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Invitrogen
alpha Actinin 2 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
alpha Actinin 2 Antibody (PA5-82346)
Relative expression in different tissues in IHC: Detection of differential expression levels of alpha Actinin 2 demonstrates antibody specificity. Immunohistochemical analysis of alpha Actinin 2 using anti-alpha Actinin 2 Polyclonal Antibody (Product #PA5-82346), shows significant staining of alpha Actinin 2 in skeletal muscle and shows minimal or weak staining in prostate tissues. The relative expression ... View More
Product Details
PA5-82346
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ACTN2. Recombinant protein control fragment (Product #RP-102321).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789505
Product Specific Information
Immunogen sequence: AHEQFKATLP EADGERQSIM AIQNEVEKVI QSYNIRISSS NPYSTVTMDE LRTKWDKVKQ LVPIRDQSLQ EELARQHANE RLRRQFAAQA NAIGPWIQNK MEEIARSSIQ ITGALEDQMN QLKQYEHNII NYKNNIDKLE GD
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actinin, alpha 2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; F-actin cross-linking protein
Gene Aliases: ACTN2; CMD1AA; CMH23
UniProt ID: (Human) P35609
Entrez Gene ID: (Human) 88
Ras guanyl-nucleotide exchange factor activity
integrin binding
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
cytoskeletal protein binding
structural constituent of muscle
protein domain specific binding
LIM domain binding
thyroid hormone receptor coactivator activity
titin binding
identical protein binding
protein homodimerization activity
ion channel binding
protein dimerization activity
actin filament binding
FATZ binding
titin Z domain binding
MAPK cascade
platelet degranulation
cell adhesion
microspike assembly
muscle filament sliding
regulation of membrane potential
regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of potassium ion transport
positive regulation of GTPase activity
sarcomere organization
focal adhesion assembly
protein homotetramerization
actin filament uncapping
cardiac muscle cell development
phospholipase C-activating angiotensin-activated signaling pathway
establishment of protein localization to plasma membrane
negative regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transmembrane transporter activity
regulation of nucleic acid-templated transcription
negative regulation of protein localization to cell surface
positive regulation of receptor activity
positive regulation of endocytic recycling
positive regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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