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Product Details
H00055055-M11
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1C10
Immunogen
ZWILCH (AAH36900, 1 a.a. approximately 477 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MAHNPNMTHL KINLPVTALP PLWVRCDSSD PEGTCWLGAE LITTNNSITG IVLYVVSCKA DKNYSVNLEN LKNLHKKRHH LSTVTSKGFA QYELFKSSAL DDTITASQTA IALDISWSPV DEILQIPPLS STATLNIKVE SGEPRGPLNH LYRELKFLLV LADGLRTGVT EWLEPLEAKS AVELVQEFLN DLNKLDGFGD STKKDTEVET LKHDTAAVDR SVKRLFKVRS DLDFAEQLWC KMSSSVISYQ DLVKCFTLII QSLQRGDIQP WLHSGSNSLL SKLIHQSYHG TMDTVSLSGT IPVQMLLEIG LDKLKKDYIS FFIGQELASL NHLEYFIAPS VDIQEQVYRV QKLHHILEIL VSCMPFIKSQ HELLFSLTQI CIKYYKQNPL DEQHIFQLPV RPTAVKNLYQ SEKPQKWRVE IYSGQKKIKT VWQLSDSSPI DHLNFHKPDF SELTLNGSLE ERIFFTNMVT CSQVHFK
Target Information
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of Drosophila Zwilch; hZwilch; Protein zwilch homolog; Zwilch, kinetochore associated, homolog
Gene Aliases: hZwilch; KNTC1AP; ZWILCH
UniProt ID: (Human) Q9H900
Entrez Gene ID: (Human) 55055
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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