein 4F; Zinc finger and SCAN domain-containing protein 4; Zinc finger protein 494
Gene Aliases: C330039H09Rik; RGD1563625; ZNF494; ZSCAN4; Zscan4f
UniProt ID: (Human) Q8NAM6, (Mouse) Q3URS2
Entrez Gene ID: (Human) 201516, (Rat) 503124, (Mouse) 665902
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
nucleic acid binding
DNA binding
C2H2 zinc finger transcription factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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