Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Specficity: The antibody detects endogenous levels of total ZUFSP protein.
Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DUB; Lys-63-specific deubiquitinase ZUFSP; Zinc finger with UFM1-specific peptidase domain protein; Zinc finger-containing ubiquitin peptidase 1
Gene Aliases: C6orf113; dJ412I7.3; ZUFSP; ZUP1
UniProt ID: (Human) Q96AP4
Entrez Gene ID: (Human) 221302
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