Alomone Labs, LTD

alpha 2A-Adrenergic Receptor (extracellular) Polyclonal Antibody

View all (11) alpha-2a Adrenergic Receptor antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AAR-020-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:250
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha 2A-adrenoceptor, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10

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Gene Aliases: Adra-2; Adra-2a; Adra2a; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; AW122659; CA2-47; RATRG20; RG20

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UniProt ID: (Mouse) Q01338, (Rat) P22909

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Entrez Gene ID: (Mouse) 11551, (Rat) 25083

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Function(s)
adrenergic receptor activity alpha2-adrenergic receptor activity protein kinase binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding G-protein coupled receptor
Process(es)
positive regulation of cytokine production acute inflammatory response DNA replication G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity cell-cell signaling female pregnancy negative regulation of norepinephrine secretion positive regulation of cell migration negative regulation of cAMP biosynthetic process activation of protein kinase activity activation of protein kinase B activity cellular response to hormone stimulus epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway glucose homeostasis fear response positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of vasodilation negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway activation of MAPK activity by adrenergic receptor signaling pathway positive regulation of wound healing regulation of smooth muscle contraction signal transduction regulation of vasoconstriction platelet activation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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