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Product Details
14281-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZWILCH Fusion Protein Ag5454 (179-477 aa encoded by BC036900)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KSAVELVQE FLNDLNKLDG FGDSTKKDTE VETLKHDTAA VDRSVKRLFK VRSDLDFAEQ LWCKMSSSVI SYQDLVKCFT LIIQSLQRGD IQPWLHSGSN SLLSKLIHQS YHGTMDTVSL SGTIPVQMLL EIGLDKLKKD YISFFIGQEL ASLNHLEYFI APSVDIQEQV YRVQKLHHIL EILVSCMPFI KSQHELLFSL TQICIKYYKQ NPLDEQHIFQ LPVRPTAVKN LYQSEKPQKW RVEIYSGQKK IKTVWQLSDS SPIDHLNFHK PDFSELTLNG SLEERIFFTN MVTCSQVHFK (179-477 aa encoded by BC036900)
Target Information
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homolog of Drosophila Zwilch; hZwilch; Protein zwilch homolog; zwilch kinetochore protein; Zwilch, kinetochore associated, homolog
Gene Aliases: 2310031L18Rik; hZwilch; KNTC1AP; ZWILCH
UniProt ID: (Human) Q9H900, (Mouse) Q8R060
Entrez Gene ID: (Human) 55055, (Mouse) 68014, (Rat) 691493
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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