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Product Details
MA5-42774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4F9P3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Zyxin (Q15942).
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911915
Product Specific Information
Positive test controls include: MCF7, Mouse lung. The target is usually found in the following locations: Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion.
Immunogen sequence: TQPRGPPASS PAPAPKFSPV TPKFTPVASK FSPGAPGGSG SQPNQKLGHP EALSAGTGSP QPPSFTYAQQ REKPRVQEKQ HPVPPPAQNQ NQVRSPGAPG P
Target Information
Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zyxin; Zyxin-2
Gene Aliases: 9530098H06Rik; ESP-2; HED-2; R75157; ZYX
UniProt ID: (Human) Q15942, (Mouse) Q62523
Entrez Gene ID: (Human) 7791, (Mouse) 22793
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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