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Invitrogen
Zika Virus NS5 (strain H/PF/2013) Polyclonal Antibody
Product Details
PA5-143441
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of Zika virus NS5 protein (Zika virus (strain H/PF/2013)). The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.86 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2938436
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Positive control: Zika-infected Vero.
Target Information
Zika Virus nonstructural protein 5 (NS5) interacts with the host retinoic acid-inducible gene I (RIG-I), which is an essential signaling molecule for defending pathogen infections. NS5 subsequently represses K63-linked polyubiquitination of RIG-I, attenuates the phosphorylation and nuclear translocation of interferon regulatory factor 3 (IRF3), and inhibits the expression and production of interferon-beta (IFN-beta), thus restricting the RIG-I signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NS5; NS5 protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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